Concentration measuring module, dialyzer, and concentration calculating method

Patent metadata

Field	Value
Publication number	US-2019015573-A1
Application number	US-201816034569-A
Country	US
Kind code	A1
Filing date	Jul 13, 2018
Priority date	Jul 14, 2017
Publication date	Jan 17, 2019
Grant date	—

Abstract

The concentration measuring module includes a light source configured to emit light into a housing; a first light receiving unit configured to have sensitivity to a wavelength of output light of the light source and receive light radiated from inside the housing; and a second light receiving unit configured to have sensitivity to a longer wavelength than the first light receiving unit and receive light radiated from inside the housing. The light source, the first light receiving unit, and the second light receiving unit are arranged to have a positional relationship in which a light emitting surface of the light source faces a light receiving surface of the first light receiving unit, and a normal to a light receiving surface of the second light receiving unit is orthogonal to, of a line through the light source and the first light receiving unit, a line segment corresponding to the inside of the housing, and a length X of, of the line through the light source and the first light receiving unit, the line segment corresponding to the inside of the housing and then a length Y of, of a line including the normal to the light receiving surface of the second light receiving unit, a line segment corresponding to the inside of the housing satisfy Y/X>1. The concentration measuring module calculates the concentrations of two constituents simultaneously on the basis of first and second signals output from the first and second light receiving units.

First claim

What is claimed is:

1 . A concentration measuring module comprising:
a housing configured to be able to house an irradiated body; a light source configured to emit light into the housing; a first light receiving unit configured to have sensitivity to a wavelength of output light of the light source and receive light radiated from inside the housing; and a second light receiving unit configured to have sensitivity to a longer wavelength than the first light receiving unit and receive light radiated from inside the housing, wherein the light source and the first light receiving unit are arranged so that a light emitting surface of the light source faces a light receiving surface of the first light receiving unit, the light source, the first light receiving unit, and the second light receiving unit are arranged to have a positional relationship in which a normal to a light receiving surface of the second light receiving unit is orthogonal to a line segment corresponding to the inside of the housing, of a line through the light source and the first light receiving unit, and a length X of the line segment corresponding to the inside of the housing, of the line through the light source and the first light receiving unit and a length Y of a line segment corresponding to the inside of the housing, of a line including the normal to the light receiving surface of the second light receiving unit, satisfy Y/X>1.

2 . The concentration measuring module according to claim 1 , wherein the length X of the line segment and the length Y of the line segment satisfy 2√3<Y/X<50.

3 . The concentration measuring module according to claim 1 , wherein the length X of the line segment and the length Y of the line segment satisfy 1.4≤Y/(X̂0.2)≤20.

4 . The concentration measuring module according to claim 1 , wherein
the first light receiving unit receives light having been transmitted through the inside of the housing of the output light, and the second light receiving unit receives excitation light inside of the housing excited by the output light of the light source.

5 . The concentration measuring module according to claim 1 , wherein
the first light receiving unit has sensitivity to a wavelength of light attenuated by the irradiated body, of the output light, and the second light receiving unit has sensitivity to excitation light that the irradiated body excited by the output light radiates and has a longer wavelength than the output light.

6 . The concentration measuring module according to claim 1 , wherein the irradiated body contains two or more constituents.

7 . The concentration measuring module according to claim 1 , wherein a view volume P of the first light receiving unit with respect to the inside of the housing and a view volume Q of the second light receiving unit with respect to the inside of the housing satisfy 1≤Q/P≤200.

8 . The concentration measuring module according to claim 1 , wherein the normal to the light receiving surface of the second light receiving unit passes through a midpoint of, of the line through the light source and the first light receiving unit, the line segment corresponding to the inside of the housing.

9 . The concentration measuring module according to claim 1 , wherein the length X of the line segment satisfies 1 mm≤X≤10 mm.

10 . The concentration measuring module according to claim 1 , wherein the length X of the line segment satisfies 2 mm≤X≤5 mm.

11 . The concentration measuring module according to claim 1 , wherein a shape of the housing is a rectangular shape in a cross-sectional view of the housing along a plane including the light source, the first light receiving unit, and the second light receiving unit.

12 . The concentration measuring module according to claim 1 , wherein
the second light receiving unit has an amplifier circuit on an output side of the second light receiving unit, the amplifier circuit being configured to amplify an output of the second light receiving unit, and a distance in a straight line between the center of a photoreceptor of the second light receiving unit and a contact point of a wiring on the first amplifier circuit is 5 cm or less, the wiring connecting the photoreceptor with the first amplifier circuit.

13 . The concentration measuring module according to claim 1 , wherein
the second light receiving unit has an amplifier circuit on an output side of the second light receiving unit, the amplifier circuit being configured to amplify an output of the second light receiving unit, and 90% or more of a solid angle viewed from a center of a wiring from a photoreceptor of the second light receiving unit to the amplifier circuit is covered with a good conductor.

14 . The concentration measuring module according to claim 1 , wherein
the second light receiving unit has an amplifier circuit on an output side of the second light receiving unit, the amplifier circuit being configured to amplify an output of the second light receiving unit, and 90% or more of a solid angle viewed from the center of a wiring from a photoreceptor of the second light receiving unit to the amplifier circuit is covered with a good conductor, and the amplifier circuit is electrically shielded by the good conductor.

15 . The concentration measuring module according to claim 1 , wherein the irradiated body contains urea and albumin.

16 . The concentration measuring module according to claim 15 , wherein
the first light receiving unit is configured to have sensitivity to a wavelength of light attenuated by urea contained in the irradiated body, of the output light, and the second light receiving unit is configured to have sensitivity to a wavelength of excitation light that albumin contained in the irradiated body radiates by the output light.

17 . The concentration measuring module according to claim 1 , wherein the light source is a light-emitting diode configured to emit light with a wavelength band of 200 nm or more and 300 nm or less.

18 . The concentration measuring module according to claim 1 , further comprising an arithmetic logical unit configured to calculate concentration of a constituent contained in the irradiated body on a basis of outputs of the first and second light receiving units.

19 . The concentration measuring module according to claim 1 , further comprising a control unit configured to control driving of the light source.

20 . The concentration measuring module according to claim 19 , wherein the control unit drives the light source so that the output light is emission pulses with a duty ratio of 20% or less.

21 . A dialyzer comprising the concentration measuring module according to claim 1 .

22 . A method of calculating concentrations of two constituents contained in an irradiated body irradiated with output light of a light source by using the concentration measuring module according to claim 1 , the method comprising:
acquiring a first signal correlated to an amount of absorption of the output light by the irradiated body; acquiring a second signal correlated to an amount of excitation of the irradiated body by the output light, the second signal being different from the first signal; and calculating the concentrations of the two constituents on a basis of the first and second signals.

Assignees

• Asahi Chemical Ind

Inventors

• Sugiyama Sho
• Miya Shinji
• Yamaha Yoshiro

Classifications

• A61M2202/0498

  Urea · CPC title

• A61M1/1609 Primary

  after use, i.e. downstream of dialyser · CPC title

• A61M2205/15

  Detection of leaks · CPC title

• A61M1/1619

  Sampled collection of used dialysate, i.e. obviating the need for recovery of whole dialysate quantity for post-dialysis analysis · CPC title

• A61B5/6887

  mounted on external non-worn devices, e.g. non-medical devices · CPC title