Dispensing apparatus

Patent metadata

Field	Value
Publication number	US-2018348247-A1
Application number	US-201815865044-A
Country	US
Kind code	A1
Filing date	Jan 8, 2018
Priority date	Jun 1, 2017
Publication date	Dec 6, 2018
Grant date	—

Abstract

The objective of this disclosure is to provide a dispensing apparatus that is capable of precisely dispense micro volume liquid samples without physically damaging the nozzle tip or the liquid containers. An example of the present disclosure images a droplet of a liquid sample, and dispenses the liquid sample using an image of the droplet.

First claim

What is claimed is:

1 . A dispensing apparatus that dispenses a liquid sample to a component holding the sample, comprising:
a nozzle that discharges the sample; an imager that images a droplet of the sample discharged to the component; and a dispensing mechanism that dispenses the sample using an image of the droplet imaged by the imager.

2 . The dispensing apparatus according to claim 1 , further comprising a processor that controls a behavior of the dispensing apparatus,
wherein the processor measures a size of the droplet using an image of the droplet imaged by the imager, and wherein the processor calculates a first distance using a size of the droplet when the droplet is separated from a tip of the nozzle, the first distance being a distance between the tip of the nozzle and a dispense target surface to which the droplet is dispensed.

3 . The dispensing apparatus according to claim 2 ,
wherein the dispensing mechanism comprises a mechanism that moves the nozzle in a horizontal direction and in a vertical direction according to an instruction from the processor, and wherein the processor moves the nozzle in the horizontal direction, and discharges the sample after moving the nozzle in the vertical direction using the first distance, thereby limiting, within a predetermined range, an error of liquid volume of the sample dispensed by the nozzle to the component.

4 . The dispensing apparatus according to claim 3 , further comprising a storage unit that stores data describing a relationship between a size of the droplet when the droplet is separated from the tip of the nozzle and the first distance,
wherein the processor refers to the data using the size of the droplet, thereby acquiring the first distance corresponding to the size of the droplet, and wherein the processor moves the nozzle in the vertical direction using the acquired first distance.

5 . The dispensing apparatus according to claim 3 ,
wherein the processor raises the nozzle by a second distance after the nozzle discharges the sample, the second distance being a distance calculated by adding a predetermined micro distance to the first distance, wherein the processor moves the nozzle in the horizontal direction to a next dispense position after raising the nozzle by the second distance, and wherein the processor causes the nozzle to discharge the sample at the next dispense position after lowering the nozzle by the second distance.

6 . The dispensing apparatus according to claim 4 ,
wherein the data describes the relationship for each combination of a type of the sample, a liquid volume by which the nozzle discharges the sample, an inner diameter of the nozzle, and a thickness of the nozzle, and wherein the processor acquires the first distance corresponding to the combination by referring to the data using a type of the sample, a liquid volume by which the nozzle discharges the sample, an inner diameter of the nozzle, and a thickness of the nozzle.

7 . The dispensing apparatus according to claim 2 ,
wherein the imager images a variation of size of the droplet while the nozzle is discharging the sample, and wherein the processor calculates a viscosity parameter that indicates an intensity of viscosity of the sample according to a temporal variation ratio of size of the droplet imaged by the imager.

8 . The dispensing apparatus according to claim 7 ,
wherein the larger the viscosity of the sample is, the slower the processor sets a speed at which the nozzle is raised after discharging the sample.

9 . The dispensing apparatus according to claim 8 , further comprising a storage unit that stores a data table describing a relationship between the viscosity parameter and a speed at which the nozzle is raised, and
wherein the processor refers to the data table using a variation ratio of the size of the droplet, thereby acquiring the speed corresponding to the variation ratio, and raises the nozzle at the acquired speed.

10 . The dispensing apparatus according to claim 2 ,
wherein the processor determines whether the sample has contacted with the component according to the size of the droplet imaged by the imager, and wherein the processor lowers the nozzle by a predetermined amount if the sample has not contacted with the component.

11 . The dispensing apparatus according to claim 4 ,
wherein the data describes the relationship for each of material of the component, and wherein the processor refers to the data specifying a material of the component, thereby acquiring the first distance corresponding to a material of the component.

12 . The dispensing apparatus according to claim 1 ,
wherein the nozzle and the imager are arranged to sandwich the component, wherein the nozzle dispenses the sample so that the sample contacts with one surface of the component, and wherein the imager images the sample from another surface of the component.

Assignees

• Hitachi Ltd
• Hitachi Ltd

Inventors

• Ando Takahiro

Classifications

• B01L2200/0605

  Metering of fluids · CPC title

• B01L2200/14

  Process control and prevention of errors · CPC title

• B01L3/0244

  using pins · CPC title

• G01N35/1011 Primary

  Control of the position or alignment of the transfer device · CPC title

• G01N2035/1013

  Confirming presence of tip · CPC title