Biodegradable iron-containing compositions, methods of preparing and applications therefor

Patent metadata

Field	Value
Publication number	US-2020000973-A1
Application number	US-201916559810-A
Country	US
Kind code	A1
Filing date	Sep 4, 2019
Priority date	Oct 5, 2012
Publication date	Jan 2, 2020
Grant date	—

Abstract

The invention relates to biodegradable iron alloy-containing compositions for use in preparing medical devices. In addition, biodegradable crystalline and amorphous compositions of the invention exhibit properties that make them suitable for use as medical devices for implantation into a body of a patient. The compositions include elemental iron and one or more elements selected from manganese, magnesium, zirconium, zinc and calcium. The compositions can be prepared using a high energy milling technique. The resulting compositions and the devices formed therefrom are useful in various surgical procedures, such as but not limited to orthopedic, craniofacial and cardiovascular.

First claim

1 . A biodegradable iron-based alloy, comprising:
(a) magnesium, manganese and calcium, or (b) magnesium, zirconium and calcium; and a remainder of iron.

2 . The alloy of claim 1 , wherein the magnesium, manganese and calcium in (a) are each present in an amount such that the magnesium constitutes from greater than zero weight percent to about 10.0 weight percent, the manganese constitutes from about 5.0 weight percent to about 75.0 weight percent, and the calcium constitutes from greater than zero weight percent to about 10.0 weight percent, based on total weight of the composition.

3 . The alloy of claim 1 , wherein the magnesium, zirconium and calcium in (b) are each present in an amount such that the magnesium constitutes from greater than zero weight percent to about 7.0 weight percent, the zirconium constitutes from about 8.0 weight percent to about 52.0 weight percent, and the calcium constitutes from greater than zero weight percent to about 30.0 weight percent, based on total weight of the composition.

4 . A method of preparing a biodegradable iron-based alloy, comprising:
charging in a high energy mill (a) magnesium, manganese, calcium and a remainder of iron, or (b) magnesium, zirconium, calcium and a remainder of iron; and conducting high energy milling of the magnesium, manganese, calcium and a remainder of iron in (a), or the magnesium, zirconium, calcium and a remainder of iron in (b).

5 . The method of claim 4 , wherein the high energy milling is conducted in dry conditions followed by high energy milling conducted in wet conditions.

6 . The method of claim 4 , wherein material resulting from the high energy milling is subjected to a casting process to form an iron-based alloy cast.

7 . A biodegradable medical device comprising the iron-based alloy of claim 1 .

8 . The device of claim 7 , wherein said device is selected from the group consisting of plate, mesh, staple, screw, pin, tack, rod, suture anchor, tubular mesh, coil, x-ray marker, catheter, pipe, shield, bolt, clip, plug, dental implant, graft device, endoprosthesis, bone-fracture healing device, bone replacement device, joint replacement device, tissue regeneration device, cardiovascular stent, nerve guide, surgical implant, surgical wire and combinations thereof.

9 . The device of claim 7 , wherein said device is an implantable device.

10 . The device of claim 9 , wherein the implantable device is selected from the group consisting of an orthopedic device, a craniofacial device and a cardiovascular device.

Assignees

• Univ Pittsburgh Commonwealth Sys Higher Education

Inventors

• Kumta Prashant N
• Chung Sung Jae
• Saha Partha
• Velikokhatnyi Oleg
• Datta Moni Kanchan
• Hong Dae Ho
• Chou Da-Tren

Classifications

• A61L31/022 Primary

  Metals or alloys · CPC title

• A61L31/148

  Materials at least partially resorbable by the body · CPC title

• C22C38/002

  containing In, Mg, or other elements not provided for in one single group C22C38/001 - C22C38/60 · CPC title

• C22C38/00

  Ferrous alloys, e.g. steel alloys (cast-iron alloys C22C37/00) · CPC title

• C22C45/02

  with iron as the major constituent · CPC title