Therapeutic and imaging compositions and uses thereof

Patent metadata

Field	Value
Publication number	US-2018258192-A1
Application number	US-201815978872-A
Country	US
Kind code	A1
Filing date	May 14, 2018
Priority date	May 7, 2013
Publication date	Sep 13, 2018
Grant date	—

Abstract

Various embodiments of the present invention are directed to polyrotaxanes comprising a poloxamer core and at least one cyclodextrin and methods for treating Niemann-Pick type C (NPC) and imaging (e.g., MRI) using the polyrotaxanes various embodiments of the present invention.

First claim

1 . (canceled)

2 . A polyrotaxane comprising the general formula:

or a salt thereof,
wherein:
n is an integer from 1 to 30;
C and C′ are the same or different and represent endcapping groups of the formula

wherein:
is a (C 1 -C 6 )hydrocarbylene group,
G 1 and G 2 , together, form a radical having the formula:

wherein each L 2 is independently a bond acyl; each G 3 is a substituted or unsubstituted (C 6 -C 50 )hydrocarbyl group, interrupted by 0 to 5 groups chosen from —O—, —NH— and —S—;
and each s is independently an integer from 1 to 5; and
t is an integer from 2 to 5;
B is a polyalkylene oxide polymer; and
A is a beta cyclodextrin.

2 . The polyrotaxane of claim 2 , wherein G 3 substituted or unsubstituted —O—(C 6 -C 50 )alkyl group or a substituted or unsubstituted (C 6 -C 12 )aryl group.

3 . The polyrotaxane of claim 2 , wherein G 3 is a cholesteryl group.

4 . The polyrotaxane of claim 2 , where n is an integer from 5 to 15.

5 . The polyrotaxane of claim 2 , wherein n is an integer from 3 to 11.

6 . A pharmaceutical composition comprising the polyrotaxane of claim 2 and a pharmaceutically acceptable carrier.

Assignees

• Purdue Research Foundation

Inventors

• Thompson David H
• Kulkarni Aditya
• Collins Christopher
• Mondjinou Yawo

Classifications

• A61P3/06

  Antihyperlipidemics · CPC title

• A61K31/765

  Polymers containing oxygen · CPC title

• A61P3/00

  Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) · CPC title

• C08G83/007

  Polyrotaxanes; Polycatenanes · CPC title

• C08B37/0015 Primary

  Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes · CPC title