Engineered microbe-targeting molecules and uses thereof
US-2017362307-A1 · Dec 21, 2017 · US
Modified lectin derived from wisteria floribunda
US2018134756A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2018134756-A1 |
| Application number | US-201715706144-A |
| Country | US |
| Kind code | A1 |
| Filing date | Sep 15, 2017 |
| Priority date | Dec 21, 2012 |
| Publication date | May 17, 2018 |
| Grant date | — |
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Abstract
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A Wisteria floribunda monomeric lectin polypeptide is provided. The Wisteria floribunda monomeric lectin polypeptide includes any one of the amino acid sequences selected from the group consisting of: (1) the amino acid sequence represented by SEQ ID NO: 2; (2) the amino acid sequence defined in (1) above, except that one to 20 amino acids at positions other than Cys272 position is/are deleted, substituted, inserted, or added; and (3) the amino acid sequence defined in (1) or (2) above, further having an N-terminus deletion of one to 30 amino acids, in which Cys272 is alkylated, and the polypeptide is capable of specifically binding to a GalNAc terminal sugar chain.
First claim
Opening claim text (preview).
What is claimed is: 1 . A Wisteria floribunda monomeric lectin polypeptide comprising any one of the amino acid sequences selected from the group consisting of: (1) the amino acid sequence represented by SEQ ID NO: 2; (2) the amino acid sequence defined in (1) above, except that one to 20 amino acids at positions other than Cys272 position is/are deleted, substituted, inserted, or added; and (3) the amino acid sequence defined in (1) or (2) above, further having an N-terminus deletion of one to 30 amino acids, wherein Cys272 is alkylated, and wherein the polypeptide is capable of specifically binding to a GalNAc terminal sugar chain. 2 . A reagent composition for detecting a GalNAc terminal sugar chain marker, wherein the reagent composition comprises the polypeptide of claim 1 . 3 . A method for enhancing specificity of GalNAc terminal sugar-chain binding activity of a Wisteria floribunda lectin polypeptide composition, the method comprising: reducing the polypeptide composition having Gal/GalNAc terminal sugar-chain binding activity and comprising a Wisteria floribunda monomeric lectin polypeptide and a dimer thereof, the polypeptide comprising any one of the amino acid sequences selected from the group consisting of: (1) the amino acid sequence represented by SEQ ID NO: 2; (2) the amino acid sequence defined in (1) above, except that one to 20 amino acids at positions other than Cys272 position is/are deleted, substituted, inserted, or added; and (3) the amino acid sequence defined in (1) or (2) above, further having an N-terminus deletion of one to 30amino acids.
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Classifications
Lectins, e.g. concanavalin, phytohaemagglutinin · CPC title
- C07K14/42Primary
Lectins, e.g. concanavalin, phytohaemagglutinin · CPC title
for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites · CPC title
Assays, e.g. immunoassays or enzyme assays, involving carbohydrates · CPC title
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- What does patent US2018134756A1 cover?
- A Wisteria floribunda monomeric lectin polypeptide is provided. The Wisteria floribunda monomeric lectin polypeptide includes any one of the amino acid sequences selected from the group consisting of: (1) the amino acid sequence represented by SEQ ID NO: 2; (2) the amino acid sequence defined in (1) above, except that one to 20 amino acids at positions other than Cys272 position is/are dele…
- Who is the assignee on this patent?
- Aist
- What technology area does this patent fall under?
- Primary CPC classification C07K14/42. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Thu May 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).