Core stabilized microcapsules, method of their preparation and uses thereof

Patent metadata

Field	Value
Publication number	US-2018207451-A1
Application number	US-201815924331-A
Country	US
Kind code	A1
Filing date	Mar 19, 2018
Priority date	Dec 31, 2009
Publication date	Jul 26, 2018
Grant date	—

Abstract

The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within a inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.

First claim

What is claimed is:

1 . A process for preparing microcapsules having a core encapsulated within an inorganic oxide shell, said process comprising:
(a) preparing an oil-in-water emulsion by emulsification of an oily phase comprising at least one active agent and at least one phase changing material, in an aqueous phase, wherein at least one of said oily phase and aqueous phase comprise a sol-gel precursor; (b) adjusting the pH of the emulsion to be in the range of 3 to 5; and (c) subjecting said emulsion to microcapsule forming conditions; thereby obtaining said microcapsules; wherein said core comprises at least one active agent and at least one phase changing material which are both surrounded by an inorganic oxide shell.

2 . The process according to claim 1 wherein said at least one active agent is selected from the group consisting of a pharmaceutical agent, a cosmetic agent and a dermatological agent.

3 . The process according to claim 1 , wherein said at least one active agent is a dermatological agent selected from the group consisting of anti-fungal agents, anti-bacterial agents, anti-inflammatory agents, anti-puritic agents, anti-psoriatic agents, anti-acne agents, anti-rosacea agents, and any combinations thereof.

4 . The process according to claim 1 , wherein said at least one active agent is an anti acne agent selected from the group consisting of benzoyl peroxide, retinoid, and mixtures thereof.

5 . The process according to claim 1 , further comprising adding at least one nanoparticle of at least one inorganic oxide to said aqueous phase prior, during or after preparation of oil-in-water emulsion of step (a).

6 . The process according to claim 1 , further comprising adding an inorganic oxide salt to said aqueous phase prior, during or after emulsification of step (a).

7 . The process according to claim 1 , wherein said at least one phase changing material is selected from the group consisting of natural or synthetic paraffin, aliphatic alcohols, fatty acids or any combination thereof.

8 . The process according to claim 1 , wherein said oily phase comprises a sol-gel precursor.

9 . Microcapsules obtained by the process according to claim 1 .

Assignees

• Sol Gel Tech Ltd

Inventors

• Toledano Ofer
• Bar-Simantov Haim
• Sertchook Hanan
• Fireman-Shoresh Sharon
• Marco Dorit

Classifications

• A61K9/5115

  Inorganic compounds · CPC title

• A61K8/25

  Silicon; Compounds thereof · CPC title

• F28D20/023

  the latent heat storage material being enclosed in granular particles or dispersed in a porous, fibrous or cellular structure · CPC title

• A61K9/501

  Inorganic compounds · CPC title

• A61K47/38

  Cellulose; Derivatives thereof · CPC title