Process For Making Tablet Using Radiofrequency

Patent metadata

Field	Value
Publication number	US-2018263902-A1
Application number	US-201715463609-A
Country	US
Kind code	A1
Filing date	Mar 20, 2017
Priority date	Mar 20, 2017
Publication date	Sep 20, 2018
Grant date	—

Abstract

In one aspect the present invention features a process for making a tablet comprising the step of applying radiofrequency energy to a powder blend comprising lossy coated particles and at least one pharmaceutically active agent to sinter said powder blend into a tablet, said lossy coated particles comprising a substrate having a Q value of greater than 100 that is at least partially coated with a lossy coating comprising Hydrogenated Starch Hydrolysate.

First claim

What is claimed is:

1 . A process for making a tablet comprising the step of applying radiofrequency energy to a powder blend comprising lossy coated particles and at least one pharmaceutically active agent to sinter said powder blend into a tablet, said lossy coated particles comprising a substrate having a Q value of greater than 100 that is at least partially coated with a lossy coating comprising Hydrogenated Starch Hydrolysate.

2 . A process of claim 1 , wherein said substrate has a Q value of greater than 200.

3 . (canceled)

4 . A process of claim 1 , wherein said lossy coated particles have a Q value of greater than 100.

5 . A process of claim 1 , wherein said powder blend has a Q value of greater than 100.

6 . A process of claim 1 , wherein said powder blend comprises at least 20%, by weight, of said lossy coated particles.

7 . A process of claim 1 , wherein said lossy coated particles comprise from about 0.1 to about 2%, by weight, of Hydrogenated Starch Hydrolysate.

8 . A process of claim 1 , wherein said lossy coated particle comprises from about 0.1% to about 3%, by weight, water.

9 . A process of claim 1 , wherein said tablet disintegrates in the mouth when placed on the tongue in less than about 30 seconds.

10 . A process of claim 1 , wherein said tablet disintegrates in the mouth when placed on the tongue in less than about 15 seconds.

11 . The process of claim 1 , wherein said radiofrequency energy has a frequency of from about 13 MHz to about 40 MHz.

12 . A process of claim 1 , wherein said tablets are formed within a tablet die.

13 . A process of claim 1 , wherein said substrate comprises a starch, a sugar alcohol, or a sugar.

14 . A process of claim 1 , wherein said substrate comprises maltitol or mannitol.

15 . A process of claim 1 , wherein said substrate comprises said pharmaceutically active agent.

16 . A process of claim 1 , wherein the friability of the tablet is less than about 5%.

17 . A process of claim 1 , wherein the hardness of the tablet is 1 kp or greater.

18 . A sintered tablet comprising sintered lossy coated particles and at least one pharmaceutically active agent, wherein said lossy coated particles comprise a substrate that is at least partially coated with a lossy coating comprising Hydrogenated Starch Hydrolysate, wherein said substrate has a Q value of greater than 100, said tablet having a hardness of 1 kp or greater and wherein said tablet disintegrates in the mouth when placed on the tongue in less than about 15 seconds.

19 . (canceled)

20 . (canceled)

21 . The process of claim 17 wherein said tablet disintegrates in the mouth when placed on the tongue in less than about 15 seconds.

22 . The process of claim 1 wherein said powder blend comprises lossy coated particles separate from said at least one pharmaceutically active agent.

Assignees

• Johnson & Johnson Consumer Inc

Inventors

• Koll Gregory
• Mcnally Gerard
• Szymczak Christopher E

Classifications

• A61K9/5036

  Polysaccharides, e.g. gums, alginate; Cyclodextrin · CPC title

• A61K31/138

  Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine (atenolol A61K31/165; pindolol A61K31/404; timolol A61K31/5377) · CPC title

• A61K9/2059

  Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin · CPC title

• A61K9/50

  Microcapsules {having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals (A61K9/2081 takes precedence; particles with a single coating comprising drug A61K9/167)} · CPC title

• A61K9/0056 Primary

  Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals · CPC title