Peptide having titanium-binding ability

Patent metadata

Field	Value
Publication number	US-2018280577-A1
Application number	US-201715545679-A
Country	US
Kind code	A1
Filing date	Mar 7, 2017
Priority date	Jul 26, 2016
Publication date	Oct 4, 2018
Grant date	—

Abstract

The present invention relates to a peptide having the ability to bind specifically to the surface of titanium. The titanium-binding peptide according to the present invention is fixed securely to the titanium surface so that the activity of a physiologically active substance linked to the peptide can be stably maintained over a long period of time. Thus, the peptide can be effectively used for surgical regeneration therapy.

First claim

1 . A titanium-binding peptide represented by the amino acid sequence of SEQ ID NO: 1.

2 . The titanium-binding peptide of claim 1 , wherein the peptide binds to titanium without chemical modification.

3 . A peptide conjugate comprising a physiologically active peptide or protein linked to the titanium-binding peptide of claim 1 .

4 . The peptide conjugate of claim 3 , wherein the physiologically active peptide is selected from the group consisting of anti-inflammatory, anti-microbial, cell adhesion, bone tissue regeneration, and cell migration functional peptides.

5 . The peptide conjugate of claim 3 , wherein the physiologically active protein is selected from the group consisting of a tissue regeneration factor, a tissue growth factor, an intracellular transcription factor, an extracellular matrix protein, and an anti-inflammatory protein

6 . The peptide conjugate of claim 3 , wherein the peptide conjugate is represented by an amino acid sequence of SEQ ID NO: 3 or 4.

7 . A biomaterial comprising the titanium-binding peptide of claim 1 or a peptide conjugate thereof, comprising a physiologically active peptide or protein linked to said titanium-binding peptide.

8 . The biomaterial of claim 7 , wherein the biomaterial is any one selected from the group consisting of a titanium-coated metal, a titanium-containing metal, a titanium-coated natural polymer, a natural polymer mixed with titanium, a titanium-coated synthetic polymer, a synthetic polymer mixed with titanium, and an implant for in vivo implantation made of titanium.

9 . The biomaterial of claim 8 , wherein the titanium is preferably an alloy obtained by adding 5-7 wt % of aluminum, 3-5 wt % of vanadium, 0-0.25 wt % of iron and 0-0.2 wt % of oxygen to pure titanium oxide.

10 . The biomaterial of claim 8 , wherein the natural polymer is any one selected from the group consisting of collagen, alginic acid, propylene glycol, alginic acid, chondroitin sulfate, and chitosan.

11 . The biomaterial of claim 8 , wherein the synthetic polymer is any one selected from the group consisting of polylacticglycolic acid, poloxamer, and propylene glycol.

Assignees

• Nano Intelligent Biomedical Eng Corporation Co Ltd
• Seoul Nat Univ R&Db Foundation

Inventors

• Chung Chong-Pyoung
• Park Yoon Jeong
• Lee Jue-Yeon
• Kim Yeonsu
• Lee Dong Woo

Classifications

• A61L2430/12

  for dental implants or prostheses · CPC title

• C07K2319/00

  Fusion polypeptide · CPC title

• C07K14/51

  Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor · CPC title

• A61L27/06

  Titanium or titanium alloys · CPC title

• C07K7/08 Primary

  having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68) · CPC title