Apparatus for providing automated peritoneal dialysis

Patent metadata

Field	Value
Publication number	US-2019201607-A1
Application number	US-201716329981-A
Country	US
Kind code	A1
Filing date	Aug 28, 2017
Priority date	Sep 2, 2016
Publication date	Jul 4, 2019
Grant date	—

Abstract

An apparatus peritoneal dialysis ( 1 ) comprising an automated peritoneal dialysis cycler ( 3 ) programmed to run a treatment session including a plurality of cycles, each cycle including a fill phase, a dwell phase and a drain phase of a peritoneal cavity of a patient (P), the treatment session lasting at most 720 min; the cycler ( 3 ) has a patient line ( 54 ) in communication with the patient (P), a source (S) of treatment fluid which includes an osmotic agent, a pump ( 5 ) to circulate the treatment fluid and a control system ( 74 ) configured to drive the cycler ( 3 ) to deliver the treatment session. The control system ( 74 ) is programmed to run a fill phase of a first cycle delivering a first treatment fluid to the patient, the first treatment fluid having a first concentration of the osmotic agent; subsequently to the first cycle, to run a fill phase of a second cycle delivering a second treatment fluid to the patient, the second treatment fluid having a second concentration of the osmotic agent different from the concentration of the first treatment fluid; subsequently to the second cycle, to run a fill phase of a third cycle delivering a third treatment fluid to the patient, the third treatment fluid having a third concentration of the osmotic agent different from the concentration of the second treatment fluid. The second concentration of the osmotic agent is lower than the first concentration of the osmotic agent and the third concentration of osmotic agent is higher than the second concentration of osmotic agent.

First claim

1 - 25 . (canceled)

26 . An apparatus for peritoneal dialysis comprising:
an automated peritoneal dialysis cycler programmed to run a treatment session including a plurality of cycles, each cycle including a fill phase, a dwell phase, and a drain phase of a peritoneal cavity of a patient, the treatment session lasting at most 720 min, the cycler having:
a patient line configured to be placed in communication with the peritoneal cavity of the patient;
at least a source of treatment fluid which includes an osmotic agent; and
at least one pump to circulate the treatment fluid to be delivered to the patient through said patient line; and
a control system configured to drive said cycler to deliver the treatment session, wherein, during the same treatment session, the control system configured to:
run a fill phase of a first cycle delivering a first treatment fluid to the patient, the first treatment fluid having a first concentration of the osmotic agent;
subsequently to the first cycle, run a fill phase of a second cycle delivering a second treatment fluid to the patient, the second treatment fluid having a second concentration of the osmotic agent different from the concentration of the first treatment fluid; and
subsequently to the second cycle, run a fill phase of a third cycle delivering a third treatment fluid to the patient, the third treatment fluid having a third concentration of the osmotic agent different from the concentration of the second treatment fluid,

wherein the second concentration of the osmotic agent is lower than the first concentration of the osmotic agent and the third concentration of osmotic agent is higher than the second concentration of osmotic agent, or wherein the second concentration of the osmotic agent is higher than the first concentration of the osmotic agent and the third concentration of osmotic agent is lower than the second concentration of osmotic agent.

27 . The apparatus according to claim 26 , wherein the osmotic agent is, or includes, glucose, L-carnitine, glycerol, or combinations thereof, in particular the osmotic agent being or including glucose.

28 . The apparatus according to claim 26 , wherein the control system is programmed to run the first cycle followed by one or more additional cycles before running the second cycle and/or wherein the control system is programmed to run the second cycle followed by one or more additional cycles before running the third cycle.

29 . The apparatus according to claim 26 , wherein the control system is programmed to run the first cycle immediately followed by the second cycle and/or wherein the control system is programmed to run the second cycle immediately followed by the third cycle.

30 . The apparatus according to claim 26 , wherein, during the same treatment session, the control system delivers a plurality of cycles using a treatment fluid with high concentration of osmotic agent, alternating with a plurality of cycles using a treatment fluid with low or no concentration of osmotic agent, said high concentration of osmotic agent being higher than said low concentration of osmotic agent.

