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Single domain antibodies capable of modulating bace activity
US2018230232A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2018230232-A1 |
| Application number | US-201815872498-A |
| Country | US |
| Kind code | A1 |
| Filing date | Jan 16, 2018 |
| Priority date | Apr 3, 2008 |
| Publication date | Aug 16, 2018 |
| Grant date | — |
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- Title
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Abstract
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Described are single domain antibodies with a specificity for BACE1. More specifically, described are single variable-domain antibodies derived from camelids that bind to BACE1 and are capable of inhibiting the activity of BACE1. The antibodies can be used for research and medical applications. Specific applications include the use of BACE1-specific antibodies for the treatment of Alzheimer's disease.
First claim
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1 - 9 . (canceled) 10 . A single domain antibody, devoid of a light chain, wherein the single domain antibody specifically binds beta secretase (BACE1) and inhibits cleavage of beta amyloid precursor protein (APP) in an endosomal compartment of a cell as determined in a cellular assay when the single-domain antibody is provided to the extracellular medium of the cell in the cellular assay. 11 . The single domain antibody of claim 10 , wherein the single domain antibody is derived from an antibody raised in a Camelidae species. 12 . A medicament comprising: the single domain antibody of claim 10 ; and at least one pharmaceutically acceptable carrier. 13 . The single-domain antibody of claim 10 , wherein the single-domain antibody is a VHH antibody. 14 . The single-domain antibody of claim 10 , wherein the single-domain antibody comprises four framework regions (FRs) and three complementary determining regions (CDRs). 15 . The single-domain antibody of claim 14 , wherein the four FRs and three CDRs are in sequence: FR-1-CDR1-FR2-CDR2-FR3-CDR3-FR4. 16 . The single-domain antibody of claim 10 , wherein the antibody is bivalent. 17 . The single-domain antibody of claim 10 , wherein the single-domain antibody is bi-specific.
Assignees
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Classifications
Antagonist effect on antigen, e.g. neutralization or inhibition of binding · CPC title
Complementarity determining region [CDR] · CPC title
- C07K16/40Primary
against enzymes · CPC title
Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value · CPC title
Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody® · CPC title
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- What does patent US2018230232A1 cover?
- Described are single domain antibodies with a specificity for BACE1. More specifically, described are single variable-domain antibodies derived from camelids that bind to BACE1 and are capable of inhibiting the activity of BACE1. The antibodies can be used for research and medical applications. Specific applications include the use of BACE1-specific antibodies for the treatment of Alzheimer's d…
- Who is the assignee on this patent?
- Vib Vzw, Katholieke Univ Leuven K U Leuven R & D, Univ Brussel Vrije
- What technology area does this patent fall under?
- Primary CPC classification C07K16/40. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Thu Aug 16 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).