Controllably Degradable Compositions and Methods

Patent metadata

Field	Value
Publication number	US-2018161362-A1
Application number	US-201815882613-A
Country	US
Kind code	A1
Filing date	Jan 29, 2018
Priority date	Dec 23, 2013
Publication date	Jun 14, 2018
Grant date	—

Abstract

Methods for treating, adhering, or sealing biological tissue are provided. The methods include combining solutions containing a polymer component and a dendrimer component capable of reacting with each other, and at least one of the components includes a substituent capable of photoreversible dimerization that can be reversibly dimerized. Drug delivery compositions and kits containing these two components also are provided.

First claim

We claim:

1 . A kit for making an adhesive comprising:
a first part which includes a first solution comprising a polymer component, wherein the polymer component comprises a polymer; and a second part which includes a second solution comprising a dendrimer component, wherein the dendrimer component comprises a dendrimer having at least 2 branches with one or more surface groups; wherein at least one of the polymer and the dendrimer is substituted with one or more substituents capable of photoreversible dimerization.

2 . The kit of claim 1 , further comprising a UV light source to activate or deactivate the one or more substituents capable of photoreversible dimerization.

3 . The kit of claim 1 , wherein less than 75% of the surface groups comprise at least one primary or secondary amine.

4 . The kit of claim 1 , wherein 100% of the surface groups comprise at least one primary or secondary amine.

5 . The kit of claim 1 , wherein the polymer comprises dextran.

6 . The kit of claim 1 , wherein the dendrimer comprises a G5 PAMAM dendrimer.

7 . The kit of claim 1 , further comprising an applicator.

8 . The kit of claim 7 , wherein the applicator comprises a multi-compartment syringe.

9 . The kit of claim 8 , wherein the multi-compartment syringe comprises a mixing tip.

10 . The kit of claim 1 , wherein the polymer and the dendrimer are substituted with the one or more substituents capable of photoreversible dimerization.

11 . A drug delivery composition comprising:
a polymer component, wherein the polymer component comprises a polymer having three or more aldehyde groups; a dendrimer component, wherein the dendrimer component comprises a dendrimer having at least 2 branches with one or more surface groups; and at least one drug combined with at least one of the polymer component and the dendrimer component; wherein at least one of the polymer and the dendrimer is substituted with one or more substituents capable of photoreversible dimerization.

12 . The composition of claim 11 , wherein 100% of the surface groups comprise at least one primary or secondary amine.

13 . The composition of claim 11 , wherein less than 75% of the surface groups comprise at least one primary or secondary amine.

14 . The composition of claim 11 , wherein the polymer comprises dextran.

15 . The composition of claim 11 , wherein the dendrimer is a G5 PAMAM dendrimer.

16 . The composition of claim 11 , wherein the polymer and the dendrimer are substituted with the one or more substituents capable of photoreversible dimerization.

Assignees

• Massachusetts Inst Technology

Inventors

• Artzi Natalie
• Edelman Elazer R
• Kelmansky Regina
• Cervantes Marc Mier

Classifications

• A61L24/08

  Polysaccharides {(A61L24/043 takes precedence)} · CPC title

• A61L24/001

  Use of materials characterised by their function or physical properties · CPC title

• A61L27/50

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title

• A61K31/785 Primary

  Polymers containing nitrogen · CPC title

• A61K9/0019

  Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title