Composition for inhibiting survival or growth of tubercle bacillus by adjusting polarization of macrophage, and method using same

Patent metadata

Field	Value
Publication number	US-2019307850-A1
Application number	US-201716315607-A
Country	US
Kind code	A1
Filing date	Jul 4, 2017
Priority date	Jul 5, 2016
Publication date	Oct 10, 2019
Grant date	—

Abstract

The present invention provides a composition for inhibiting the survival or growth of a tubercle bacillus, containing a material which induces the polarization of a macrophage into an M1 macrophage, and a method for inhibiting the survival or growth of the tubercle bacillus by using the composition.

First claim

1 . A composition for inhibiting the survival or proliferation of Mycobacterium tuberculosis , comprising a material inducing the polarization of macrophages into M1 macrophages.

2 . The composition of claim 1 , wherein the material inducing polarization comprises at least one selected from the group consisting of lipopolysaccharide, interferon-gamma, IL-6 and TNF-α.

3 . The composition of claim 2 , comprising 1-20 ng/ml of lipopolysaccharide and 1-20 ng/ml of interferon-gamma.

4 . The composition of claim 1 , further comprising at least one anti-tuberculosis drug selected from the group consisting of rifampicin, isoniazid, ethambutol, pyrazinamide or analogues thereof.

5 . The composition of claim 1 , wherein the tuberculosis is eye tuberculosis, skin tuberculosis, adrenal tuberculosis, renal tuberculosis, epididymal tuberculosis, lymph node tuberculosis, laryngeal tuberculosis, middle ear tuberculosis, intestinal tuberculosis, multidrug-resistant tuberculosis, pulmonary tuberculosis, sputum tuberculosis, bone tuberculosis, throat tuberculosis, lymphatic gland tuberculosis, lung deficiency, breast tuberculosis or spinal tuberculosis.

6 . A method for inhibiting the survival or proliferation of Mycobacterium tuberculosis , comprising inducing the polarization of macrophages into M1 macrophages using the composition of claim 1 .

7 . The method of claim 6 , wherein the survival or proliferation of Mycobacterium tuberculosis is inhibited by inducing the polarization of macrophages into M1 macrophages by the composition, and thereafter inducing apoptosis of the macrophages upon infection with Mycobacterium tuberculosis.

Assignees

• Iac In Nat Univ Chungnam

Inventors

• Song Chang-Hwa

Classifications

• A61K31/133

  having hydroxy groups, e.g. sphingosine · CPC title

• A61K31/4965

  Non-condensed pyrazines · CPC title

• A61K31/4409

  only substituted in position 4, e.g. isoniazid, iproniazid · CPC title

• A61P31/06

  for tuberculosis · CPC title

• A61K31/496

  Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin · CPC title