Device for residue handling minimizationwith vacuum-assisted separations

Patent metadata

Field	Value
Publication number	US-2018259492-A1
Application number	US-201715455262-A
Country	US
Kind code	A1
Filing date	Mar 10, 2017
Priority date	Mar 10, 2017
Publication date	Sep 13, 2018
Grant date	—

Abstract

A device for collection of residue from separation columns. A manifold provides for multiple sample ports that are fluidly connected to a vacuum port by at least one channel. Residue from the separation columns is pulled through the sample ports, into the channel, and then to the vacuum port. From the vacuum port the residue can be moved, under the force of the vacuum, directly to a drain or to a collection vessel connected with a drain.

First claim

What is claimed is:

1 . A device for vacuum removal of residue, comprising:
a manifold defining a longitudinal direction, a top surface, and a bottom surface; a plurality of sample ports positioned along the top surface of the manifold; a vacuum port positioned on the manifold; and at least one channel fluidly connecting the vacuum port with the plurality of sample ports.

2 . The device for vacuum removal of residue as in claim 1 , wherein the sample ports are arranged in one or more rows extending along the longitudinal direction.

3 . The device for vacuum removal of residue as in claim 1 , wherein the sample ports are arranged in at least two rows extending along the longitudinal direction.

4 . The device for vacuum removal of residue as in claim 1 , wherein the manifold defines a plurality of side surfaces, and wherein the vacuum port is positioned on one of the side surfaces.

5 . The device for vacuum removal of residue as in claim 1 , further comprising a plastic block that defines the manifold, the plurality of sample ports, the vacuum port, and the at least one channel.

6 . The device for vacuum removal of residue as in claim 1 , wherein the plurality of sample ports are arranged into columns and rows, wherein the rows extend along the longitudinal direction and the columns are orthogonal to the rows.

7 . The device for vacuum removal of residue as in claim 6 , wherein the vacuum port comprises a plurality of vacuum ports, each vacuum port of the plurality of vacuum ports aligned with one of the columns or rows of sample ports and fluidly connected thereto.

8 . The device for vacuum removal of residue as in claim 7 , wherein the vacuum ports are fluidly connected with the at least one channel.

9 . The device for vacuum removal of residue as in claim 7 , wherein the at least one channel comprises a plurality of legs extending along the longitudinal direction of the manifold.

10 . The device for vacuum removal of residue as in claim 9 , wherein each leg of the plurality of channels is positioned directly beneath one of the rows of sample ports.

11 . The device for vacuum removal of residue as in claim 9 , further comprising a plurality of separation columns, each column attached to one of the sample ports, each separation column containing a resin for separating one or more analytes.

12 . The device for vacuum removal of residue as in claim 9 , further comprising a collection vessel fluidly connected with the vacuum port.

13 . A device for vacuum removal of residue, comprising:
a manifold constructed of a single block of material and defining a longitudinal direction, a top surface, and a bottom surface; a plurality of sample ports positioned along the top surface of the manifold and created by boring into the block of material; a vacuum port positioned on the manifold and created by boring into the block of material; and at least one channel fluidly connecting the vacuum port with the plurality of sample ports and created by boring into the block of material.

14 . The device for vacuum removal of residue as in claim 13 , wherein the sample ports are arranged in one or more rows extending along the longitudinal direction.

15 . The device for vacuum removal of residue as in claim 13 , wherein the sample ports are arranged in at least two rows extending along the longitudinal direction.

16 . The device for vacuum removal of residue as in claim 13 , wherein the manifold defines a plurality of side surfaces, and wherein the vacuum port is positioned on one of the side surfaces.

17 . The device for vacuum removal of residue as in claim 13 , further comprising a plastic block that defines the manifold, the plurality of sample ports, the vacuum port, and the at least one channel.

Assignees

• Savannah River Nuclear Solutions Llc

Inventors

• Diprete David P
• Pak Donald J
• Diprete Cecilia C
• Reboul Scott H
• Whiteside Tad S

Classifications

• G01N30/26

  Conditioning of the fluid carrier; Flow patterns · CPC title

• B01L3/50255

  Multi-well filtration · CPC title

• B01D15/22 Primary

  relating to the construction of the column · CPC title

• G01N30/06

  Preparation · CPC title

• G01N1/28

  Preparing specimens for investigation {including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q}(mounting specimens on microscopic slides G02B21/34; means for supporting the objects or the materials to be analysed in electron microscopes H01J37/20 {; laboratory gas handling apparatus B01L5/00}) · CPC title