Composition for external use

Patent metadata

Field	Value
Publication number	US-2019343796-A1
Application number	US-201716474405-A
Country	US
Kind code	A1
Filing date	Dec 28, 2017
Priority date	Dec 28, 2016
Publication date	Nov 14, 2019
Grant date	—

Abstract

An object of the present invention is to provide a composition for external use having an improved skin permeability of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof. The present invention provides a composition for external use comprising 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof, one or more solvents selected from the group consisting of alcohols, sulfoxides and amides, and a permeation enhancer.

First claim

1 - 13 . (canceled)

14 . A composition for external use comprising 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof, one or more solvents selected from the group consisting of alcohols, sulfoxides and amides, and a permeation enhancer.

15 . The composition for external use according to claim 14 , wherein the solvent is selected from the group consisting of ethanol, benzyl alcohol, propylene glycol, butylene glycol, dipropylene glycol, polyethylene glycol, dimethyl sulfoxide and N-methyl-2-pyrrolidone.

16 . The composition for external use according to claim 14 , further comprising water.

17 . The composition for external use according to claim 14 , wherein the permeation enhancer is a compound having a carboxyl group, a hydroxyl group or an alkoxycarbonyl group.

18 . The composition for external use according to claim 14 , wherein the permeation enhancer is a compound having an aliphatic group having 5 to 18 carbon atoms.

19 . The composition for external use according to claim 14 , further comprising a water-soluble polymer.

20 . The composition for external use according to claim 19 , wherein the water-soluble polymer is selected from the group consisting of carrageenan, propylene glycol alginate, agar, gelatin, hydroxypropyl cellulose, polyvinyl pyrrolidone, carboxyvinyl polymer, sodium polyacrylate and polyvinyl alcohol.

21 . The composition for external use according to claim 19 , wherein the water-soluble polymer is selected from the group consisting of propylene glycol alginate, agar, gelatin, hydroxypropyl cellulose and polyvinyl pyrrolidone.

22 . The composition for external use according to claim 14 , further comprising an adhesive agent.

23 . The composition for external use according to claim 14 , wherein the composition is a transdermal composition for external use.

24 . An adhesive preparation comprising the composition for external use according to claim 14 .

25 . The adhesive preparation according to claim 24 , wherein the adhesive preparation is a cataplasm or a patch.

26 . The composition for external use according to claim 14 , wherein the composition is a transnasal composition for external use.

Assignees

• Fujifilm Toyama Chemical Co Ltd

Inventors

• Yamazaki Naomi
• Noro Masaki
• Tsujihata Shigetomo

Classifications

• A61K9/06

  Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)} · CPC title

• A61K47/42

  Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein (oligopeptides having up to five amino acids {A61K47/183}; polyamino acids A61K47/34) · CPC title

• A61K31/397 Primary

  having four-membered rings, e.g. azetidine · CPC title

• A61K9/0014

  Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00) · CPC title

• A61K47/32

  Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone} · CPC title