Impulse rescan system

Patent metadata

Field	Value
Publication number	US-2019166293-A1
Application number	US-201816206631-A
Country	US
Kind code	A1
Filing date	Nov 30, 2018
Priority date	Nov 30, 2017
Publication date	May 30, 2019
Grant date	—

Abstract

A digital pathology scanning apparatus is configured to initiate a rescan of a portion of a sample responsive to detecting a mechanical vibration during image acquisition that exceeds a predetermined threshold. The digital pathology scanning apparatus includes a plurality of sensors and a processor that analyzes sensor data received during movement of a scanning stage supporting a sample during image acquisition. The processor is configured to identify a mechanical vibration imparted on the scanning stage during image acquisition and determine if the mechanical vibration exceeds a predetermined threshold. If the predetermined threshold is exceeded, the processor is configured to initiate a rescan of the portion of the sample being scanned at the time of the mechanical vibration.

First claim

What is claimed is:

1 . A digital pathology scanning apparatus, comprising:
a scanning stage configured to support a sample and move the sample in a controlled direction relative to an imaging system to digitize a portion of the sample; one or more sensors configured to generate sensor data during movement of the scanning stage in the controlled direction; a processor configured to control movement of the scanning stage in the controlled direction and further configured to analyze sensor data generated by the one or more sensors during movement of the scanning stage in the controlled direction, the processor further configured to:
identify an event in the sensor data based on one or more of a duration and a distance of a detected movement of the scanning stage in a non-controlled direction during movement of the scanning stage in the controlled direction, and
if an identified event exceeds a predetermined threshold, initiate a re-scan of the portion of the sample being scanned when the identified event occurred.

2 . The digital pathology scanning apparatus of claim 1 , wherein the one or more sensors comprise position encoders that operate in cooperation with the processor to control movement of the scanning stage in the controlled direction.

3 . The digital pathology scanning apparatus of claim 1 , wherein the one or more sensors comprise an accelerometer configured to detect a movement of the scanning stage in the non-controlled direction.

4 . The digital pathology scanning apparatus of claim 1 , wherein the predetermined threshold is based solely on a duration of a detected movement in a non-controlled direction.

5 . The digital pathology scanning apparatus of claim 1 , wherein the predetermined threshold is based solely on a distance of a detected movement in a non-controlled direction.

6 . The digital pathology scanning apparatus of claim 1 , wherein the predetermined threshold is based a combination of a distance of a detected movement in a non-controlled direction and a duration of a detected movement in a non-controlled direction.

7 . A method comprising:
moving a scanning stage in a controlled direction relative to an imaging system; digitizing a portion of a sample supported by the scanning stage during said movement of the scanning stage in the controlled direction; using one or more sensors to generate sensor data during said movement of the scanning stage in the controlled direction; analyzing the sensor data generated by the one or more sensors during movement of the scanning stage in the controlled direction; identifying an event in the sensor data based on the analysis, wherein the event comprises a one or more of a duration and a distance of a detected movement of the scanning stage in a non-controlled direction during movement of the scanning stage in the controlled direction, and initiating a re-digitizing of the portion of the sample being digitized by the imaging system when the identified event occurred if the identified event exceeds a predetermined threshold.

8 . The method of claim 7 , wherein the one or more sensors comprise position encoders that operate in cooperation with a processor to control movement of the scanning stage in the controlled direction.

9 . The method of claim 7 , wherein the one or more sensors comprise an accelerometer configured to detect a movement of the scanning stage in the non-controlled direction.

10 . The method of claim 7 , wherein the predetermined threshold is based solely on a duration of a detected movement in a non-controlled direction.

11 . The method of claim 7 , wherein the predetermined threshold is based solely on a distance of a detected movement in a non-controlled direction.

12 . The method of claim 7 , wherein the predetermined threshold is based a combination of a distance of a detected movement in a non-controlled direction and a duration of a detected movement in a non-controlled direction.

13 . A non-transitory computer readable medium having stored thereon one or more sequences of instructions for causing one or more processors to perform the steps comprising:
moving a scanning stage in a controlled direction relative to an imaging system; digitizing a portion of a sample supported by the scanning stage during said movement of the scanning stage in the controlled direction; using one or more sensors to generate sensor data during said movement of the scanning stage in the controlled direction; analyzing the sensor data generated by the one or more sensors during movement of the scanning stage in the controlled direction; identifying an event in the sensor data based on the analysis, wherein the event comprises a one or more of a duration and a distance of a detected movement of the scanning stage in a non-controlled direction during movement of the scanning stage in the controlled direction, and initiating a re-digitizing of the portion of the sample being digitized by the imaging system when the identified event occurred if the identified event exceeds a predetermined threshold.

14 . The medium of claim 13 , wherein the one or more sensors comprise position encoders that operate in cooperation with a processor to control movement of the scanning stage in the controlled direction.

15 . The medium of claim 13 , wherein the one or more sensors comprise an accelerometer configured to detect a movement of the scanning stage in the non-controlled direction.

16 . The medium of claim 13 , wherein the predetermined threshold is based solely on a duration of a detected movement in a non-controlled direction.

17 . The medium of claim 13 , wherein the predetermined threshold is based solely on a distance of a detected movement in a non-controlled direction.

18 . The medium of claim 13 , wherein the predetermined threshold is based a combination of a distance of a detected movement in a non-controlled direction and a duration of a detected movement in a non-controlled direction.

Assignees

• Leica Biosystems Imaging Inc

Inventors

• Newberg Nicholas
• Djelosevic Prentash

Classifications

• H04N23/685 Primary

  performed by mechanical compensation · CPC title

• H04N25/711

  Time delay and integration [TDI] registers; TDI shift registers · CPC title

• H04N23/67

  Focus control based on electronic image sensor signals · CPC title

• G02B21/0036

  Scanning details, e.g. scanning stages · CPC title

• G06T2207/20201

  Motion blur correction · CPC title