Highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester with reduced environmental pollutants, and method for producing same

Patent metadata

Field	Value
Publication number	US-2018305291-A1
Application number	US-201816019992-A
Country	US
Kind code	A1
Filing date	Jun 27, 2018
Priority date	May 14, 2012
Publication date	Oct 25, 2018
Grant date	—

Abstract

A highly unsaturated fatty acid or a highly unsaturated fatty acid ethyl ester that has been produced using as a feedstock oil a fat or oil that contains highly unsaturated fatty acids as constituent fatty acids and which has been reduced in the contents of environmental pollutants, wherein among the dioxins contained, polychlorinated dibenzoparadioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are contained in amounts of less than 0.05 pg-TEQ/g and coplanar PCBs (Co-PCBs) in amounts of less than 0.03 pg-TEQ/g. Also disclosed is a method for producing the highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester by the steps of removing free fatty acids and environmental pollutants by thin-film distillation from a feedstock oil, ethyl esterifying the resulting fat or oil, and refining the same by rectification and column chromatography.

First claim

1 - 20 . (canceled)

21 . A composition comprising a highly unsaturated fatty acid or a highly unsaturated fatty acid ethyl ester which has been produced using as a feedstock oil or fat that contains (i) the highly unsaturated fatty acid as a constituent fatty acid, and (ii) a brominated flame retardant,
wherein the composition comprises a brominated flame retardant, and wherein the amount of the brominated flame retardant has been reduced to such a level that the amount of BDE-47 is less than 0.18 ng/g, the amount of BDE-100 is less than 0.03 ng/g, the amount of BDE-49 is less than 0.05 ng/g, or the amount of BDE-99 is less than 0.05 ng/g.

22 . The composition according to claim 21 , wherein the concentration of highly unsaturated fatty acids in the sum of fatty acids is at least 80 area %, at least 85 area %, at least 90 area %, at least 95 area %, or at least 96 area %.

23 . The composition according to claim 21 , wherein the fat or oil is fish oil, krill oil, marine mammal oil, or microorganism oil.

24 . The composition according to claim 21 , wherein the highly unsaturated fatty acid is any one of eicosapentaenoic acid, docosahexaenoic acid, docosapentaenoic acid, dihomo-γ-linoleic acid and arachidonic acid or a combination thereof.

25 . A medicine, supplement, food, cosmetics, or feeds which comprises the composition according to claim 21 as an active ingredient.

Assignees

• Nippon Suisan Kaisha Ltd

Inventors

• Doisaki Nobushige
• Hata Kazuhiko
• Tokiwa Shinji
• Matsushima Kazunori

Classifications

• A61P3/02

  Nutrients, e.g. vitamins, minerals · CPC title

• A61K35/66

  Microorganisms or materials therefrom (fungi, yeasts or candida A61K36/06) · CPC title

• C07C67/56

  by solid-liquid treatment; by chemisorption · CPC title

• A23L33/115

  Fatty acids or derivatives thereof; Fats or oils · CPC title

• A61K31/232

  having three or more double bonds, e.g. etretinate · CPC title