Multi chamber syringe unit and method of preparing a multi chamber syringe

Patent metadata

Field	Value
Publication number	US-2018256818-A1
Application number	US-201615762276-A
Country	US
Kind code	A1
Filing date	Sep 29, 2016
Priority date	Oct 2, 2015
Publication date	Sep 13, 2018
Grant date	—

Abstract

A multi chamber syringe unit includes a longitudinal body with side wall, distal end side, proximal end side opposite to distal end side, an interior limited by side wall between distal end side and proximal end side and distal opening arranged in distal end side for providing a liquid out of the body. The syringe further includes a separating element arranged in the interior of the body such that distal chamber and proximal chamber are formed in the interior of the body, wherein the separating element seals the distal chamber from the proximal chamber. The syringe has a bypass arrangement provided in the side wall of distal chamber of the body. A first pharmaceutical liquid is arranged in distal chamber of the body and second pharmaceutical liquid in proximal chamber of the body. The multi chamber syringe unit allows for adequately administering plural pharmaceutical liquids by injection.

First claim

1 . A multi chamber syringe unit comprising:
a longitudinal body with a side wall, a distal end side, a proximal end side opposite to the distal end side, an interior limited by the side wall between the distal end side and the proximal end side and a distal opening arranged in the distal end side for providing a liquid out of the body; a separating element arranged in the interior of the body such that a distal chamber and a proximal chamber are formed in the interior of the body, wherein the separating element seals the distal chamber from the proximal chamber; and a bypass arrangement provided in the side wall of the distal chamber of the body; a first pharmaceutical liquid arranged in the distal chamber of the body; and a second pharmaceutical liquid arranged in the proximal chamber of the body.

2 . The multi chamber syringe unit according to claim 1 , wherein the first pharmaceutical liquid is an anaesthetic and the second pharmaceutical liquid comprises a therapeutic active ingredient.

3 . The multi chamber syringe unit according to claim 2 , wherein the anaesthetic is an amid based anaesthetic.

4 . The multi chamber syringe unit according to claim 1 , wherein the first pharmaceutical liquid comprises a first therapeutic active ingredient and the second pharmaceutical liquid comprises a second therapeutic active ingredient.

5 . The multi chamber syringe unit according to claim 1 , wherein the first pharmaceutical liquid comprises an enzyme and the second pharmaceutical liquid comprises a therapeutic active ingredient.

6 . The multi chamber syringe unit according to claim 5 , wherein the enzyme is a hyaluronidase.

7 . The multi chamber syringe unit according to claim 2 , wherein the therapeutic active ingredient comprises a protein.

8 . The multi chamber syringe unit according to claim 1 , wherein the first pharmaceutical liquid and the second pharmaceutical liquid together form a gel such as a hydrogel or complex upon mixing.

9 . The multi chamber syringe unit according to claim 1 , wherein the bypass arrangement is located adjacent to the distal end side of the body.

10 . The multi chamber syringe unit according to claim 9 , wherein the body and the separating element are arranged such that the distal chamber is essentially emptied when the separating element is moved to the bypass arrangement.

11 . The multi chamber syringe unit according to claim 1 , comprising a needle connected to the distal opening of the distal end side of the body.

12 . A method of preparing a multi chamber syringe having a longitudinal body with a side wall, a distal end side, a proximal end side opposite to the distal end side, an interior limited by the side wall between the distal end side and the proximal end side and a distal opening arranged in the distal end side for providing a liquid out of the multi chamber syringe, comprising:
sterilizing the multi chamber syringe; filling a first pharmaceutical liquid into the interior of the body adjacent to its distal end side; providing a separating element in the interior of the body of the multi chamber syringe such that a distal chamber and a proximal chamber are formed in the interior of the body; and filling a second pharmaceutical liquid into the proximal chamber of the interior of the body.

13 . The method according to claim 12 , wherein the first pharmaceutical liquid comprises any one of the group consisting of an anaesthetic, a first therapeutic active ingredient, a first hydrogel component and an enzyme such as hyaluronidase, and the second pharmaceutical liquid comprises a second therapeutic active ingredient or a second hydrogel component.

14 . The method according to claim 12 , further comprising: providing a closing element in the interior of the body of the multi chamber syringe such that the proximal chamber is closed.

15 . The method according to claim 12 , wherein the multi chamber syringe is aligned with the distal end side of the body during all steps of the method.

Assignees

• Hoffmann La Roche

Inventors

• Lümkemann Jörg
• Mahler Hanns-Christian
• Werk Toblas

Classifications

• A61M2202/07

  Proteins · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A61K38/47

  acting on glycosyl compounds (3.2), e.g. cellulases, lactases · CPC title

• A61K9/0019

  Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title

• A61M2207/00

  Methods of manufacture, assembly or production · CPC title