System and method for remote detection and modulation of electrical states in living tissues using magnetic particles and liquid crystals

Patent metadata

Field	Value
Publication number	US-2018310858-A1
Application number	US-201815964289-A
Country	US
Kind code	A1
Filing date	Apr 27, 2018
Priority date	Apr 27, 2017
Publication date	Nov 1, 2018
Grant date	—

Abstract

Disclosed embodiments are directed to a method and system for remotely imaging electric fields from living tissues.

First claim

We claim:

1 . A system comprising:
at least one untethered device component for introduction into living tissue of a subject; and a controller coupled to equipment for remotely sensing a magnetic field produced by the at least one untethered device component introduced in living tissue of a subject in response to one or more electric fields produced by the living tissue, wherein the device component is no larger than 100 microns in any single dimension, wherein the device component contains at least one magnetic particle in a liquid crystal solution, wherein the liquid crystal is sensitive to one or more electric fields produced by the living tissue, and wherein the equipment for remotely sensing the configuration of the at least one magnetic particle provides data that enables the system to characterize the electrical status of the living tissue in which the at least one untethered device component is located.

2 . The system of claim 1 , wherein the untethered device component is positioned within the subject under the influence of magnetic fields produced at least in part by the controller.

3 . The system of claim 1 , wherein one or more sections of the at least one device component are coated with a biocompatible material.

4 . The system of claim 1 , wherein one or more sections of the at least one device component are coated with a material to enhance transport to or through living tissue.

5 . The system of claim 1 , wherein one or more sections of the at least one device component are coated with a material to enhance transport through a barrier between blood and brain.

6 . The system of claim 1 , wherein the at least one device may be moved or deformed under the influence of magnetic fields produced at least in part by the controller in order to affect the living tissue.

7 . The system of claim 1 , wherein the at least one device may affect the electrical properties of nearby neurons under the influence of magnetic fields produced at least in part by the controller in order to affect the living tissue.

8 . A method comprising:
introducing at least one untethered device component into a living tissue of a subject; positioning the at least one untethered device component in the living tissue of the subject under control of controller; applying one or more electric fields produced under control of the controller to the at least one untethered device component in the living tissue of the subject; and remotely sensing a magnetic field produced by the at least one untethered device component positioned in the living tissue of the subject in response to the one or more electric fields produced by the living tissue, wherein the device component is no larger than 100 microns in any single dimension, wherein the device component contains at least one magnetic particle in a liquid crystal solution, wherein the liquid crystal is sensitive to the one or more electric fields produced by the living tissue, and wherein equipment for remotely sensing the magnetic field provides data that enables the system to characterize the living tissue in which the at least one untethered device component is positioned.

9 . The method of claim 8 , wherein one or more sections of the at least one device component are coated with a biocompatible material.

10 . The method of claim 8 , wherein one or more sections of the at least one device component are coated with a material to enhance transport to or through living tissue.

11 . The method of claim 8 , wherein one or more sections of the at least one device component are coated with a material to enhance transport through a barrier between blood and brain.

12 . The method of claim 8 , wherein the at least one device may be moved or deformed under the influence of magnetic fields produced at least in part by the controller in order to affect the living tissue.

13 . The method of claim 8 , wherein the at least one device may affect the electrical properties of nearby neurons under the influence of magnetic fields produced at least in part by the controller in order to affect the living tissue.

14 . A system comprising:
at least one untethered device component for introduction into living tissue of a subject; and a controller coupled to equipment for remotely sensing a magnetic field produced by the at least one untethered device component introduced in living tissue of a subject in response to one or more electric fields produced by the living tissue, wherein the device component is no larger than 100 microns in any single dimension, wherein the device component contains at least one magnetic particle in a liquid crystal solution, wherein the at least one device affects the electrical properties of at least one nearby neuron under the influence of one or more magnetic fields produced at least in part by the controller.

15 . The system of claim 14 , wherein the untethered device component is positioned within the subject under the influence of magnetic fields produced at least in part by the controller.

16 . The system of claim 14 , wherein one or more sections of the at least one device component are coated with a biocompatible material.

17 . The system of claim 14 , wherein one or more sections of the at least one device component are coated with a material to enhance transport to or through living tissue.

18 . The system of claim 14 , wherein one or more sections of the at least one device component are coated with a material to enhance transport through a barrier between blood and brain.

19 . A method comprising:
introducing at least one untethered device component into a living tissue of a subject; positioning the at least one untethered device component in the living tissue of the subject under control of controller; applying one or more electric fields produced under control of the controller to the at least one untethered device component in the living tissue of the subject; and remotely sensing a magnetic field produced by the at least one untethered device component positioned in the living tissue of the subject in response to the one or more electric fields produced by the living tissue, wherein the device component is no larger than 100 microns in any single dimension, wherein the device component contains at least one magnetic particle in a liquid crystal solution, wherein the at least one device affects the electrical properties of at least one nearby neuron under the influence of one or more magnetic fields produced at least in part by the controller.

20 . The method of claim 19 , wherein one or more sections of the at least one device component are coated with a biocompatible material.

21 . The method of claim 19 , wherein one or more sections of the at least one device component are coated with a material to enhance transport to or through living tissue.

22 . The method of claim 19 , wherein one or more sections of the at least one device component are coated with a material to enhance transport through a barrier between blood and brain.

Assignees

• Weinberg Medical Physics Inc

Inventors

• Weinberg Irving N
• Mair Lamar Odell
• Smela Elisabeth
• Martinez-Miranda Luz
• Nacev Aleksandar Nelson

Classifications

• A61B5/24

  Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof · CPC title

• A61B5/055 Primary

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title

• G01R33/381

  using electromagnets · CPC title

• G01R33/56

  Image enhancement or correction, e.g. subtraction or averaging techniques {, e.g. improvement of signal-to-noise ratio and resolution} · CPC title

• A61K49/1824

  coated or functionalised nanoparticles (liposomes A61K49/1812; nanoemulsions A61K49/1806; micelles A61K49/1809) · CPC title