Controllably Degradable Compositions and Methods

Patent metadata

Field	Value
Publication number	US-2018193518-A1
Application number	US-201615739217-A
Country	US
Kind code	A1
Filing date	Jun 23, 2016
Priority date	Jun 24, 2015
Publication date	Jul 12, 2018
Grant date	—

Abstract

Methods, compositions, kits, and drug delivery devices are provided for treating, adhering, or sealing biological tissues. The methods include combining a first solution that includes an oligomer/polymer component and a second solution that includes a dendrimer component, and at least one of the oligomer/polymer component and dendrimer component includes at least one substituent that is capable of photoreversible dimerization. The reversible dimerization of the substituent may allow for the reversible dimerization and/or polymerization of one or more components. The substituent that is capable of photoreversible dimerization may be active by the application of light, such as UV light.

First claim

1 . A method for treating, adhering, or sealing biological tissue, the method comprising:
providing a first solution comprising a polymer component having three or more aldehyde groups, wherein the polymer component comprises two or more oligomer units substituted with one or more first substituents capable of photoreversible dimerization, wherein the one or more first substituents capable of photoreversible dimerization are dimerized; providing a second solution comprising a dendrimer component, wherein the dendrimer component comprises a dendrimer having at least 2 branches with one or more surface groups; combining the first and second solutions together to produce an adhesive formulation and contacting one or more biological tissues with the adhesive formulation; and allowing the adhesive formulation to cure in contact with the one or more biological tissues.

2 . The method of claim 1 , wherein the dendrimer is substituted with one or more second substituents capable of photoreversible dimerization.

3 . The method of claim 2 , wherein the first and second substituents capable of photoreversible dimerization are the same.

4 . The method of claim 2 , further comprising contacting the adhesive formulation with light having a wavelength sufficient to dimerize the second substituent capable of photoreversible dimerization.

5 . The method of claim 4 , wherein allowing the adhesive formulation to cure and contacting the adhesive formulation with light are performed simultaneously.

6 . The method of claim 4 , further and subsequently comprising contacting the adhesive formulation with light having a wavelength sufficient to reverse the dimerization of the first and/or second substituents capable of photoreversible dimerization.

7 . The method of claim 1 , wherein at least one of the two or more oligomer units comprises an oligosaccharide.

8 - 11 . (canceled)

12 . The method of claim 1 , wherein the method further comprises contacting the adhesive formulation with an enzyme effective to degrade the polymer component.

13 . (canceled)

14 . The method of claim 1 , wherein the method further comprises contacting the adhesive formulation with an amine effective to alter the equilibrium of imine bond formation.

15 . (canceled)

16 . The method of claim 1 , wherein the method further and subsequently comprises altering the pH of the adhesive formulation in an amount effective to facilitate degradation of the polymer.

17 - 19 . (canceled)

20 . A method for treating, adhering, or sealing biological tissue, the method comprising:
providing a first solution comprising an oligomer/polymer component having three or more aldehyde groups, wherein the oligomer/polymer component comprises two or more oligomer units substituted with one or more first substituents capable of photoreversible dimerization; providing a second solution comprising a dendrimer component, wherein the dendrimer component comprises a dendrimer having at least 2 branches with one or more surface groups; combining the first and second solutions together to produce an adhesive formulation and contacting one or more biological tissues with the adhesive formulation; allowing the adhesive formulation to cure in contact with the one or more biological tissues; and contacting the adhesive formulation with light having a wavelength sufficient to dimerize the first substituent capable of photoreversible dimerization to convert at least a portion of the oligomer/polymer component to a polymer.

21 . The method of claim 20 , wherein the dendrimer is substituted with one or more second substituents capable of photoreversible dimerization.

22 . The method of claim 21 , wherein the first and second substituents capable of photoreversible dimerization are the same.

23 - 27 . (canceled)

28 . The method of claim 20 , wherein allowing the adhesive formulation to cure and contacting the adhesive formulation with light are performed simultaneously.

29 . The method of claim 20 , further and subsequently comprising contacting the adhesive formulation with light having a wavelength sufficient to reverse the dimerization of the first and/or second substituents capable of photoreversible dimerization.

30 - 37 . (canceled)

38 . A kit for making an adhesive comprising:
a first part which includes a first solution comprising an oligomer/polymer component having three or more aldehydes, wherein the oligomer/polymer component comprises two or more oligomer units substituted with one or more first substituents capable of photoreversible dimerization; and a second part which includes a second solution comprising a dendrimer component, wherein the dendrimer component comprises a dendrimer having at least 2 branches with one or more surface groups.

39 . The kit of claim 38 , wherein the one or more first substituents capable of photoreversible dimerization of the first part are dimerized.

40 . The kit of claim 38 , wherein at least one of the two or more oligomer units comprises an oligosaccharide.

41 - 44 . (canceled)

45 . The kit of claim 38 , wherein the dendrimer is substituted with one or more second substituents capable of photoreversible dimerization.

46 . The kit of claim 45 , wherein the first and second substituents capable of photoreversible dimerization are the same.

47 - 48 . (canceled)

49 . The kit of claim 38 , further comprising a UV light source to activate or deactivate the first and/or second substituents capable of photoreversible dimerization.

50 . A therapeutic or prophylactic composition comprising:
an oligomer/polymer component having three or more aldehydes, wherein the oligomer/polymer component comprises two or more oligomer units substituted with one or more first substituents capable of photoreversible dimerization; a dendrimer component, wherein the dendrimer component comprises a dendrimer having at least 2 branches with one or more surface groups; and at least one drug or cell combined with the at least one of the oligomer/polymer component and dendrimer component.

51 . The composition of claim 50 , wherein the one or more first substituents capable of photoreversible dimerization of the oligomer/polymer component are dimerized.

52 . The composition of claim 50 , wherein the dendrimer is substituted with one or more second substituents capable of photoreversible dimerization.

53 . The composition of claim 52 , wherein the first and second substituents capable of photoreversible dimerization are the same.

54 - 55 . (canceled)

56 . The composition of claim 50 , wherein the two or more oligomer units comprise an oligosaccharide.

57 - 60 . (canceled)

Assignees

• Massachusetts Inst Technology

Inventors

• Artzi Natalie
• Edelman Elazer R
• Kelmansky Regina
• Cervantes Marc Mier
• Zhang Yi

Classifications

• A61L24/043 Primary

  Mixtures of macromolecular materials · CPC title

• A61L24/0015

  Medicaments; Biocides · CPC title

• A61L26/0052

  Mixtures of macromolecular compounds · CPC title

• A61L26/0066

  Medicaments; Biocides · CPC title

• C08L5/02

  Dextran; Derivatives thereof · CPC title