Iron oxide/nanokaolin composite hemostatic agent and preparation method thereof

Patent metadata

Field	Value
Publication number	US-2019365801-A1
Application number	US-201816477176-A
Country	US
Kind code	A1
Filing date	Apr 26, 2018
Priority date	Jun 9, 2017
Publication date	Dec 5, 2019
Grant date	—

Abstract

The present invention discloses an iron oxide/nanokaolin composite hemostatic agent and a preparation method thereof. The composite hemostatic agent is composed of nanokaolin and iron oxide, where the nanokaolin is used as a carrier, and the iron oxide is loaded on a surface of a nanokaolin flake. The composite hemostatic agent is obtained by a precipitation method. The composite hemostatic agent has the advantages of good hemostatic effect, rapid wound healing, no obvious cytotoxicity, no hemolysis, high biocompatibility, and the like.

First claim

1 . An iron oxide/nanokaolin composite hemostatic agent, comprising an active ingredient of the composite hemostatic agent is a composite of a nanokaolin and an iron oxide.

2 . The iron oxide/nanokaolin composite hemostatic agent according to claim 1 , wherein the active ingredient is made by loading the iron oxide on a surface of the nanokaolin.

3 . The iron oxide/nanokaolin composite hemostatic agent according to claim 2 , wherein a mass percentage of the iron oxide is 15%-45%.

4 . The iron oxide/nanokaolin composite hemostatic agent according to claim 1 , wherein the iron oxide is iron oxyhydroxide, α-ferric oxide, γ-ferric oxide and/or ferroferric oxide.

5 . An iron oxide/nanokaolin composite hemostatic agent, comprising a composite of a nanokaolin and an iron oxide.

6 . The iron oxide/nanokaolin composite hemostatic agent according to claim 5 , wherein the iron oxide is loaded on a surface of the nanokaolin.

7 . The iron oxide/nanokaolin composite hemostatic agent according to claim 6 , wherein a mass percentage of the iron oxide is 15%-45%.

8 . The iron oxide/nanokaolin composite hemostatic agent according to claim 5 , wherein the iron oxide is iron oxyhydroxide, α-ferric oxide, γ-ferric oxide and/or ferroferric oxide.

9 . A preparation method of the iron oxide/nanokaolin composite hemostatic agent according to claim 1 , comprising:
a preparation of an iron oxyhydroxide/nanokaolin composite hemostatic agent comprises following steps of: A, mixing nanokaolin with a polymerized hydroxy iron ion solution, and reacting under a system pH value of 3-7 and a temperature of 50° C. to 70° C. to obtain the iron oxyhydroxide/nanokaolin composite hemostatic agent; or a preparation of an α-ferric oxide/nanokaolin composite hemostatic agent comprises following steps of: preparing the iron oxyhydroxide/nanokaolin composite hemostatic agent according to the step A; B, placing the iron oxyhydroxide/nanokaolin composite hemostatic agent in an air atmosphere, and calcining at a temperature of 500° C. to 550° C., to obtain the α-ferric oxide/nanokaolin composite hemostatic agent; or a preparation of a ferroferric oxide/nanokaolin composite hemostatic agent comprises following steps of: preparing the α-ferric oxide/nanokaolin composite hemostatic agent according to the steps A and B; C, placing the α-ferric oxide/nanokaolin composite hemostatic agent under a reducing atmosphere, and a calcination is carried out at a temperature of 400° C. to 450° C. to obtain the ferroferric oxide/nanokaolin composite hemostatic agent; or a preparation of a γ-ferric oxide/nanokaolin composite hemostatic agent comprises following steps of: preparing the ferroferric oxide/nanokaolin composite hemostatic agent according to the steps A, B and C; and D, placing the ferroferric oxide/nanokaolin composite hemostatic agent in an air atmosphere and calcining at a temperature of 200° C. to 250° C. to obtain the γ-ferric oxide/nanokaolin composite hemostatic agent.

10 . The preparation method of the iron oxide/nanokaolin composite hemostatic agent according to claim 9 , wherein the nanokaolin is obtained by intercalating and stripping a kaolin.

11 . The preparation method of the iron oxide/nanokaolin composite hemostatic agent according to claim 9 , wherein the polymerized hydroxy iron ion solution is prepared by following method of: adding a sodium hydroxide solution to a ferric chloride solution dropwise under a condition of 40° C. to 80° C., and then aging at room temperature for 12 h to 24 h to obtain the polymerized hydroxy iron ion solution.

