Degradable bulk metallic magnesium/polymer composite barrier membranes for dental, craniomaxillofacial and orthopedic applications and manufacturing methods

Patent metadata

Field	Value
Publication number	US-2019240374-A1
Application number	US-201716341977-A
Country	US
Kind code	A1
Filing date	Oct 23, 2017
Priority date	Oct 21, 2016
Publication date	Aug 8, 2019
Grant date	—

Abstract

The invention relates to magnesium reinforcements and magnesium-reinforced barrier membranes for use in biomedical applications, such as dental, craniofacial and orthopedic applications. The magnesium reinforcements and barrier membranes are composed of a biodegradable, magnesium/polymer composite. They can be used in a wide variety of applications, such as, but not limited to, vertical and horizontal ridge augmentation, guided bone/tissue regeneration, periodontal bone regeneration, fracture fixation and orthopedic and spinal bone grafting applications; as well as in general surgery (hernia repair) and urogynecological surgery.

First claim

We claim:

1 . A method of preparing a biodegradable, magnesium-reinforced polymer composite implant device, comprising:
selecting bulk magnesium; selecting a polymer sheet; processing the bulk magnesium to form a pre-determined geometry having a surface, employing a process selected from the group consisting of expanded metal processing and laser cutting; and applying the polymer sheet onto the surface of the pre-determined geometry.

2 . The method of claim 1 , wherein the predetermined geometry is selected from the group consisting of a mesh, strut and strut-style support.

3 . The method of claim 1 , wherein the bulk magnesium is in a form selected from the group consisting of foil and sheet.

4 . The method of claim 1 , wherein the surface comprises an upper surface and a lower surface, and the applying the polymer sheet is onto one or more of the upper and lower surfaces.

5 . The method of claim 4 , wherein the applying the polymer sheet comprises melting a first polymer sheet onto the upper surface and a second polymer sheet onto the lower surface, wherein the first polymer sheet is the same as, or different from, the second polymer sheet.

6 . The method of claim 5 , further comprising obtaining a polymer in dry form and integrating the polymer in dry form into the pre-determined geometry, wherein the integrating is conducted prior to the melting of the first and second polymer sheets.

7 . The method of claim 6 , wherein the integrating comprises embedding the polymer in dry form within a plane of a magnesium mesh having pores or open spaces formed therein.

8 . The method of claim 6 , wherein the integrating comprises depositing the polymer in dry form along a perimeter of a magnesium strut.

9 . The method of claim 1 , wherein the applying the polymer sheet employs a process selected from the group consisting of compression molding and laminating.

10 . A biodegradable, magnesium-reinforced polymer composite, comprising:
a magnesium framework having a surface, in a form selected from the group consisting of mesh, strut and strut-style support; and a polymer sheet applied to the surface of the magnesium framework.

11 . The composite of claim 10 , wherein the mesh comprises polymer in dry form embedded in pores and openings formed in the mesh.

12 . The composite of claim 10 , wherein the strut comprises polymer in dry form formed along a perimeter of the strut.

13 . The composite of claim 10 , wherein the polymer sheet is selected from the group consisting of low molecular weight poly(lactic-co-glycolic acid), high molecular weight poly(lactic-co-glycolic acid), poly-L-lactic acid, poly-D-lactic acid, polyethylene glycol, and blends and mixtures thereof.

14 . The composite of claim 10 , wherein said composite is a biomedical implant device for applications selected from the group consisting of dental, craniofacial and orthopedic applications.

15 . The composite of claim 14 , wherein said applications include containing bone graft material and fixating complex craniofacial bone fractures.

Assignees

• Univ Pittsburgh Commonwealth Sys Higher Education

Inventors

• Brown Andrew
• Sfeir Charles

Classifications

• A61K6/84

  comprising metals or alloys · CPC title

• A61K6/891

  Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• A61L27/047 Primary

  Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06 · CPC title

• A61F2/2846

  Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects (nets or sleeves applied to surface of endoprostheses A61F2/30907; bone plates A61B17/80; bone regeneration in dental surgery A61C8/0006) · CPC title

• A61L2420/02

  Methods for coating medical devices · CPC title