Colloidal antimicrobial and anti-biofouling coatings for surfaces

Patent metadata

Field	Value
Publication number	US-2019174749-A1
Application number	US-201716310631-A
Country	US
Kind code	A1
Filing date	Jun 30, 2017
Priority date	Jun 30, 2016
Publication date	Jun 13, 2019
Grant date	—

Abstract

Methods and formulations for antimicrobial and anti-biofouling coating comprising: a hollow round colloidal structure, comprising: an active polymer shell; and an active or inert core; wherein the active polymer shell comprises one and more polymers with antimicrobial and anti-biofouling activities selected from the group consisting of polyethylenimine (PEI), functionalized chitosan (CHI), polyquaternium, poly(diallyldimethylammonium chloride) (PDDA) and polyhexamethylene biguanide (PHMD); wherein the active or inert core contains one and more disinfectants, biocides, fragrances or inert solvent; and wherein the hollow round colloidal structure is stable for at least 3 months.

First claim

What is claimed is:

1 . An antimicrobial and anti-biofouling coating formulation, comprising:
a hollow round colloidal structure, comprising: c) an active polymer shell; and d) an active or inert core; wherein the active polymer shell comprises one and more polymers with antimicrobial and anti-biofouling activities selected from the group consisting of polyethylenimine (PEI), functionalized chitosan (CHI), polyquaternium, poly(diallyldimethylammonium chloride) (PDDA) and polyhexamethylene biguanide (PHMD); wherein the core is active and contains one or more disinfectants, biocides- and fragrances; wherein the core is inert and contains water or inert solvent; and wherein the hollow round colloidal structure is stable for at least 3 months.

2 . The coating according to claim 1 , wherein the polymer is PEI.

3 . The coating according to claim 1 , wherein the polymer is PHMD.

4 . The coating according to claim 1 , wherein the one or more polymers are PEI and PHMD.

5 . The coating according to claim 1 , wherein the one or more polymers are PEI and PDDA.

6 . The coating according to claim 1 , wherein the one or more polymers are PHMD and PDDA.

7 . The coating according to claim 1 , wherein the one or more polymers are PEI, PHMD and PDDA.

8 . The coating formulation according to claim 1 , wherein the one or more polymers are present in a concentration of 0.5-100 wt % of the polymer shell.

9 . The coating formulation according to claim 8 , wherein the one or more polymers are present in a concentration of 10-20 wt % of the polymer shell.

10 . The coating formulation according to claim 1 , wherein the core is an active core comprising one or more biocides selected from the group consisting of essential oil, polyol and aldehyde.

11 . The coating formulation according to 10, wherein the biocide is an essential oil and the essential oil is thyme oil.

12 . The coating formulation according to claim 10 , wherein the biocide is a polyol and the polyol is farnesol.

13 . The coating formulation according to claim 10 , wherein the biocide is an aldehyde and the aldehyde is cinnamaldehyde.

14 . The coating formulation according to claim 10 , wherein the one or more biocides comprises an essential oil and the essential oil is thyme oil, a polyol and the polyol is farnesol and an aldehyde and the aldehyde is cinnamaldehyde.

15 . The coating formulation according to claim 1 , wherein the active polymer shell comprises 0.0001-5% (w/v) PEI having a mw of 1,200-60,000 g/mol, 0.05-3% (w/v) PHMD having a mw of 2,000-2,600 g/mol and 0.01-20% (w/v) of PDDA having a mw of 250,000-350,000 g/mol; and wherein the active core contains 0.01-1.5% (w/v) of thyme oil, 0.01-1.5% (w/v) of farnesol, 0.05-1.5% (w/v) of cinnamaldehyde.

16 . The coating formulation of claim 1 , wherein the coating formulation further comprises stabilizers.

17 . The coating formulation of claim 15 , wherein the coating formulation further comprising: 0.01-20% (w/v) of polyvinyl alcohol having a mw 31,000-186,000 g/mol; 0.01-20% (w/v) of PEGMA having a Mn of 500 and 0.01-20% (w/v) of MPEGMA having a Mn of 950.

18 . A method of producing antimicrobial and anti-biofouling coating for application to nonporous surfaces, porous membranes or porous materials, comprising:
preparing an antimicrobial and anti-fouling formulation by the steps of:
(e) preparing an aqueous solution containing one or more active polymers;
(f) adding biocides or solvents into the aqueous solution of active polymers;
(g) preparing an emulsion having a hollow round colloidal structure comprising adding a stabilizer mixture containing one and more surfactants to the biocides or solvents and solution of active polymers to form the antimicrobial and anti-biofouling formulation; and
(h) preparing the antimicrobial and anti-biofouling coating from the antimicrobial and anti-biofouling formulation; and
applying the antimicrobial and anti-biofouling coating on nonporous surfaces, porous membranes or porous materials.

19 . The method according to claim 18 , wherein the nonporous surfaces are stainless steel, glass and polyvinyl chloride surfaces.

20 . The method according to claim 18 , wherein the porous membranes are selected from the group consisting of reverse osmosis membranes, nanofiltration membranes, ultrafiltration membranes, microfiltration membranes and high-efficiency particulate air filters.

21 . The method according to claim 18 , wherein the porous materials are nonwoven and woven fabric materials.

22 . The method according to claim 18 , wherein the surfactants are polyvinyl alcohol and polyethylene glycol.

23 . The method according to claim 18 , wherein applying the antimicrobial and anti-biofouling coating comprises at least one of wiping, brushing, casting, dip-coating, wash-coating, spin-coating, spray-coating and layer-by-layer coating the antimicrobial and anti-biofouling formulation onto nonporous surfaces, porous membranes or porous materials.

24 . The method according to claim 18 , wherein applying the antimicrobial and anti-biofouling coating comprises incorporating the antimicrobial and anti-biofouling formulation into a paint or an epoxy resin for direct application on nonporous surfaces, porous membranes or porous materials.

25 . The method according to claim 18 , wherein applying the antimicrobial and anti-biofouling coating on porous membranes further comprises rejecting round colloids on the surfaces of porous membranes by a further filtration method thereby forming a reversible coating.

Assignees

• Univ Hong Kong Sci & Tech

Inventors

• Yeung King Lun
• Zhang Hanrong
• Li Ying
• Farid Awais

Classifications

• A01N33/12

  Quaternary ammonium compounds · CPC title

• D06M15/263

  of unsaturated carboxylic acids; Salts or esters thereof · CPC title

• A01N49/00

  Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group [IMAGE cpc-sch-A01N-0948.gif], wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group [IMAGE cpc-sch-A01N-0949.gif], wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof (containing hydrocarbons A01N27/00) · CPC title

• A01N33/04

  Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms · CPC title

• D06M16/00

  Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic · CPC title