B7-h1, a novel immunoregulatory molecule

Patent metadata

Field	Value
Publication number	US-2018201684-A1
Application number	US-201715796034-A
Country	US
Kind code	A1
Filing date	Oct 27, 2017
Priority date	Nov 30, 1999
Publication date	Jul 19, 2018
Grant date	—

Abstract

The invention provides novel polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides.

First claim

1 . (canceled)

2 . A method for inhibiting the co-stimulatory activity of hB7-H1, wherein said method comprises contacting cells with an antibody that inhibits the co-stimulatory activity of hB7-H1 under conditions wherein said antibody inhibits the co-stimulatory activity of hB7-H1, wherein said hB7-H1 comprises the amino acid sequence set forth in SEQ ID NO: 1.

Assignees

• Mayo Found Medical Education & Res

Inventors

• Chen Lieping

Classifications

• C07K2319/74

  containing a fusion for binding to a cell surface receptor · CPC title

• G01N33/502

  for testing non-proliferative effects · CPC title

• C07K16/2827 Primary

  against B7 molecules, e.g. CD80, CD86 · CPC title

• C07K14/47 Primary

  from mammals · CPC title

• C07K2317/24

  containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered · CPC title