Biodegradable Poly(Ester Amide) Elastomers and Uses Therefor

Patent metadata

Field	Value
Publication number	US-2018369448-A1
Application number	US-201815995660-A
Country	US
Kind code	A1
Filing date	Jun 1, 2018
Priority date	Aug 3, 2015
Publication date	Dec 27, 2018
Grant date	—

Abstract

Provided herein are biodegradable poly(ester amide) elastomers, methods of making the elastomers, and methods of using the elastomers, for example for tissue engineering. The elastomers can be used for preparation of tissue prostheses, such as a heart valve leaflet, a heart valve, cartilage, myocardium, blood vessels, smooth muscle, skeletal muscle, or other tissues. Also provided herein are semiquantitative FTIR methods for determining structure of a poly(ester amide) elastomer.

First claim

1 .- 20 . (canceled)

21 . A biocompatible scaffold for treating a wound or defect in a patient, comprising a substrate and a polymer composition, wherein the polymer composition comprises a copolymer comprising residues of polyethylene glycol, glycerol, sebacic acid, and 1-3-diamino-2-hydroxy-propane.

22 . The scaffold of claim 21 , wherein the substrate is a woven material, a non-woven material, a mesh, a suture, a stent, an aneurysm coil, a metallic implant, a polymeric implant, a ceramic implant, an ECM composition, a composite with synthetic or natural ECM material, or a suitable substrate thereof.

23 . The scaffold of claim 21 , wherein the substrate is a sheet, thread, powder, tube, an aligned/anisotropic or isotropic fibrous structure.

24 . The scaffold of claim 21 , wherein the substrate is a polyester elastomer.

25 . The scaffold of claim 24 , wherein the polyester elastomer is polycaprolactone.

26 . The scaffold of claim 21 , wherein the substrate and polymer composition are anisotropically electrospun.

27 . The scaffold of claim 21 , further comprising an active agent.

28 . The scaffold of claim 27 , wherein the active agent is an antioxidant.

29 . The scaffold of claim 28 , wherein the active agent is a cerium nanoparticle.

30 . An anisotropic heart valve leaflet, comprising a substrate and a polymer composition, wherein the polymer composition comprises a copolymer comprising residues of polyethylene glycol, glycerol, sebacic acid, and 1-3-diamino-2-hydroxy-propane.

31 . The heart valve leaflet of claim 30 , wherein the substrate is a woven material, a non-woven material, a mesh, a suture, a stent, an aneurysm coil, a metallic implant, a polymeric implant, a ceramic implant, an ECM composition, a composite with synthetic or natural ECM material, or a suitable substrate thereof.

32 . The heart valve leaflet of claim 30 , wherein the substrate is a sheet, thread, powder, tube, an aligned/anisotropic or isotropic fibrous structure.

33 . The heart valve leaflet of claim 30 , wherein the substrate is a polyester elastomer.

34 . The heart valve leaflet of claim 33 , wherein the polyester elastomer is polycaprolactone.

35 . The heart valve leaflet of claim 30 , wherein the substrate and polymer composition are anisotropically electrospun.

36 . The heart valve leaflet of claim 30 , further comprising an active agent.

37 . The heart valve leaflet of claim 36 , wherein the active agent is an antioxidant.

38 . The heart valve leaflet of claim 37 , wherein the active agent is a cerium nanoparticle.

Assignees

• Univ Pittsburgh Commonwealth Sys Higher Education

Inventors

• Sant Shilpa
• Sant Vinayak

Classifications

• A61L2300/624

  Nanocapsules · CPC title

• C08G69/48

  Polymers modified by chemical after-treatment · CPC title

• A61L2300/102

  Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates · CPC title

• C12N2533/30

  Synthetic polymers · CPC title

• C08G2230/00

  Compositions for preparing biodegradable polymers · CPC title