Single-helical gold nanoparticle superstructures and methods of making

Patent metadata

Field	Value
Publication number	US-2018169754-A1
Application number	US-201715842625-A
Country	US
Kind code	A1
Filing date	Dec 14, 2017
Priority date	Dec 16, 2016
Publication date	Jun 21, 2018
Grant date	—

Abstract

Described herein are metal nanoparticle superstructures and methods and compounds for making the same.

First claim

What is claimed is:

1 . A metal nanoparticle superstructure comprising a plurality of metal nanoparticles positioned in an essentially single helical assembly.

2 . The metal nanoparticle superstructure of claim 1 , wherein the single helical assembly comprises a helical pitch of about 75 to about 115 nm.

3 . The metal nanoparticle superstructure of claim 1 , wherein an interparticle distance between metal nanoparticles in the metal nanoparticle superstructure is less than about 4 nm.

4 . The metal nanoparticle superstructure of claim 1 , wherein the metal nanoparticles have a length to width ratio of greater than about 1.

5 . The metal nanoparticle superstructure of claim 1 , wherein the metal nanoparticles have a width of about 2 to about 16 nm and a length of about 8 to about 30 nm.

6 . The metal nanoparticle superstructure of claim 1 , wherein the plurality of metal nanoparticles comprises gold.

7 . The metal nanoparticle superstructure of claim 1 , wherein the plurality of metal nanoparticles comprises palladium or silver.

8 . The metal nanoparticle superstructure of claim 1 , wherein the metal nanoparticle superstructure is produced by contacting a metal or metal salt with a compound of the following formula I:

wherein:
R is a C 6 -C 24 aliphatic or aromatic moiety;
X is an optional N—(C 1 -C 5 ) amide;
L is a linking moiety; and
PEP M-Ox is a peptide having an affinity to the metal or metal salt, where at least one methionine residue is oxidized.

9 . The metal nanoparticle superstructure of claim 8 , wherein PEP M-Ox is AYSSGAPPM ox PPF.

10 . The metal nanoparticle superstructure of claim 8 , wherein R is an C 14 -C 20 aliphatic moiety.

11 . A method for producing a metal nanoparticle superstructure comprising combining a metal or metal salt with a compound of the following formula I:

wherein:
R is a C 6 -C 24 aliphatic or aromatic moiety;
X is an optional N—(C 1 -C 5 ) amide;
L is a linking moiety; and
PEP M-Ox is a peptide having an affinity to the metal or metal salt, where at least one methionine residue in the peptide is oxidized.

12 . The method of claim 11 , wherein the metal salt is used, and is a salt comprising gold, a salt comprising silver or a salt comprising palladium.

13 . The method of claim 11 , wherein the metal or metal salt is combined with the compound of formula I in the presence of a buffering agent.

14 . The method of claim 11 , wherein PEP M-Ox is AYSSGAPPM ox PPF.

15 . The method of claim 11 , wherein R is an C 14 -C 20 aliphatic moiety.

16 . The method of claim 11 , wherein the metal nanoparticle superstructure has a single helical assembly.

17 . The method of claim 11 , wherein the compound of formula (I) has the structure:

wherein R and PEP M-Ox are as previously defined.

18 . The method of claim 16 , wherein the single helical assembly comprises a helical pitch of about 75 to about 115 nm.

19 . The method of claim 11 , wherein an interparticle distance between metal nanoparticles in the metal nanoparticle superstructure are less than about 4 nm.

20 . The method of claim 11 , wherein metal nanoparticles of the metal nanoparticle superstructure have a length to width ratio of greater than about 1.

21 . A compound of the following formula:

wherein:
R is a C 6 -C 24 aliphatic or aromatic moiety; and
PEP M-Ox is a peptide having an affinity to a metal or metal salt, where at least one methionine residue in the peptide is oxidized.

22 . The compound of claim 21 , wherein PEP M-Ox is AYSSGAPPM ox PPF.

23 . The compound of claim 21 , wherein the metal or metal salt comprises gold, silver, or palladium.

24 . The compound of claim 21 , wherein R is a C 16 -C 24 aliphatic moiety.

Assignees

• Univ Of Pittsburgh Of The Commomwealth System Of Higher Education
• Univ Pittsburgh Commonwealth Sys Higher Education

Inventors

• Rosi Nathaniel L
• Merg Andrea David

Classifications

• B22F1/0018

  Operations & Transport · mapped topic

• B22F2001/0037

  Operations & Transport · mapped topic

• C07K7/08

  having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68) · CPC title

• B22F2301/255

  Silver or gold · CPC title

• B82B3/0066

  Orienting nanostructures · CPC title