Injector Apparatus and Method for Drug Delivery

Patent metadata

Field	Value
Publication number	US-2018161202-A1
Application number	US-201715840965-A
Country	US
Kind code	A1
Filing date	Dec 13, 2017
Priority date	Aug 5, 2010
Publication date	Jun 14, 2018
Grant date	—

Abstract

Methods and apparatus provide a therapeutic fluid to devices implanted in the body, for example to containers of devices implanted in the eye of a patient. The methods and apparatus may comprise an injector to increase an amount of therapeutic agent injected into the device implanted in the eye, or a structure to receive the therapeutic fluid within the device implanted in the eye, or combinations thereof. The device implanted in the eye may comprise a reservoir chamber having a fluid with a density different than the therapeutic fluid, and the apparatus can be adapted to at least partially separate the implanted device fluid from therapeutic fluid within the reservoir chamber to increase and amount of therapeutic fluid placed in the reservoir chamber.

First claim

1 .- 127 . (canceled)

128 . A device for injecting a therapeutic agent into an ocular implant, the implant being at least partially implanted in an eye, the implant further providing at least a first resistance to outflow of therapeutic agent into the eye, the device comprising:
an injection lumen configured to provide a pathway for injecting the therapeutic agent into the ocular implant; an outlet lumen configured to provide a pathway through which a pre-existing fluid in the ocular implant exits the ocular implant; and a receiving chamber fluidly coupled to the outlet lumen, the receiving chamber configured to receive the pre-existing fluid that exits the ocular implant via the outlet lumen, wherein the receiving chamber provides a first fluid outflow resistance lower than the first resistance to outflow, and a second fluid outflow resistance greater than the first resistance to outflow; wherein injection of therapeutic agent into the ocular implant via the injection lumen causes the pre-existing fluid to exit the ocular implant into the receiving chamber via the outlet lumen and a second pre-existing fluid to displace from the receiving chamber; and further wherein, upon displacement from the receiving chamber of substantially all of the second pre-existing fluid, the second fluid outflow resistance provided by the receiving chamber causes a portion of the therapeutic agent to pass from the implant into the patient's eye upon injection of an additional amount of the therapeutic agent into the ocular implant.

129 . The device of claim 128 , wherein the implant is expandable in the eye from a first, collapsed configuration to a second, enlarged configuration.

130 . The device of claim 128 , wherein a first porous structure operatively coupled to the receiving chamber provides the first fluid outflow resistance and the second fluid outflow resistance.

131 . The device of claim 130 , wherein the first porous structure operatively coupled to the receiving chamber has the first fluid outflow resistance to gas outflow and the second fluid outflow resistance to liquid outflow.

132 . The device of claim 130 , wherein the implant comprises a second porous structure that provides the first resistance to outflow.

133 . The device of claim 132 , wherein the first fluid outflow resistance of the first porous structure of the receiving chamber is less than the first resistance provided by the second porous structure of the implant, and the second fluid outflow resistance of the first porous structure of the receiving chamber is greater than the first resistance provided by the second portion structure of the implant.

134 . The device of claim 128 , wherein the second pre-existing fluid is a gas.

135 . The device of claim 134 , wherein the gas is air.

136 . The device of claim 134 , wherein the gas is air under vacuum.

137 . The device of claim 128 , wherein the second pre-existing fluid is displaced from the receiving chamber via a vent.

138 . The device of claim 128 , wherein the second pre-existing fluid is displaced from the receiving chamber via a valve.

139 . The device of claim 128 , wherein the injection lumen and outlet lumen are concentrically positioned relative to one another.

140 . The device of claim 139 , wherein the outlet lumen surrounds the injection lumen along at least a portion of a length of the injection lumen.

141 . The device of claim 128 , wherein the injection lumen has a first opening out from the injection lumen and the outlet lumen has a second opening into the outlet lumen, wherein the injection lumen is longer than the outlet lumen such that the first opening from the injection lumen is located distal to the second opening into the outlet lumen.

142 . The device of claim 128 , further comprising a hub configured to removably receive a syringe that is configured to fluidly couple to the injection lumen.

143 . The device of claim 128 , further comprising a needle that defines the injection lumen.

144 . The device of claim 143 , further comprising a sheath at least partially over the needle so as to form the outlet lumen between an inner surface of the sheath and an outer surface of the needle.

145 . The device of claim 144 , wherein a distal tip of the sheath tapers such that at least a portion of the distal tip of the sheath contacts an outer surface of the needle.

146 . The device of claim 144 , wherein the sheath forms a first opening through which the pre-existing fluid exits the ocular implant into the outlet lumen.

147 . The device of claim 146 , wherein the first opening is located between a distal-most end of the sheath and an outer surface of the needle.

148 . The device of claim 147 , wherein a second opening is located at an end of the needle permitting the therapeutic agent to pass from the injection lumen into the ocular implant.

149 . The device of claim 148 , wherein the second opening is located distal to the first opening.

150 . The device of claim 148 , wherein the first opening and the second opening are in a fixed position relative to one another.

Assignees

• Forsight Vision4 Inc

Inventors

• De Juan Jr Eugene
• Alster Yair
• Farinas Kathleen Cogan
• Macfarlane K Angela
• Reich Cary J
• Campbell Randolph E
• Doud Darren
• Erickson Signe
• Barrett Mike
• Batten David
• Skieller Christina
• Stine Greg

Classifications

• A61M39/0247

  Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body (peritoneal dialysis catheters A61M1/285; tracheostomy devices A61M16/0465; measuring pressure within the body A61B5/03; colostomy devices A61F5/445; gastrotomy feeding tubes A61J15/0015; means for fixing a feeding tube outside of the body A61J15/0053) · CPC title

• A61F9/0017 Primary

  implantable in, or in contact with, the eye, e.g. ocular inserts · CPC title

• A61M5/31

  Details · CPC title

• A61M2039/027

  having a particular valve, seal or septum · CPC title

• A61M2039/0276

  for introducing or removing fluids into or out of the body · CPC title