Novel vibrio parahaemolyticus bacteriophage vib-pap-4 and use thereof in inhibiting proliferation of vibrio parahaemoliticus bacteria

Patent metadata

Field	Value
Publication number	US-2019328803-A1
Application number	US-201716471051-A
Country	US
Kind code	A1
Filing date	Nov 29, 2017
Priority date	Dec 21, 2016
Publication date	Oct 31, 2019
Grant date	—

Abstract

The present invention relates to Myoviridae bacteriophage Vib-PAP-4 (Accession No. KCTC 13168BP), isolated from nature, which possesses ability to specifically kill Vibrio parahaemolyticus bacteria and has the genome represented by SEQ ID No: 1, and a method for preventing infection of Vibrio parahaemolyticus bacteria and treating infection of Vibrio parahaemolyticus baceteria, using a composition containing the bacteriophage as an effective ingredient.

First claim

1 . A Myoviridae bacteriophage Vib-PAP-4 (Accession number: KCTC 13168BP) isolated from nature, which has an ability to specifically kill Vibrio parahaemolyticus and which includes a genome expressed by SEQ. ID. NO: 1.

2 . A composition for preventing or treating an infection of vibriosis caused by Vibrio parahaemolyticus, comprising:
said bacteriophage Vib-PAP-4 (Accession number: KCTC 13168BP) of claim 1 as an active ingredient.

3 . The composition for preventing or treating an infection of vibriosis caused by Vibrio parahaemolyticus of claim 2 , wherein said composition is used in a form of a medicine bath agent or a feed additive.

4 . A method for preventing or treating vibriosis caused by Vibrio parahaemolyticus, the method comprising:
immersing an animal other than a human in the composition including the bacteriophage Vib-PAP-4 (Accession number: KCTC 13168BP) of claim 2 as an active ingredient.

5 . The method for preventing or treating vibriosis caused by Vibrio parahaemolyticus of claim 4 , wherein said composition is in a form of a medicine bath agent.

6 . A method for preventing or treating vibriosis caused by Vibrio parahaemolyticus, the method comprising:
administering to an animal other than a human the composition including the bacteriophage Vib-PAP-4 (Accession number: KCTC 13168BP) of claim 2 as an active ingredient.

7 . The method for preventing or treating vibriosis caused by Vibrio parahaemolyticus of claim 6 , wherein said composition is in a form of a feed additive.

Assignees

• Intron Biotechnology Inc

Inventors

• Yoon Seong Jun
• Jun Soo Youn
• Kwon An Sung
• Song Hyun Min
• Hwang Soon Hye
• Kang Sang Hyeon

Classifications

• A23K20/163

  Sugars; Polysaccharides · CPC title

• A23K50/80

  for aquatic animals, e.g. fish, crustaceans or molluscs · CPC title

• C12N2795/10133

  Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory · CPC title

• C12N2795/10121

  Viruses as such, e.g. new isolates, mutants or their genomic sequences · CPC title

• A61K35/76 Primary

  Viruses; Subviral particles; Bacteriophages · CPC title