Single channel, multiple drug delivery device and methods

Patent metadata

Field	Value
Publication number	US-2018338904-A1
Application number	US-201815996349-A
Country	US
Kind code	A1
Filing date	Jun 1, 2018
Priority date	Sep 27, 2012
Publication date	Nov 29, 2018
Grant date	—

Abstract

Devices and methods are provided for drug delivery. The device may include a housing configured for intralumenal deployment into a human or animal subject and a reservoir contained within the housing and having an actuation end and a release end. The release end may include at least one outlet. A first drug formulation and a second drug formulation may be disposed within the reservoir and adjacent to each other and immiscible, or separated from each other by a first barrier. The device may also include a plug within the reservoir at the actuation end, the plug being movable toward the release end to drive the first and second drug formulations out of the reservoir. The device may also include an actuation system operably connected to the actuation end of the reservoir and configured to drive the plug toward the release end and release the drug formulations from the reservoir.

First claim

1 - 15 . (canceled)

16 . A device for drug delivery comprising:
a housing configured for intraluminal deployment into a human or animal subject; a reservoir contained within the housing and having an actuation end and a release end, the release end comprising at least one outlet; a first drug formulation disposed within the reservoir; a second drug formulation disposed within the reservoir and separated from the first drug formulation by a first barrier; a plug at the actuation end within the reservoir, the plug being movable toward the release end to drive the first and second drug formulations out of the reservoir; an actuation system operably connected to the actuation end of the reservoir and configured to drive the plug toward the release end such that the first drug formulation is released from the reservoir before the second drug formulation is released from the reservoir; and a barrier retention chamber connected to the release end of the reservoir and configured to receive and retain the first barrier before the release of the second drug formulation.

17 . The device of claim 16 , wherein the first barrier comprises an inert gel.

18 . The device of claim 16 , wherein the first barrier comprises a solid barrier.

19 . The device of claim 16 , wherein the reservoir is defined by an inner surface of an elongated annular tube.

20 . The device of claim 16 , wherein the release end of the reservoir comprises a ring of outlets.

21 . The device of claim 16 , wherein the housing comprises a porous membrane sidewall in fluid communication with the at least one outlet of the release end of the reservoir, the porous membrane sidewall being configured to control diffusion of the first and second drug formulations released from the reservoir.

22 . The device of claim 21 , wherein the porous membrane sidewall comprises a polypropylene membrane.

23 . The device of claim 21 , wherein the porous sidewall membrane has a pore size from about 0.2 μm to about 25 μm.

24 . The device of claim 16 , wherein the barrier retention chamber comprises a hydrophobic vent

25 - 31 . (canceled)

Assignees

• Inguran Llc

Inventors

• Uhland Scott A
• Abhishek Ramkumar
• Peeters Eric
• Curley Timothy J

Classifications

• A61K9/0004 Primary

  Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas · CPC title

• A61M31/002

  Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time (artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50) · CPC title

• A61K9/0034

  Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants · CPC title