Cocoa polyphenols and soluble dietary fiber for use in the treatment or prevention disorders associated with an above-normal number of granulocytes in a tissue

Patent metadata

Field	Value
Publication number	US-2019008824-A1
Application number	US-201615780490-A
Country	US
Kind code	A1
Filing date	Dec 1, 2016
Priority date	Dec 4, 2015
Publication date	Jan 10, 2019
Grant date	—

Abstract

The present invention relates to a composition comprising at least one cocoa polyphenol and soluble dietary fiber for use in the prevention or treatment of a disorder associated with an above-normal number of granulocytes in a tissue.

First claim

1 . A method for the prevention or treatment of a disorder associated with an above-normal number of granulocytes in a tissue comprising administering a composition comprising at least one cocoa polyphenol and at least one fermentable dietary fiber to an individual in need of same.

2 . Method according to claim 1 , wherein the disorder associated with an above-normal number of granulocytes in a tissue is selected from the group consisting of an eosinophilic gastrointestinal disorder, an allergy, a gastrointestinal syndrome, allergy associated with aeroallergen including asthma and allergic rhinithis, lung allergic inflammation and skin atopic dermatitis.

3 - 4 . (canceled)

5 . Method according to claim 1 , wherein the soluble dietary fiber is selected from the group consisting of pectin, beta-glucan, inulin, fructo- or galacto-oligosaccharides, pectin, alginic acids, fructans like inulin, raffinose, xylose, polydextrose, lactulose, Acacia gum, Guar Gum milk-derived oligosaccharides, and hydrolyzed fiber.

6 . Method according to claim 1 , wherein the composition comprises 2 to 80% (w/w) fermentable dietary fiber.

7 . Method according to claim 1 , further comprising a source of protein.

8 . Method according to claim 7 , wherein the protein is selected from the group consisting of potato protein, rice protein, legumes proteins, millet, quinoa, lupin, canola, tapioca, and combinations thereof.

9 . (canceled)

10 . Method according to claim 1 comprising a procyanidin selected from the group consisting of procyanidin B 1, procyanidin B2, a procyanidin not being procyanidin B1 or B2, one or more multimers of procyanidin B 1, procyanidin B2 or the procyanidins not being B1 or B2, the multimer being any of a 2-mer to a 10-mer; combinations thereof.

11 . Method according to claim 1 , wherein the composition comprises 0.01% to 0.5% (w/w) procyanidin B1 or multimers of the procyanidin.

12 . Method according to claim 1 , wherein the composition comprises 0.01% to 1.0% (w/w) procyanidin B2 or multimers of the procyanidin.

13 . Method according to claim 1 , wherein the composition comprises 0.5% to 10% (w/w) of procyanidins not being either procyanidin B1 or B2 or multimers of the procyanidins.

14 . Method according to claim 1 , wherein the composition comprises 0.01% to 0.5% (w/w) epicathequin.

15 . Method according to claim 1 , wherein the cocoa polyphenols are comprised in a plant extract or a concentrate.

16 . Method according to claim 1 , wherein the composition is to be administered orally, topical-orally, or in the form of a spray.

17 . Method according to claim 1 , wherein the composition is to be administered to a human being or a pet animal.

18 . (canceled)

19 . Method according to claim 1 , wherein the composition is in a form selected from the group consisting of a nutritional composition, an oral nutritional supplement provided as sole source of nutrition or as partial nutrition, complete or incomplete nutrition and a pharmaceutical product.

20 . Method according to claim 1 , having a caloric density of 0.5-3.0 kcal/ml.

21 . Method according to claim 1 comprising 10-40 en % protein, 10-60 en % carbohydrates, and 20-80 en % fat.

22 . Method according to claim 1 , wherein the fat is selected from the group consisting of fish oil, vegetable oil, medium chain triglycerides and mixtures thereof.

23 . Method according to claim 1 , wherein the composition comprises fat and 0-70 wt. %, of the fat are medium chain triglycerides.

24 . Method according to claim 1 , wherein the composition comprises carbohydrates and the carbohydrates are selected from a source selected from the group consisting of maltodextrin, starch, lactose, modified carbohydrates, sugar alcohols, high potency sweeteners and combinations thereof.

25 - 26 . (canceled)

Assignees

• Nestec Sa

Inventors

• Blanchard Carine
• Holvoet Sebastien
• Ran-Ressler Rinat
• Kuslys Martinas

Classifications

• A61K31/353 Primary

  3,4-Dihydrobenzopyrans, e.g. chroman, catechin · CPC title

• A61K36/5777

  Theobroma, e.g. cocao or cocoa · CPC title

• A23L33/21

  Addition of substantially indigestible substances, e.g. dietary fibres · CPC title

• A61K36/185

  Magnoliopsida (dicotyledons) · CPC title

• A61K9/006

  Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays · CPC title