Localization systems and methods for an ingestible device

Patent metadata

Field	Value
Publication number	US-2018279908-A1
Application number	US-201815940407-A
Country	US
Kind code	A1
Filing date	Mar 29, 2018
Priority date	Mar 31, 2017
Publication date	Oct 4, 2018
Grant date	—

Abstract

Ingestible devices are disclosed that provide very high localization accuracy for the devices when present in the GI tract of a body. Related systems and methods are also disclosed.

First claim

1 . An ingestible device, comprising:
one or more processing devices; and one more machine readable hardware storage devices storing instructions that are executable by the one or more processing devices to determine a location of the ingestible device in a portion of a GI tract of a subject to an accuracy of at least 85%.

2 .- 10 . (canceled)

11 . The ingestible device of claim 1 , further comprising first and second light sources, wherein the first light source is configured to emit light at a first wavelength, and the second light source is configured to emit light at a second wavelength different from the first wavelength.

12 . The ingestible device of claim 11 , further comprising first and second detectors, wherein the first detector is configured to detect light at the first wavelength, and the second detector is configured to detect light at the second wavelength.

13 .- 37 . (canceled)

38 . A method, comprising:
determining a location of the ingestible medical device in a portion of a GI tract of a subject to an accuracy of at least 85%.

39 .- 47 . (canceled)

48 . The method of claim 38 , wherein determining the location of the ingestible device within the GI tract of a subject comprises determining reflected light signals within the GI tract, wherein the reflected signals comprise light of at least two different wavelengths.

49 . The method of claim 48 , wherein the reflected signals comprise light of at least three different wavelengths.

50 . The method of claim 48 , wherein:
the reflected light comprise first and second wavelengths; the first wavelength is between 495-600 nm; and the second wavelength is between 400-495 nm.

51 . The method of claim 50 , wherein the first and second wavelengths are separated by at least 50 nm.

52 . A method, comprising:
determining a location of an ingestible medical device within the GI tract of a subject based on measured reflected light signals within the GI tract, wherein the reflected signals comprise light of at least two different wavelengths.

53 . The method of claim 52 , wherein the reflected signals comprise light of at least three different wavelengths.

54 . The method of claim 52 , wherein:
the at least two different wavelengths comprise first and second wavelengths; the first wavelength is between 495-600 nm; and the second wavelength is between 400-495 nm.

55 . The method of claim 54 , wherein the first and second wavelengths are separated by at least 50 nm.

56 . A method for determining a location of an ingestible device within a gastrointestinal tract of a body, the method comprising:
transmitting a first illumination at a first wavelength and a second illumination at a second wavelength towards an environment external to a housing of the ingestible device; detecting a first reflectance from the environment resulting from the first illumination and a second reflectance from the environment resulting from the second illumination, wherein the first reflectance value is indicative of an amount of light in the first reflectance, and the second reflectance value is indicative of an amount of light in the second reflectance; storing a ratio of the first reflectance value and the second reflectance value in a data set, the data set including a plurality of values, each of the plurality of values corresponding to a respective ratio of a respective first reflectance and a respective second reflectance detected at a respective time; obtaining, from the data set, a first subset of values, the first subset of values corresponding to a first predetermined number of recent measurements; obtaining, from the data set, a second subset of values, the second subset of values corresponding to a second predetermined number of past measurements, the recent measurements being taken at a recent time range that is separated from a past time range when the past measurements were taken by at least a predetermined period of time; and identifying a change in the location of the ingestible device within the gastrointestinal tract of the body when a difference between a first mean value of the first subset of values and a second mean value of the second subset of values exceeds a threshold value.

57 . The method of claim 56 , wherein the first wavelength is in the green spectrum of light between 495-600 nm and the second wavelength is in the blue spectrum of light between 400-495 nm, and the first wavelength and the second wavelength are separated by at least 50 nm.

58 . The method of claim 56 , wherein the retrieving the first subset of values and the retrieving the second subset of values comprises:
obtaining a first raw subset of values by applying a first sliding window filter to the data set; obtaining a second raw subset of values by applying a second sliding window filter to the data set; determining the first subset of values by removing a first set of outliers from the first raw subset of values, the first set of outliers being identified based on a standard deviation of the first raw subset of values; and determining the second subset of values by removing a second set of outliers from the second raw subset of values, the second set of outliers being identified based on a standard deviation of the second raw subset of values.

59 .- 121 . (canceled)

Assignees

• Progenity Inc

Inventors

• Jones Mitchell Lawrence
• Liu Yi
• Bechtel Kate Leeann
• Wahl Christopher Loren

Classifications

• G16H40/67

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• A61B10/0045

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• A61B5/6861

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• A61B5/065 Primary

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