12 . The preparation method of the iron oxide/nanokaolin composite hemostatic agent according to claim 9 , wherein a solid-liquid ratio of the nanokaolin to the polymerized hydroxy iron ion solution is (1-3)/50 g/mL, and a concentration of the polymerized hydroxy iron ion solution is 0.1-0.6 mol/L.

13 . The preparation method of the iron oxide/nanokaolin composite hemostatic agent according to claim 9 , wherein in the step A, a reaction time is 24-72 h.

14 . The preparation method of the iron oxide/nanokaolin composite hemostatic agent according to claim 9 , wherein in the step C, the calcination is performed in a hydrogen/argon mixed atmosphere with a hydrogen concentration of 5-12% by volume.

15 . A preparation method of the iron oxide/nanokaolin composite hemostatic agent according to claim 5 , comprising:
a preparation of an iron oxyhydroxide/nanokaolin composite hemostatic agent comprises following steps of: A, mixing nanokaolin with a polymerized hydroxy iron ion solution, and reacting under a system pH value of 3-7 and a temperature of 50° C. to 70° C. to obtain the iron oxyhydroxide/nanokaolin composite hemostatic agent; or a preparation of an α-ferric oxide/nanokaolin composite hemostatic agent comprises following steps of: preparing the iron oxyhydroxide/nanokaolin composite hemostatic agent according to the step A; B, placing the iron oxyhydroxide/nanokaolin composite hemostatic agent in an air atmosphere, and calcining at a temperature of 500° C. to 550° C., to obtain the α-ferric oxide/nanokaolin composite hemostatic agent; or a preparation of a ferroferric oxide/nanokaolin composite hemostatic agent comprises following steps of: preparing the α-ferric oxide/nanokaolin composite hemostatic agent according to the steps A and B; C, placing the α-ferric oxide/nanokaolin composite hemostatic agent under a reducing atmosphere, and a calcination is carried out at a temperature of 400° C. to 450° C. to obtain the ferroferric oxide/nanokaolin composite hemostatic agent; or a preparation of a γ-ferric oxide/nanokaolin composite hemostatic agent comprises following steps of: preparing the ferroferric oxide/nanokaolin composite hemostatic agent according to the steps A, B and C; and D, placing the ferroferric oxide/nanokaolin composite hemostatic agent in an air atmosphere and calcining at a temperature of 200° C. to 250° C. to obtain the γ-ferric oxide/nanokaolin composite hemostatic agent.

16 . The preparation method of the iron oxide/nanokaolin composite hemostatic agent according to claim 15 , wherein the nanokaolin is obtained by intercalating and stripping a kaolin.

17 . The preparation method of the iron oxide/nanokaolin composite hemostatic agent according to claim 15 , wherein the polymerized hydroxy iron ion solution is prepared by following method of: adding a sodium hydroxide solution to a ferric chloride solution dropwise under a condition of 40° C. to 80° C., and then aging at room temperature for 12 h to 24 h to obtain the polymerized hydroxy iron ion solution.

18 . The preparation method of the iron oxide/nanokaolin composite hemostatic agent according to claim 15 , wherein a solid-liquid ratio of the nanokaolin to the polymerized hydroxy iron ion solution is (1-3)/50 g/mL, and a concentration of the polymerized hydroxy iron ion solution is 0.1-0.6 mol/L.

19 . The preparation method of the iron oxide/nanokaolin composite hemostatic agent according to claim 15 , wherein in the step A, a reaction time is 24-72 h.

20 . The preparation method of the iron oxide/nanokaolin composite hemostatic agent according to claim 15 , wherein in the step C, the calcination is performed in a hydrogen/argon mixed atmosphere with a hydrogen concentration of 5-12% by volume.

Assignees

• Univ Central South

Inventors

• Yang Huaming
• Zhang Yi
• Long Mei

Classifications

• A61K35/02

  from inanimate materials (carbon A61K33/44) · CPC title

• A61K33/26 Primary

  Iron; Compounds thereof · CPC title

• A61P7/04

  Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents · CPC title

• A61L2400/12

  Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces · CPC title

• A61L2400/04

  Materials for stopping bleeding · CPC title