System and method for sequestered wash buffer reuse
US-2024326038-A1 · Oct 3, 2024 · US
US2019291107A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2019291107-A1 |
| Application number | US-201615774440-A |
| Country | US |
| Kind code | A1 |
| Filing date | Nov 22, 2016 |
| Priority date | Nov 24, 2015 |
| Publication date | Sep 26, 2019 |
| Grant date | — |
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A low-voltage microfluidic valve device and system for regulating the flow of fluid. One low-voltage microfluidic valve device for regulating the low of fluid includes a nano-textured dendritic metallic filament configured to grow and retract in response to a voltage. The low-voltage microfluidic valve device also includes a microfluidic channel configured to allow fluid flow, wherein the fluid flow is selectively interrupted by the growth of the nano-textured dendritic metallic filament. The low-voltage microfluidic valve device also includes a membrane positioned proximate to the fluid and configured to alter shape in response to the growth of the nano-textured dendritic metallic filament.
Opening claim text (preview).
What is claimed is: 1 . A low-voltage microfluidic valve device for regulating the flow of a fluid, the device comprising: a nano-textured dendritic metallic filament configured to grow and retract in response to a voltage; a membrane positioned proximate to the fluid and configured to alter shape in response to the growth of the nano-textured dendritic metallic filament; and a microfluidic channel configured to allow fluid flow, wherein the fluid flow is selectively interrupted by the membrane when the shape is altered by the growth of the nano-textured dendritic metallic filament. 2 . The low-voltage microfluidic valve device of claim 1 , wherein the membrane is configured to isolate the fluid from an underlying metal and solid electrolyte. 3 . The low-voltage microfluidic valve device of claim 2 , wherein the underlying metal and solid electrolyte is constructed of chalcogenide. 4 . The low-voltage microfluidic valve device of claim 1 , further comprising a power supply for providing the voltage to the nano-textured dendritic metallic filament. 5 . The low-voltage microfluidic valve device of claim 4 , wherein the power supply is a direct current power supply. 6 . The low-voltage microfluidic valve device of claim 1 , wherein the growth and retraction of the nano-textured dendritic metallic filament is based on a reversible petal effect that controls the fluid flow. 7 . The low-voltage microfluidic valve device of claim 1 , wherein the nano-textured dentritic metallic filament is configured to grow in response to a positive direct current voltage and wherein the nano-textured dentritic metallic filament is configured to retract in response to a negative direct current voltage. 8 . The low-voltage microfluidic valve device of claim 1 , further comprising a first electrode and a second electrode opposite the first electrode, and wherein the nano-textured dendritic metallic filament is configured to grow and retract in response to a voltage applied across the first electrode and the second electrode. 9 . The low-voltage microfluidic valve device of claim 8 , wherein the first electrode is constructed of silver and the second electrode is constructed of nickel, and wherein the nano-textured dendritic metallic filament is configured to grow and retract from the second electrode in response to a voltage applied across the first electrode and the second electrode. 10 . The low-voltage microfluidic valve device of claim 1 , wherein the microfluidic channel is enclosed by the membrane and a polydimethylsiloxane (PDMS) membrane and wherein the microfluidic channel is 25 μm in depth. 11 . A system of regulating a flow of a fluid, the system comprising: a low-voltage microfluidic valve device, the low-voltage microfluidic valve device including a first electrode and a second electrode opposite the first electrode, a nano-textured dendritic metallic filament configured to grow and retract, a membrane positioned proximate to the fluid and configured to alter shape in response to the growth of the nano-textured dendritic metallic filament, and a microfluidic channel configured to allow fluid flow, wherein the fluid flow is selectively interrupted by the membrane when the shape is altered by the growth of the nano-textured dendritic metallic filament; and a power supply, wherein the power supply is configured to provide the voltage across the first electrode and the second electrode of the low-voltage microfluidic valve device. 12 . The system of claim 11 , wherein the low-voltage microfluidic valve device further includes an underlying metal and solid electrolyte. 13 . The system of claim 12 , wherein the membrane is configured to isolate the fluid from the underlying metal and solid electrolyte. 14 . The system of claim 12 , wherein the underlying metal and solid electrolyte is constructed of silver-doped chalcogenide. 15 . The system of claim 11 , wherein the nano-textured dendritic metallic filament is configured to grow and retract in response to the voltage applied across the first electrode and the second electrode. 16 . The system of claim 11 , wherein the growth and retraction of the nano-textured dendritic metallic filament is based on a reversible petal effect that controls the fluid flow through the microfluidic channel. 17 . The system of claim 11 , wherein the nano-textured dentritic metallic filament is configured to grow in response to a positive voltage and wherein the nano-textured dentritic metallic filament is configured to retract in response to a negative voltage. 18 . The system of claim 11 , wherein the first electrode is constructed of silver and the second electrode is constructed of nickel, and wherein the nano-textured dendritic metallic filament is configured to grow and retract from the second electrode in response to a voltage applied across the first electrode and the second electrode.
Valves using channel deformation · CPC title
Chemistry or biology, e.g. "lab-on-a-chip" technology · CPC title
Electric operating means therefor · CPC title
using photolithography, e.g. etching · CPC title
Specific details about materials · CPC title
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