Systems and methods comprising a droplet delivery device and a breathing assist device for therapeutic treatment

Patent metadata

Field	Value
Publication number	US-2019125987-A1
Application number	US-201716098805-A
Country	US
Kind code	A1
Filing date	May 3, 2017
Priority date	May 3, 2016
Publication date	May 2, 2019
Grant date	—

Abstract

A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.

First claim

What is claimed:

1 . A drug delivery system for administering a therapeutic agent to a subject in need thereof as an ejected stream of droplets delivered to the pulmonary system of the subject to treat a disease disorder or condition, the system comprising:
a piezoelectric actuated droplet delivery device; and a breathing assist device; wherein the droplet delivery device comprises:
a housing;
a reservoir disposed within or in fluid communication with the housing for receiving a volume of fluid including the therapeutic agent;
an ejector mechanism in fluid communication with the reservoir, the ejector mechanism comprising a piezoelectric actuator and an aperture plate, the aperture plate having a plurality of openings formed through its thickness and the piezoelectric actuator operable to oscillate the aperture plate at a frequency to thereby generate an ejected stream of droplets;
at least one differential pressure sensor positioned within the housing;
the at least one differential pressure sensor configured to activate the ejector mechanism upon sensing a pre-determined pressure change within the housing to thereby generate an ejected stream of droplets;
the ejector mechanism configured to generate the ejected stream of droplets wherein at least about 70% of the droplets have an average ejected droplet diameter of less than about 5 microns, such that at least about 70% of the mass of the ejected stream of droplets is delivered in a respirable range to the pulmonary system of a subject during use so as to treat the disease, disorder, or condition.

2 . The drug delivery system of claim 1 , wherein the breathing assist device is a mechanical ventilator or a continuous positive airway pressure (CPAP) machine.

3 . The drug delivery system of claim 1 , wherein the droplet delivery device is positioned in-line with an airflow tube of the breathing assist device to provide delivery of the ejected stream of droplets with the breathing assist device airflow.

4 . The drug delivery system of claim 1 , wherein the aperture plate of the piezoelectric actuated droplet delivery device comprises a domed shape.

5 . The drug delivery system of claim 1 , wherein the piezoelectric actuated droplet delivery device further comprises a laminar flow element located at the airflow entrance side of the housing and configured to facilitate laminar airflow across the exit side of aperture plate and to provide sufficient airflow to ensure that the ejected stream of droplets flows through the droplet delivery device during use.

6 . The drug delivery system of claim 1 , wherein the ejector mechanism is orientated with reference to the housing such that the ejected stream of droplets is directed into and through the housing at an approximate 90 degree change of trajectory prior to expulsion from the housing.

7 . The droplet delivery system of claim 1 , wherein the reservoir is removably coupled with the housing.

8 . The drug delivery system of claim 1 , wherein reservoir is coupled to the ejector mechanism to form a combination reservoir/ejector mechanism module, and the combination reservoir/ejector mechanism module is removably coupled with the housing.

9 . The drug delivery system of claim 1 , further comprising a wireless communication module.

10 . The drug delivery system of claim 9 , wherein the wireless communication module is a Bluetooth transmitter.

11 . The drug delivery system of claim 1 , wherein the piezoelectric actuated droplet delivery device further comprises one or more sensors selected from an infer-red transmitter, a photodetector, an additional pressure sensor, and combinations thereof.

12 . The drug delivery system of claim 1 , wherein the breathing assist device is a mechanical ventilator, the therapeutic agent is an antibiotic, and the disease, disorder or condition is ventilator-assisted pneumonia (VAP).

13 . The drug delivery system of claim 12 , wherein the piezoelectric actuated droplet delivery device is activated during the inspiration cycle of the mechanical ventilator.

14 . The drug delivery system of claim 1 , wherein the breathing assist device is a CPAP machine.

15 . The drug delivery system of claim 14 , further comprising a cardiac monitoring module configured to monitor and detect cardiac events, wherein the cardiac monitoring module is in communication with a controller.

16 . The drug delivery system of claim 15 , wherein the therapeutic agent is a cardiac medication, and the disease, disorder or condition is a cardiac condition.

17 . The drug delivery system of claim 16 , wherein the piezoelectric actuated droplet delivery device is activated during the inspiration cycle of a subject when the cardiac monitoring module detects a cardiac event.

18 . A method for treating a disease, condition or disorder using a drug delivery system of claim 1 .

19 . The method of claim 1 , wherein the breathing assist device is a mechanical ventilator or a continuous positive airway pressure (CPAP) machine.

20 . The method of claim 1 , wherein the disease condition or disorder is selected from VAP and cardiac events.

Assignees

• Pneuma Respiratory Inc

Inventors

• Germinario Louis Thomas
• Hebrank John H
• Hunter Charles Eric
• Stern Thomas P
• Hunter Jack C

Classifications

• G16H50/20

  for computer-aided diagnosis, e.g. based on medical expert systems · CPC title

• G16H40/63

  for local operation · CPC title

• G16H20/13

  delivered from dispensers · CPC title

• A61M16/142

  with semi-permeable walls separating the liquid from the respiratory gas · CPC title

• A61M2205/3569

  sublocal, e.g. between console and disposable · CPC title