Chemical method for preparing heme iron not derived from porcine blood

Patent metadata

Field	Value
Publication number	US-2019345182-A1
Application number	US-201716475410-A
Country	US
Kind code	A1
Filing date	Dec 6, 2017
Priority date	Jan 3, 2017
Publication date	Nov 14, 2019
Grant date	—

Abstract

The present invention relates to heme iron not derived from porcine blood and a method of preparing the same, and more particularly to a method of chemically preparing heme iron not derived from porcine blood, a method of preparing a salt thereof, and an iron supplement containing the salt thus prepared as an active ingredient.

First claim

1 . A method of chemically preparing a salt of heme iron of Chemical Formula 1 below, not derived from porcine blood, containing no animal component, and having high purity, the method comprising:
A) dissolving a protoporphyrin IX derivative in an organic solvent, adding an iron compound and performing heating; B) removing the organic solvent; and C) subjecting a product obtained in step B) to chlorination.

2 . The method of claim 1 , further comprising purification process between step B) and step C).

3 . The method of claim 1 , further comprising dewatering process after step C).

4 . The method of claim 1 , wherein the protoporphyrin IX derivative is protoporphyrin IX or protoporphyrin IX dimethyl ester.

5 . The method of claim 1 , wherein the organic solvent is tetrahydrofuran or N,N-dimethylformamide.

6 . The method of claim 1 , wherein the iron compound is selected from the group consisting of FeCl 2 .4H 2 O, FeBr 2 .4H 2 O, and FeI 2 .4H 2 O.

7 . The method of claim 2 , wherein the purification is performed using diatomaceous earth.

8 . The method of claim 1 , wherein the high purity is 95% or more.

9 . A salt of heme iron of Chemical Formula 1 below not derived from porcine blood and containing no animal component, prepared by the method of claim 1 .

10 . A pharmaceutical composition for preventing or treating iron-deficiency anemia, containing the salt of heme iron of claim 9 as an active ingredient, without containing an animal component.

Assignees

• Intron Biotechnology Inc

Inventors

• Yoon Seong Jun
• Pyo Jung In
• Hwang Soon Hye
• Jun Soo Youn
• Kang Sang Hyeon

Classifications

• A61K31/555 Primary

  containing heavy metals, e.g. hemin, hematin, melarsoprol · CPC title

• C07F15/025 Primary

  without a metal-carbon linkage · CPC title

• A61K31/409

  having four such rings, e.g. porphine derivatives, bilirubin, biliverdine (hemin, hematin A61K31/555) · CPC title

• C07D487/22

  in which the condensed system contains four or more hetero rings · CPC title