Antimicrobial dental restoratives containing coconut oil and/or derivatives of coconut oil

Patent metadata

Field	Value
Publication number	US-2019247282-A1
Application number	US-201815897724-A
Country	US
Kind code	A1
Filing date	Feb 15, 2018
Priority date	Feb 15, 2018
Publication date	Aug 15, 2019
Grant date	—

Abstract

A dental restorative based on a cured dental composite containing coconut oil and/or a derivative of coconut oil. The dental restorative also includes a polymerizable monomer, a filler, and a polymerization initiator. Methods of preventing or reducing growth of microorganisms and inhibiting formation of biofilms are also described.

First claim

1 : A dental composite, comprising:
a polymerizable monomer; a filler in an amount of 40-75 wt %; a polymerization initiator; and coconut oil and/or a derivative of coconut oil in an amount ranging from 0.1 wt % to 20 wt %; wherein the weight percentages are based on a total weight of the dental composite.

2 : The dental composite of claim 1 , wherein the derivative of coconut oil is present, and is at least one selected from the group consisting of lauric acid, caprylic acid, capric acid, myristic acid, oleic acid, esters thereof, and salts thereof.

3 : The dental composite of claim 2 , wherein the derivative of coconut oil is lauric acid, an ester thereof, or a salt thereof.

4 : The dental composite of claim 1 , consisting essentially of:
the polymerizable monomer; the filler in an amount of 40-75 wt %; the polymerization initiator; and coconut oil in an amount ranging from 0.1 wt % to 20 wt %; wherein the weight percentages are based on a total weight of the dental composite.

5 : The dental composite of claim 1 , wherein the polymerizable monomer is at least one selected from the group consisting of a methacrylate monomer, an acrylate monomer, an epoxy monomer, and a vinyl monomer.

6 : The dental composite of claim 5 , wherein the polymerizable monomer is a methacrylate monomer.

7 : The dental composite of claim 6 , wherein the methacrylate monomer is at least one selected from the group consisting of bisphenol A-glycidyl methacrylate (bis-GMA), urethane dimethacrylate (UDMA), triethylene glycol dimethacrylate (TEGDMA), ethoxylated bisphenol A dimethacrylate (EBPADMA), and 2-hydroxyethyl methacrylate (HEMA).

8 : The dental composite of claim 1 , wherein the filler is at least one selected from the group consisting of a glass filler, a ceramic filler, and a polymer-based filler.

9 : The dental composite of claim 1 ., wherein the filler is at least one selected from the group consisting of silica, zirconia, and aluminosilicate.

10 : The dental composite of claim 1 , wherein the polymerization initiator is a free radical initiator.

11 : The dental composite of claim 10 , wherein the free radical initiator is at least one selected from the group consisting of camphorquinone, an acyl phosphine oxide, an azo compound, and an organic peroxide. claim 12 : A dental restoration, comprising a cured dental composite of claim 1 .

13 : The dental restoration of claim 12 , which has a flexural strength of about 70 MPa to about 150 MPa.

14 : The dental restoration of claim 12 , which has a Vickers hardness number HV of about 60 to about 100.

15 : A method of preventing or reducing growth of a microorganism in an oral cavity, the method comprising applying the dental restoration of claim 12 to the oral cavity of a subject in need thereof.

16 : The method of claim 15 , wherein the microorganism is at least one selected from the group consisting of Streptococcus mutans and Streptococcus sobrinus.

17 : The method of claim 15 , wherein preventing or reducing growth of the microorganism in the oral cavity is evaluated by measuring a microbial count.

18 : A method of inhibiting formation of a biofilm on a surface in an oral cavity, the method comprising applying the dental restoration of claim 12 to the surface in the oral cavity of a subject in need thereof.

19 : The method of claim 18 , wherein the biofilm comprises at least one selected from the group consisting of Streptococcus mutans and Streptococcus sobrinus.

20 : The method of claim 18 , wherein the surface is a tooth surface.

Assignees

• Univ Imam Abdulrahman Bin Faisal

Inventors

• Alsheikh Rasha Numan Ali
• Almasoud Naif Nasser

Classifications

• A61K6/77

  Glass · CPC title

• A61K6/887

  Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• A61K6/71

  Fillers · CPC title

• A61K6/76

  comprising silicon-containing compounds · CPC title

• A61K31/20 Primary

  having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids · CPC title