Flexible analyte sensors

Patent metadata

Field	Value
Publication number	US-2018199873-A1
Application number	US-201815874503-A
Country	US
Kind code	A1
Filing date	Jan 18, 2018
Priority date	Jan 19, 2017
Publication date	Jul 19, 2018
Grant date	—

Abstract

Flexible analyte sensors are provided. Flexible analyte sensors may be flexible continuous analyte sensors that facilitate continuous monitoring of an analyte such as blood glucose. The flexible analyte sensor may have a relatively flexible conductive or non-conductive core, may be formed from a plurality of substantially planar layers, or may be configured to transform from a freestanding sensor ex vivo to a non-freestanding sensor in vivo.

First claim

What is claimed is:

1 . A continuous analyte sensor configured for in vivo use, the continuous analyte sensor comprising:
an elongated conductive body comprising a working electrode, wherein the elongated conductive body is configured to be a freestanding elongated conductive body ex vivo and a non-freestanding elongated conductive body in vivo; and a membrane covering at least a portion of the working electrode, wherein the membrane comprises an enzyme layer.

2 . The continuous analyte sensor of claim 1 , wherein the elongated conductive body is configured to transform from the freestanding elongated conductive body to the non-freestanding elongated conductive body responsive to contact between at least a portion of the elongated conductive body and tissue of a patient.

3 . The continuous analyte sensor of claim 1 , wherein the elongated conductive body is configured to transform from the freestanding elongated conductive body to the non-freestanding elongated conductive body at a transition temperature of between seventy-eight and one-hundred degrees Fahrenheit.

4 . The continuous analyte sensor of claim 1 , wherein the elongated conductive body is configured to transform from the freestanding elongated conductive body to the non-freestanding elongated conductive body responsive to absorption of a fluid from patient tissue by at least a portion of the elongated conductive body.

5 . The continuous analyte sensor of claim 1 , wherein the elongated conductive body is configured to transform from the freestanding elongated conductive body to the non-freestanding elongated conductive body responsive to a chemical reaction between a fluid from patient tissue and at least a portion of the elongated conductive body.

6 . The continuous analyte sensor of claim 1 , wherein the elongated conductive body is configured to transform from the freestanding elongated conductive body to the non-freestanding elongated conductive body responsive to an electromagnetic field generated by sensor electronics for the continuous analyte sensor.

7 . The continuous analyte sensor of claim 1 , wherein the elongated conductive body comprises an elongated conductive core.

8 . The continuous analyte sensor of claim 1 , wherein the elongated conductive body comprises an elongated polymeric core.

9 . The continuous analyte sensor of claim 1 , wherein the elongated conductive body comprises a plurality of substantially planar layers.

10 . The continuous analyte sensor of claim 1 , wherein, in vivo, the elongated conductive body has a buckling force of less than 0.01 N.

11 . The continuous analyte sensor of claim 1 , wherein the non-freestanding elongated conductive body has a weight under gravity and a buckling force that is less than the weight under gravity.

12 . A continuous analyte sensor system comprising:
a continuous analyte sensor comprising:
an elongated conductive body comprising a working electrode, wherein the elongated conductive body comprises a plurality of substantially planar layers, and wherein a portion of the plurality of substantially planar layers that is configured to extend from a housing of a continuous analyte sensor system has, in aggregate, a buckling force of less than 0.25 Newtons (N), and
a membrane covering at least a portion of the working electrode, wherein the membrane comprises an enzyme layer; and
sensor electronics configured to process sensor signals from the continuous analyte sensor, wherein the sensor electronics are disposed in a housing configured to attach to the exterior of a patient's skin.

13 . The continuous analyte sensor system of claim 12 , wherein, in vivo, the elongated conductive body has a buckling force of less than 0.01 N.

14 . The continuous analyte sensor system of claim 12 , wherein the non-freestanding elongated conductive body has a weight under gravity and a buckling force that is less than the weight under gravity.

Assignees

• Dexcom Inc

Inventors

• Wang Shanger
• Headen Devon M
• Bohm Sebastian
• Hughes Jonathan
• Lee Ted Tang
• Simpson Peter C
• Zou Jiong

Classifications

• G16H40/67

  for remote operation · CPC title

• C12Q1/54

  involving glucose or galactose · CPC title

• C12Q1/006

  for glucose · CPC title

• C12Q1/002

  Electrode membranes · CPC title

• A61B5/14865 Primary

  invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors · CPC title