Nasal delivery

Patent metadata

Field	Value
Publication number	US-2018311450-A1
Application number	US-201815924536-A
Country	US
Kind code	A1
Filing date	Mar 19, 2018
Priority date	Mar 23, 2006
Publication date	Nov 1, 2018
Grant date	—

Abstract

A delivery device for and method of delivering a dose of substance for systemic uptake to a nasal cavity of a subject, the delivery device comprising: a nosepiece unit for insertion into a nasal cavity of a subject and comprising an outlet unit which includes at least one nozzle for delivering substance for systemic uptake substantially only to surfaces in one or both of the anterior region and an anterior section of the posterior region of the nasal cavity of the subject; and a substance supply unit which is operable so deliver a dose of substance to the at least one nozzle.

First claim

1 - 78 . (canceled)

79 . A delivery device for delivering a substance to a nasal cavity of a subject for systemic uptake, the delivery device comprising:
a nosepiece for insertion into the nasal cavity of the subject, the nosepiece including an outlet unit comprising:
a first nozzle; and
a posterior nosepiece member configured to obstruct the nasal cavity and partition the nasal cavity into anterior and posterior regions such that substantially all of the substance is delivered from the first nozzle to the anterior region;
a mouthpiece in fluid communication with the nosepiece through which the subject exhales to deliver an exhalation air flow to the posterior region of the nasal cavity and to cause closure of an oropharyngeal velum of the subject; and a substance supply unit operable to deliver the substance to the first nozzle.

80 . The delivery device of claim 79 , wherein the substance supply unit is breath actuated on oral exhalation by the subject.

81 . The delivery device of claim 79 , wherein the substance supply unit is breath actuated on nasal exhalation by the subject.

82 . The delivery device of claim 79 , wherein the substance supply unit is manually actuated.

83 . The delivery device of claim 79 , wherein the outlet unit further comprises a second nozzle.

84 . The delivery device of claim 79 , wherein the first nozzle is substantially laterally directed so as to direct the substance to a lateral surface within the anterior region of the nasal cavity.

85 . The delivery device of claim 79 , wherein the first nozzle is configured to deliver a liquid.

86 . The delivery device of claim 79 , wherein the first nozzle is configured to deliver a powder.

87 . The delivery device of claim 79 , wherein the posterior region comprises the region of the nasal cavity posterior of the nasal valve.

88 . The delivery device of claim 79 , wherein the posterior nosepiece member is configured to close the nasal valve of the subject.

89 . A method of delivering a substance to a nasal cavity of a subject for systemic uptake, the method comprising:
inserting a nosepiece into the nasal cavity of the subject, the nosepiece including an outlet unit having a first nozzle, a posterior nosepiece member configured to obstruct the nasal cavity and partition the nasal cavity into anterior and posterior regions such that substantially all of the substance is delivered from the first nozzle to the anterior region; inserting a mouthpiece into the mouth of the subject through which the subject exhales to deliver an exhalation air flow to the posterior region of the nasal cavity and to cause closure of an oropharyngeal velum of the subject; and delivering the substance from a substance supply unit to the first nozzle.

90 . The method of claim 89 , wherein the first nozzle is substantially laterally directed so as to direct the substance to a lateral surface within the anterior region of the nasal cavity.

91 . The method of claim 89 , wherein the first nozzle is configured to deliver a liquid.

92 . The method of claim 89 , wherein the first nozzle is configured to deliver a powder.

93 . The method of claim 89 , further comprising the step of delivering the substance through the first nozzle to the anterior region of the nasal cavity of the subject.

94 . The method of claim 89 , wherein the posterior region comprises the region of the nasal cavity posterior of the nasal valve.

95 . The method of claim 89 , wherein the posterior nosepiece member is configured to close the nasal valve of the subject.

Assignees

• Optinose As

Inventors

• Djupesland Per Gisle

Classifications

• A61M15/0003

  with means for dispensing more than one drug · CPC title

• A61M15/0098

  Activated by exhalation · CPC title

• A61M15/08 Primary

  Inhaling devices inserted into the nose · CPC title

• A61M15/009

  using medicine packages with incorporated spraying means, e.g. aerosol cans (pocket atomiser of the injector type A61M11/08) · CPC title

• A61M15/0065

  Inhalators with dosage or measuring devices (A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52) · CPC title