Mixed allergen compositions and methods for using the same

Patent metadata

Field	Value
Publication number	US-2019060445-A1
Application number	US-201816171887-A
Country	US
Kind code	A1
Filing date	Oct 26, 2018
Priority date	Feb 20, 2015
Publication date	Feb 28, 2019
Grant date	—

Abstract

Mixed allergen compositions of one, two or more different allergens are provided. In some instances, the mixed allergen compositions include: a nut allergen; an animal allergen; and at least one of: a non-nut plant allergen; a biotic agent; and a vitamin Also provided are methods of administering the mixed allergen compositions to a subject. The mixed allergen compositions find use in a variety of applications, including health maintenance, immune balance, gut balance, immune support, health improvement and therapeutic applications.

First claim

What is claimed is:

1 . A method for treating a food allergy in a subject suffering from multiple food allergies, the method comprising orally administering to the subject a mixed allergen composition comprising:
about 0.1% to about 15% by weight walnut complete allergen; about 0.1% to about 15% by weight peanut complete allergen; about 0.1% to about 15% by weight hazelnut complete allergen; about 0.1% to about 15% by weight soy complete allergen; and about 0.1% to about 15% by weight white fish complete allergen and/or pink fish complete allergen; wherein the weight is per total mass of the mixed allergen composition.

2 . The method of claim 1 , wherein the mixed allergen composition further comprises about 0.1% to about 15% by weight sesame complete allergen.

3 . The method of claim 1 , wherein the mixed allergen composition further comprises about 0.1% to about 15% by weight crustacean complete allergen.

4 . The method of claim 1 , wherein the mixed allergen composition comprises about 0.1% to about 15% by weight white fish complete allergen and about 0.1% to about 15% by weight pink fish complete allergen.

5 . The method of claim 1 , wherein the mixed allergen composition further comprises about 0.1% to about 15% by weight egg white complete allergen.

6 . The method of claim 1 , wherein the mixed allergen composition further comprises about 0.1% to about 15% by weight wheat complete allergen.

7 . The method of claim 1 , wherein the mixed allergen composition further comprises about 0.1% to about 15% by weight almond complete allergen.

8 . The method of claim 1 , wherein the mixed allergen composition further comprises about 0.1% to about 15% by weight oat complete allergen.

9 . The method of claim 1 , wherein the mixed allergen composition further comprises about 0.1% to about 15% by weight pecan complete allergen and/or about 0.1% to about 15% by weight pistachio complete allergen.

10 . A method for treating a food allergy in a subject in need thereof, the method comprising orally administering to the subject a mixed allergen composition comprising 2 to 20 different food protein allergens; wherein upon administration the food allergy is significantly inhibited in the subject as compared to administering a single food protein allergen.

11 . The method of claim 11 , wherein the mixed allergen composition comprises a peanut complete allergen and a tree nut complete allergen.

12 . A method for treating a food allergy in a subject suffering from one food allergy, the method comprising orally administering to the subject a mixed allergen composition comprising:
about 0.1% to about 15% by weight peanut complete allergen; about 0.1% to about 15% by weight tree nut complete allergen; and about 0.1% to about 15% by weight white fish complete allergen and/or pink fish complete allergen and/or crustacean complete allergen; wherein the weight is per total mass of the composition.

13 . The method of claim 12 , wherein the one food allergy is a peanut allergy.

14 . The method of claim 12 , wherein the one food allergy is a fish allergy.

15 . The method of claim 12 , wherein the one food allergy is a tree nut allergy.

16 . The method of claim 12 , wherein the mixed allergen composition further comprises about 0.1% to about 15% by weight walnut complete allergen and/or about 0.1% to about 15% by weight almond complete allergen and/or about 0.1% to about 15% by weight hazelnut complete allergen and/or about 0.1% to about 15% by weight cashew complete allergen and/or about 0.1% to about 15% by weight pecan complete allergen, wherein the weight is per total mass of the composition.

17 . The method of claim 12 , where the mixed allergen composition comprises about 0.1% to about 15% by weight white fish complete allergen and about 0.1% to about 15% by weight pink fish complete allergen.

18 . The method of claim 17 , wherein the mixed allergen composition comprises about 0.1% to about 15% by weight shrimp complete allergen.

Assignees

• Univ Leland Stanford Junior

Inventors

• Nadeau Kari C

Classifications

• A61K47/44

  Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin (synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14) · CPC title

• A61K2039/572

  cytotoxic response · CPC title

• A61K39/35 Primary

  Allergens · CPC title

• A61K2039/70

  Multivalent vaccine · CPC title

• A61K9/148

  with compounds of unknown constitution, e.g. material from plants or animals (with oils, fats, waxes, shellac A61K9/145) · CPC title