Biodegradable injectable gel

Patent metadata

Field	Value
Publication number	US-2018250435-A1
Application number	US-201615754393-A
Country	US
Kind code	A1
Filing date	Aug 23, 2016
Priority date	Aug 24, 2015
Publication date	Sep 6, 2018
Grant date	—

Abstract

The present invention relates to a triblock copolymer having a polyethylene glycol-poly(D,L-lactide)-polyethylene glycol skeleton.

First claim

1 . A triblock copolymer having a polyethylene glycol-poly(D,L-lactide)-polyethylene glycol skeleton.

2 . The triblock polymer according to claim 1 , comprising a repeating unit represented by formula I:

wherein,
n is 10 to 1000, and
m is 1 to 100.

3 . A biodegradable injectable gel, comprising: the triblock copolymer according to claim 1 , chitosan, and a self-assembling peptide.

4 . The biodegradable injectable gel according to claim 3 , wherein the self-assembling peptide is (RADA) 4 .

5 . A method for producing a triblock copolymer having a polyethylene glycol-poly(D,L-lactide)-polyethylene glycol skeleton, comprising:
a step for reacting the following:

wherein, n is 10 to 1000, with L-lactide to obtain

wherein, m is 1 to 100,
a step for reacting the resulting

to obtain

followed by de-protecting the resulting

to obtain

and, a step for reacting the resulting

with di(N-succinimidyl)carbonate to obtain

6 . A crosslinking agent comprising the triblock copolymer according to claim 1 .

Assignees

• 3 D Matrix Ltd
• Univ Tokyo Science Found

Inventors

• Otsuka Hidenori
• Matsukuma Daisuke
• Matsuda Noriaki

Classifications

• C08L71/02

  Polyalkylene oxides · CPC title

• C08L5/08

  Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof · CPC title

• A61L27/18 Primary

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• C08L2203/02

  for biomedical use · CPC title

• C08K5/3415

  Five-membered rings · CPC title