Medical Devices

Patent metadata

Field	Value
Publication number	US-2019117827-A1
Application number	US-201816170670-A
Country	US
Kind code	A1
Filing date	Oct 25, 2018
Priority date	Oct 25, 2017
Publication date	Apr 25, 2019
Grant date	—

Abstract

A metal device that is at least partially formed of a novel alloy or composition.

First claim

What is claimed:

1 . A method of injecting a carrier that includes a substance of VGF, growth factor, stern cell, cellular material, biological material and/or pharmaceutical agents into a cavity of a bone and/or space between bone segments for purposes of a) inducing, facilitating, supporting and/or promoting bone and/or tissue growth, b) fusing of one or more tissue masses, and/or c) filling said cavity and/or space, said carrier optionally is or includes a foam.

2 . A method for forming a near net medical part or medical device comprising:
a. providing metal powder, said metal powder including two or more different types of metal powder; b. mixing together said metal powder to form at least a 99% uniform mixture of said metal powder; c. pressing said metal powder into a shape that is at least 80% the final shape of said medical part or medical device; d. sintering said metal powder while being maintained in said shape to bond together said metal powder to thereby form a firm and stable shaped part that is at least 80% the final shape of said medical part or medical device; and, e. cold working said firm and stable shaped part by subjecting said firm and stable shaped part to high pressure, said cold working increasing a mechanical strength of said firm and stable shaped part.

3 . The method as defined in claim 2 , wherein at least 90 wt. % of said metal powder includes two or more powders selected from the group of titanium powder, rhenium powder, molybdenum powder, tungsten powder, aluminum powder, copper powder, zirconium powder, niobium powder, iron powder, cobalt powder, nickel powder, manganese powder, vanadium powder, and chromium powder, said metal powder is optionally pressed together at a pressure of 10-300 tsi, and then the pressed powder is sintered at 1600-2600° C. to form said firm and stable shaped part that is at least 80% the final shape of said medical part or medical device, said high pressure during said cold working is optionally 10-300 tsi.

4 . The method as defined in claim 2 , wherein said metal powder constitutes a) at least 40 wt. % rhenium and at least 30 wt. % molybdenum and up to 5 wt. % one or more additional metals, b) at least 40 wt. % rhenium and at least 40 wt. % tungsten and up to 5 wt. % one or more additional metals, c) at least 70 wt. % molybdenum and at least 1 wt. % one or more of hafnium, carbon, yttrium, cesium, tungsten, tantalum, zinc, and/or lanthanum, or d) at least 40 wt. % titanium and at least 10 wt. % of aluminum, chromium, molybdenum and/or vanadium.

5 . A method for forming a near net medical part or medical device that has pre-defined cavities, surface channels, surface structures and/or passageways comprising:
a. providing metal powder and a polymer, said metal powder including one or more different types of metal powder; b. combine together said metal powder and said polymer; c. pressing said metal powder and said polymer into a shape that is at least 80% the final shape of said medical part or medical device; and, d. sintering said metal powder and said polymer while being maintained in said shape to bond together said metal powder to thereby form a firm and stable shaped part that is at least 80% the final shape of said medical part or medical device; wherein said step of sintering causes at least 5 vol. % of said polymer to degrade and be removed from said firm and stable shaped part to form said cavities, surface channels, surface structures and/or passageways in said cavities, surface channels, surface structures and/or passageways.

6 . The method as defined in claim 5 , wherein at least 0.5 vol. % of said polymer remains in said firm and stable shaped part after said step of sintering, said polymer optionally includes at least one antithrombogenic agent, steroid, thioprotese inhibitor, antimicrobial, antibiotic, tissue plasma activator, monoclonal antibody, antifibrosis compound, hormone, anti-mitotic agent, immunosuppressive agent, sense or antisense oligonucleotide, nucleic acid analogue, inhibitor of transcription factor activity, anti-neoplastic compound, chemotherapeutic compound, radioactive agent, growth factor, antiplatelet compound, antitabolite compound, anti-inflammatory compound, anticoagulent compound, antimitotic compound, antioxidant, antimetabolite compound, anti-migratory agent, anti-matrix compound, anti-vital compound, anti-proliferative, anti-fungal compound, anti-protozoal compound, anti-pain compound, human tissue, animal tissue, synthetic tissue, human cells, animal cells, synthetic cells, bone-stimulation matter, bone-growth matter, bone-activating matter or combinations thereof.

