Administration of drugs to a patient

Patent metadata

Field	Value
Publication number	US-2018296814-A1
Application number	US-201815995890-A
Country	US
Kind code	A1
Filing date	Jun 1, 2018
Priority date	Aug 17, 2010
Publication date	Oct 18, 2018
Grant date	—

Abstract

The invention relates to a method and an electronic pill ( 20 ) for administration of at least one drug ( 3 ) to a patient, wherein a delivery profile of the at least one drug is determined according to at least one individual parameter of the patient. The at least one individual parameter may particularly relate to a genotype (GEN) or phenotype of the patient and for example comprise a distribution of proteins in the patient's gastrointestinal tract (GIT). Optionally, the individual parameter may be adjusted based on measurements by the electronic pill or external devices during its passage through the patient's gastrointestinal tract.

First claim

1 . (canceled)

2 . An electronic pill, comprising:
a drug reservoir; and a controller configured to control delivery of a drug from the drug reservoir to a patient with a delivery profile that is based on at least one parameter of the patient, wherein the at least one parameter comprises at least one member selected from the group consisting of:
pharmacokinetic data based on at least one member selected from the group consisting of blood of the patient, urine of the patient, and pharmacokinetic data based on breath of the patient;
a response of the patient to administration of the drug; and
a profile of co-administered drugs; and
wherein the delivery profile comprises:
a composition of the drug to be delivered;
an amount of drug to be delivered and/or a rate delivery of the drug to be delivered; and
a location in the gastrointestinal tract of the patient where the drug is to be delivered.

3 . The electronic pill of claim 2 , wherein the at least one parameter relates to an expected response of the patient to administration of the drug.

4 . The electronic pill of claim 3 , wherein the expected response of the patient to administration of the drug relates to metabolism of the administered drug by the patient.

5 . The electronic pill of claim 3 , wherein the expected response of the patient to administration of the drug relates to absorption of the administered drug by the patient.

6 . The electronic pill of claim 3 , wherein the expected response of the patient to administration of the drug relates to efflux of the administered drug by the patient.

7 . The electronic pill of claim 3 , wherein the expected response of the patient to administration of the drug relates to a genotype that predicts response to a drug.

8 . The electronic pill of claim 7 , wherein the delivery profile comprises a composition of the drug to be delivered based on the genotype that predicts response to the drug comprises.

9 . The electronic pill of claim 8 , wherein the composition of the drug comprises a large molecule protein.

10 . The electronic pill of claim 2 , wherein the pharmacokinetic data comprise expression of a protein in the patient.

11 . The electronic pill of claim 10 , wherein the expression of the protein in the patient is indicative of the patient's responsiveness to a therapy.

12 . The electronic pill of claim 11 , wherein the therapy comprises administration of the drug.

13 . The electronic pill of claim 12 , wherein the protein is present in the gastrointestinal tract of the patient.

14 . The electronic pill of claim 12 , wherein the protein is present in the blood of the patient.

15 . The electronic pill of claim 2 , wherein the at least one parameter relates to the a distribution of proteins in the gastrointestinal tract of the patient.

16 . The electronic pill of claim 15 , wherein the proteins comprise at least one member selected from the group consisting of P-glycoprotein and multidrug resistance protein.

17 . The electronic pill of claim 2 , wherein the delivery profile comprises a drug dispense rate of the drug versus time.

18 . The electronic pill of claim 2 , wherein the delivery profile comprises a drug dispense rate for the drug versus location in the gastrointestinal tract.

19 . The electronic pill of claim 2 , wherein the at least one parameter comprises the pharmacokinetic data, and the electronic pill is configured to sample the pharmacokinetic data during administration of the drug.

20 . The electronic pill of claim 2 , wherein the at least one parameter comprises the response of the patient to administration of the drug, and the electronic pill is configured to sample the response of the patient to administration of the drug during administration of the drug.

21 . The electronic pill of claim 2 , wherein the electronic pill is configured to adjust the delivery profile of the drug during administration of the drug.

22 . The electronic pill of claim 2 , wherein the electronic pill is configured to adjust the delivery profile of the drug after administration of the drug.

23 . The electronic pill of claim 2 , wherein the electronic pill is configured to determine the delivery profile once and to apply the delivery profile continuously during one or more administrations of the drug by the electronic pill.

24 . The electronic pill of claim 2 , further comprising a motor configured to move a piston to deliver the drug from the drug reservoir to the patient.

25 . The electronic pill of claim 2 , further comprising programmable memory.

26 . The electronic pill of claim 2 , further comprising a sensor configured to gather information relating to a location of the electronic pill in the gastrointestinal tract of the patient.

27 . The electronic pill of claim 26 , wherein the sensor comprises a member selected from the group consisting of a pH sensor and a sensor for CYP activity.

28 . A system, comprising:
an electronic pill according to claim 2 ; a unit configured to wirelessly gather data from the electronic pill.

29 . The system of claim 28 , further comprising a base station configured to gather data from the unit.

Assignees

• Progenity Inc

Inventors

• Shimizu Jeff

Classifications

• A61M2205/50

  with microprocessors or computers · CPC title

• A61M2210/1057

  Duodenum · CPC title

• A61B5/42

  Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems (A61B1/00, A61B5/4857, A61B5/486, A61B5/4866, A61B5/4869 take precedence) · CPC title

• A61M2210/106

  Small intestine · CPC title

• A61M2205/3523

  using telemetric means · CPC title