Process and apparatus for making aligned or twisted electrospun fibers and devices

Patent metadata

Field	Value
Publication number	US-2019071796-A1
Application number	US-201716083774-A
Country	US
Kind code	A1
Filing date	Mar 13, 2017
Priority date	Mar 11, 2016
Publication date	Mar 7, 2019
Grant date	—

Abstract

A system for forming twisted or aligned electrospun fibers has been developed. The collector for the electrospun fibers is capable of rotation. In some instances, fibers are formed between two collectors, at least one of which rotates to twist the fibers into a multifilament bundle with increased strength. In a second embodiment, a cylindrical collector rotates, and charged polymer jet uniformly coats the surface of the collector. When a drum collector rotates at a high speed, electrospun fibers align and form an array. Optionally, different active agents can be included in the electrospinning solutions to form fiber constructs with different strengths and controlled release profiles, providing a reproducible method to generate complexed structures based on electrospun fibers and controlled drug delivery profiles.

First claim

1 . A system for forming aligned or twisted electrospun polymeric fibers comprising:
an electrically charged polymer solution, dispersion, gel, or melt, and one or more grounded collectors, wherein the electrically charged polymer solution forms polymeric fibers on the one or more grounded collectors, and wherein at least one of the collectors can be rotated to align or twist the polymeric fibers.

2 . The system of claim 1 , wherein the electrically charged polymer solution further comprises a therapeutic, prophylactic, or diagnostic agent.

3 . The system of claim 1 , wherein the polymer solution is extruded through one or more needles or nozzles to deposit on the one or more grounded collectors to form polymeric fibers.

4 . The system of claim 3 , wherein at least two grounded collectors are capable of rotation to twist polymeric fibers from both ends.

5 . The system of claim 3 , wherein the polymeric fibers are nanofibers, micro-fibers, or a combination thereof.

6 . The system of claim 1 , wherein the one or more grounded collectors comprise a cylindrical drum or rod, and the polymeric fibers form a mesh on the surface of the cylindrical drum.

7 . The system of claim 1 , wherein the one or more grounded collectors comprise a cylindrical drum or rod, and the polymeric fibers forms aligned fiber arrays.

8 . The system of claim 1 , wherein the one or more grounded collectors comprise a chuck and a stand-alone collector, and wherein the polymeric fibers have an end on the chuck or an attachment to the chuck capable of rotation and an end on the stand-alone collector.

9 . The system of claim 8 , wherein the chuck rotates to twist the polymeric fibers in a sufficient degree to increase tensile strength of the twisted polymeric fibers, compared to non-twisted or insufficiently twisted polymeric fibers.

10 . The system of claim 1 , wherein the one or more grounded collectors comprise a chuck, a stand-alone collector, and a thread between the chuck and the stand-alone collector, and wherein polymeric fibers coat the surface of the thread.

11 . The system of claim 10 , wherein the thread is connected to a needle to function as a suture.

12 . The system of claim 1 , wherein the one or more grounded collectors comprise a chuck, a stand-alone collector, and a template wire at least attached to the chuck, and wherein polymeric fibers forms a tubular device around the surface of the template wire.

13 . The system of claim 1 , wherein the one or more grounded collectors comprise a device to be coated with polymeric fibers.

14 . The system of claim 13 , wherein the device to be coated comprises a stent, a catheter, a blade, or a suture.

15 . A method of making aligned or twisted fibers, comprising:
extruding or spraying an electrically charged polymer solution, dispersion, gel, or melt toward one or more grounded collectors to form polymeric fibers, wherein at least one of the collectors are rotated to align or twist the polymeric fibers.

16 . The method of claim 15 , wherein the formed polymeric fibers coat the surface of a device connected to the one or more grounded collectors.

17 . The method of claim 16 , wherein the device comprises one or more threads or sutures.

18 . The method of claim 15 , wherein the polymeric fibers form a mat, mesh, suture, shunt, scaffold, or graft.

19 . A method of making a drug-loaded suture comprising:
twisting a plurality of polymeric fibers formed by extruding or spraying an electrically charged polymer solution, dispersion, gel, or melt comprising a therapeutic, prophylactic, or diagnostic agent in a system of claim 1 to form a multifilament thread.

20 . The method of claim 19 , wherein the multifilament thread comprises at least 1 wt % of the therapeutic, prophylactic, or diagnostic agent, and has a greater tensile strength than a non-twisted monofilament polymeric fiber of an identical composition.

21 . The method of claim 19 , wherein the electrically charged polymer solution, dispersion, gel, or melt comprises between about 8 wt % and about 80 wt % therapeutic, prophylactic, or diagnostic agent compared to the polymer amount.

22 . A polymeric fiber-based device prepared by the method of claim 15 , wherein the device comprises a mesh, a mat, a suture, a shunt, a stent, a graft, or a combination thereof.

Assignees

• Univ Johns Hopkins

Inventors

• Parikh Kunal S
• Patel Himat
• Hanes Justin

Classifications

• D01F1/103

  Agents inhibiting growth of microorganisms · CPC title

• D10B2509/04

  Sutures · CPC title

• D10B2331/04

  polyesters, e.g. polyethylene terephthalate [PET] · CPC title

• A61L17/005 Primary

  containing a biologically active substance, e.g. a medicament or a biocide · CPC title

• A61L17/105

  Polyesters not covered by A61L17/12 · CPC title