7 . The method as defined in claim 5 , wherein at least 90 wt. % of said metal powder includes two or more powders selected from the group of titanium powder, rhenium powder, molybdenum powder, tungsten powder, aluminum powder, copper powder, vanadium powder, and chromium powder.

8 . The method as defined in claim 5 , wherein said metal powder is pressed together at a pressure of 10-300 tsi, and then the pressed powder is sintered at 1600-2600° C. to form said firm and stable shaped part that is at least 90% the final shape of said medical part or medical device, said high pressure during said cold working is optionally 10-300 tsi.

9 . The method as defined in claim 5 , wherein said metal powder constitutes a) at least 40 wt. % rhenium and at least 30 wt. % molybdenum and up to 5 wt. % one or more additional metals, b) at least 40 wt. % rhenium and at least 40 wt. % tungsten and up to 5 wt. % one or more additional metals, c) at least 70 wt. % molybdenum and at least 1 wt. % one or more of hafnium, carbon, yttrium, cesium, tungsten, tantalum, zinc, and/or lanthanum, d) at least 40 wt. % titanium and at least 10 wt. % of aluminum, chromium, molybdenum and/or vanadium.

10 . A medical device that is at least partially formed of a TWIP alloy, wherein said TWIP alloy includes titanium and one or more of aluminum, molybdenum, chromium and vanadium.

11 . The medical device as defined in claim 10 , wherein said aluminum is 0.5-15 wt. %, said molybdenum is 0.5-15 wt. %, said vanadium is 0.5-15 wt. %, and said chromium is 0.1-12 wt. %.

12 . The medical device as defined in claim 10 , wherein said TWIP alloy includes 77-93 wt. % Ti, 2-6 wt. % Al, 2-6 wt. % Mo, 2-6 wt. % V, and 1-5 wt. % Cr.

13 . A medical device that is formed of a metal alloy that reduces the absorption, adhesion and/or proliferation of bacteria on the surface of the metal alloy, said metal alloy includes 40-60 wt. % molybdenum, and at least 5 wt. % of one or more secondary metals selected from the group of rhenium, titanium, tungsten, aluminum, copper, zirconium, niobium, iron, cobalt, nickel, manganese, vanadium, and chromium, said bacteria optionally includes Staphlococcus aureus and/or Staphlococcus epidermidis.

14 . The medical device as defined in claim 13 , wherein said medical device is a void filler, an adjunct to bone fracture stabilization, an intramedullary fixation device, a joint augmentation/replacement device, a bone fixation plate, a screw, a tack, a clip, a staple, a nail, a pin, a rod, an anchor, a scaffold, a stent, a mesh, a sponge, an implant for cell encapsulation, an implant for tissue engineering, a drug delivery device, a bone ingrowth induction catalyst, a monofilament, a multifilament structure, a sheet, a coating, a membrane, a foam, a screw augmentation device, a cranial reconstruction device, a heart valve, or a pacer lead.

15 . A medical device, comprising:
a substrate comprising a molybdenum-rhenium alloy and an oxide film that provide corrosi

Assignees

• Mirus Llc

Inventors

• Roth Noah

Classifications

• A61L27/56

  Porous materials, {e.g. foams or sponges} · CPC title

• C22C14/00

  Alloys based on titanium · CPC title

• A61L27/54

  Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} · CPC title

• B22F2301/205

  Titanium, zirconium or hafnium · CPC title

• C22C27/04

  Alloys based on tungsten or molybdenum · CPC title