31 . The apparatus according to the claim 30 , wherein the treatment fluid with high concentration of osmotic agent includes a concentration of osmotic agent equal to or higher than 3% by weight, optionally equal to or higher than 4% by weight, and in more detail equal to or higher than 5% by weight, said osmotic agent being in particular glucose.

32 . The apparatus according to claim 30 , wherein the treatment fluid with low concentration of osmotic agent includes a concentration of osmotic agent equal to or lower than 2% by weight, optionally equal to or lower than 1.5% by weight, and in more detail equal to or lower than 0.5% by weight, said osmotic agent being in particular glucose.

33 . The apparatus according to claim 30 , wherein during said plurality of cycles using a treatment fluid with high concentration of osmotic agent alternating with said plurality of cycles using a treatment fluid with low or no concentration of osmotic agent, the cycle using a treatment fluid with high concentration of osmotic agent is followed by one or more subsequent cycles before the cycle using a treatment fluid with low or no concentration of osmotic agent.

34 . The apparatus according to claim 30 , wherein during said plurality of cycles using a treatment fluid with high concentration of osmotic agent alternating with said plurality of cycles using a treatment fluid with low or no concentration of osmotic agent, the cycle using a treatment fluid with low or no concentration of osmotic agent is followed by one or more subsequent cycles before the cycle using a treatment fluid with high concentration of osmotic agent.

35 . The apparatus according to claim 30 , wherein during said plurality of cycles using a treatment fluid with high concentration of osmotic agent alternating with said plurality of cycles using a treatment fluid with low or no concentration of osmotic agent, the cycle using a treatment fluid with high concentration of osmotic agent is immediately followed by the cycle using a treatment fluid with low or no concentration of osmotic agent.

36 . The apparatus according to claim 30 , wherein during said plurality of cycles using a treatment fluid with high concentration of osmotic agent alternating with said plurality of cycles using a treatment fluid with low or no concentration of osmotic agent, the cycle using a treatment fluid with low or no concentration of osmotic agent cycle is immediately followed by the cycle using a treatment fluid with high concentration of osmotic agent.

37 . The apparatus according to claim 26 , wherein the control system is configured to leave the treatment fluid in the peritoneal cavity for a dwell time, the dwell time of a treatment fluid with higher osmotic agent concentration being different from, and in particular lower than, a dwell time of a treatment fluid with lower or no osmotic agent concentration.

38 . The apparatus according to claim 26 , wherein the cycler includes at least two sources of treatment fluid, each source being configured for feeding a treatment fluid that differs from a treatment fluid of another source, the treatment fluids differing at least by the concentration of the osmotic agent, in particular each source being a respective treatment fluid bag.

39 . The apparatus according to claim 26 , wherein the cycler includes a disposable unit including said patient line configured to be connected to the patient and a peritoneal dialysis unit including said pump and a compartment configured to receive the disposable unit, the pump being arranged so that when the disposable unit is disposed within the compartment, the pump cooperates with the disposable unit to deliver the treatment fluid to and drain the treatment fluid from the peritoneal cavity of the patient via the patient line of the disposable unit.

40 . The apparatus according to claim 39 , wherein the disposable unit includes at least one inlet port connected to a source of treatment fluid and at least one container configured for receiving the treatment fluid from the source, in particular the cycler being configured to heat the treatment fluid in the container for receiving the treatment fluid before delivering the treatment fluid to the patient via the patient line.

41 . The apparatus according to claim 39 , wherein the disposable unit includes at least two inlet ports, said inlet ports being respectively connected to sources of treatment fluid having different concentrations of osmotic

Assignees

• Gambro Lundia Ab

Inventors

• Öberg Carl

Classifications

• G16H20/40

  relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture · CPC title

• A61M1/282 Primary

  Operational modes · CPC title

• A61M2202/0486

  Glucose · CPC title

• A61M1/281

  Instillation other than by gravity · CPC title

• A61M1/287

  Dialysates therefor · CPC title