Boron containing small molecules as antiprotozoal agents
US-10214548-B2 · Feb 26, 2019 · US
US2019135837A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2019135837-A1 |
| Application number | US-201916241841-A |
| Country | US |
| Kind code | A1 |
| Filing date | Jan 7, 2019 |
| Priority date | Feb 1, 2013 |
| Publication date | May 9, 2019 |
| Grant date | — |
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This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.
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What is claimed is: 1 . A method of killing and/or preventing the growth of a protozoa, comprising contacting the protozoa with an effective amount of 2-chloro-N-(1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)-4-(1H-pyrazol-1-yl)benzamide, or a pharmaceutically acceptable salt thereof, thereby killing and/or preventing the growth of the protozoa. 2 . A method of killing and/or preventing the growth of a protozoa in a human, comprising administering to the human, in need of such treatment, a therapeutically effective amount of 2-chloro-N-(1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)-4-(1H-pyrazol-1-yl)benzamide, or a pharmaceutically acceptable salt thereof, thereby killing and/or preventing the growth of the protozoa. 3 . A method of killing and/or preventing the growth of a parasite in a human, comprising administering to the human, in need of such treatment, a therapeutically effective amount of 2-chloro-N-(1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)-4-(1H-pyrazol-1-yl)benzamide, or a pharmaceutically acceptable salt thereof, thereby killing and/or preventing the growth of the parasite.
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