Antimicrobial wound care dressing

Patent metadata

Field	Value
Publication number	US-2019247234-A1
Application number	US-201716343214-A
Country	US
Kind code	A1
Filing date	Oct 20, 2017
Priority date	Oct 21, 2016
Publication date	Aug 15, 2019
Grant date	—

Abstract

Antimicrobial dressings for prevention and mitigation of biofilm and bacterial infection by an applied electric current are provided. Methods of making the dressings and methods of applying an electric current to promote the wound healing process are also disclosed.

First claim

1 . An antimicrobial dressing for a wound comprising:
a substrate; at least one pair of electrodes positioned on or within the substrate, wherein the pair of electrodes comprise a conductive anode in contact with at least a first portion of the wound and a conductive cathode in contact with at least a second portion of the wound; and an energy source connected to at least one electrode pair, wherein the energy source induces an electrical current to flow from the conductive anode, through the wound, to the conductive cathode.

2 . (canceled)

3 . (canceled)

4 . The antimicrobial dressing of claim 1 , wherein the substrate is comprised of material that is substantially electrically insulating.

5 . (canceled)

6 . The antimicrobial dressing of claim 1 , wherein the substrate is comprised of silk and the silk comprises Habotai silk.

7 . (canceled)

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26 . The antimicrobial dressing of claim 40 , wherein a first subset of the plurality of electrodes are connected in electrical series with the anode and a second set of the plurality of electrodes are connected in electrical series with the cathode and the plurality of electrodes are comprised of a biocompatible reduction/oxidation reaction material such that a voltage differential is created between the anode and the cathode, wherein said voltage differential causes the electrical current to flow from the conductive anode, through the wound, to the conductive cathode.

27 . The antimicrobial dressing of claim 26 , wherein the biocompatible reduction/oxidation reaction materials comprises silver and zinc such that the first subset of the plurality of electrodes are comprised of silver and the second subset of the plurality of electrodes are comprised of zinc.

28 . (canceled)

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33 . The antimicrobial dressing of claim 1 , further comprising a current-limiting element, wherein the current limiting element limits the electrical current flowing from the conductive anode, through the wound, to the conductive cathode to a desired range.

34 . The antimicrobial dressing of claim 33 , wherein the desired range of the current flowing through the wound is 15 milliamps, or less.

35 . (canceled)

36 . The antimicrobial dressing of claim 33 , wherein the current limiting element limits the current such that an unacceptable level of heating caused by the electrical current flowing from the conductive anode, through the wound, to the conductive cathode is not experienced.

37 . The antimicrobial dressing of claim 36 , wherein a power density applied to the wound is at or below approximately 0.25 W/cm 2 to avoid the unacceptable levels of heating caused by the electrical current flowing from the conductive anode, through the wound, to the conductive cathode.

38 . The antimicrobial dressing of claim 1 , further comprising a voltage indicator or a current indicator, wherein the voltage indicator indicates voltage being provided by the energy source connected to the at least one electrode pair and wherein the current indicator indicates a presence of the electrical current flowing from the conductive anode, through the wound, to the conductive cathode.

39 . (canceled)

40 . The antimicrobial dressing of claim 1 , further comprising a plurality of electrodes in a spaced pattern on the substrate that are electrically isolated from one another on the substrate and are in contact with the wound, the plurality of electrodes comprised of a biocompatible reduction/oxidation reaction material such that an electrical field is created in the wound by the plurality of electrodes thus facilitating wound healing.

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51 . The antimicrobial dressing of claim 1 , further comprising a sensor, wherein the sensor measures impedance through the wound or eddy current in the wound, which is used to determine healing of the wound.

52 . A method of treating a bacterial infection in a wound, the method comprising:
applying an antimicrobial dressing to the wound; and applying a therapeutically effective amount of an electric current to the wound from the antimicrobial dressing.

53 . The method of claim 52 , wherein the antimicrobial dressing for a wound comprises a substrate; at least one pair of electrodes positioned on or within the substrate, wherein the pair of electrodes comprise a conductive anode in contact with at least a first portion of the wound and a conductive cathode in contact with at least a second portion of the wound; and an energy source connected to at least one electrode pair, wherein the energy source induces an electrical current to flow from the conductive anode, through the wound, to the conductive cathode.

54 . The method of claim 52 , wherein the method is used to inhibit or disrupt bacterial growth in the wound or inhibit or disrupt biofilm in the wound.

55 . A method of assembling an antimicrobial dressing, comprising:
applying a layer of conductive material to an insulated base substrate to form at least one electrode pair on the insulated base substrate, wherein the pair of electrodes comprise a conductive anode and a conductive cathode that are electrically insulated from one another, wherein an energy source is connected to the at least one electrode pair, wherein the energy source induces an electrical current to flow from the conductive anode, through a wound, to the conductive cathode.

56 . (canceled)

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65 . The method of claim 55 , wherein the at least one of the conductive anode and the conductive cathode are printed on the substrate using screen-printing techniques or are printed on the substrate using a printer.

66 . The method of claim 55 , wherein at least one of the conductive anode and the conductive cathode are woven into the substrate.

67 . (canceled)

68 . (canceled)

69 . The method of claim 55 , further comprising forming a plurality of electrodes in a spaced pattern on the substrate, wherein t

Assignees

• Ohio State Innovation Foundation

Inventors

• Prakash Shaurya
• Subramaniam Vishwanath V
• Bennett Molly Marie
• Sen Chandan K
• Jones Travis Hamilton
• Rosenthal Emily Quinn
• Steiner Shomita
• Roy Sashwati
• West Joseph Dean
• Ghatak Piya Das

Classifications

• A61N1/0468

  Specially adapted for promoting wound healing · CPC title

• A61N1/32

  alternating or intermittent currents {(applying electric fields by inductive or capacitive coupling A61N1/40; microwave apparatus A61N5/02)} · CPC title

• A61N1/205

  for promoting a biological process · CPC title

• A61F13/00051

  Accessories for dressings · CPC title

• A61N1/0484

  Garment electrodes worn by the patient · CPC title