Composition

Patent metadata

Field	Value
Publication number	US-2018133358-A1
Application number	US-201615576139-A
Country	US
Kind code	A1
Filing date	May 26, 2016
Priority date	May 27, 2015
Publication date	May 17, 2018
Grant date	—

Abstract

A polyurethane foam wound dressing, the foam integrally comprising an oxidoreductase enzyme and a substrate for the enzyme. The foam is produced by mixing a polyurethane polymer, water, an oxidoreductase enzyme and substrate for the enzyme and drying the resulting product.

First claim

1 . A polyurethane foam wound dressing, the foam integrally comprising an oxidoreductase enzyme and a substrate for the oxidoreductase enzyme.

2 . The foam wound dressing of claim 1 , wherein
the oxidoreductase enzyme is glucose oxidase and the substrate is glucose, the oxidoreductase enzyme is fructose oxidase and the substrate is fructose, the oxidoreductase enzyme is hexose oxidase and the substrate is a hexose sugar, the oxidoreductase enzyme is cholesterol oxidase and the substrate is cholesterol, the oxidoreductase enzyme is galactose oxidase and the substrate is galactose, the oxidoreductase enzyme is pyranose oxidase and the substrate is pyranose, the oxidoreductase enzyme is choline oxidase and the substrate is choline, the oxidoreductase enzyme is pyruvate oxidase and the substrate is pyruvate or the oxidoreductase enzyme is glycollate oxidase and the substrate is glycollate.

3 . The foam wound dressing of claim 1 , wherein the foam has a density of at least 0.28 g/cm 3 and comprises at least 0.1 mg enzyme per gram of foam, and at least 1% (w/w) of substrate.

4 . The foam wound dressing of claim 1 , wherein the foam is produced by mixing a polyurethane polymer, water, an oxidoreductase enzyme and a substrate for the oxidoreductase enzyme to produce a resulting product; and drying the resulting product.

5 . The foam wound dressing of claim 4 , wherein a monohydric alcohol and/or a rubber is added when producing the foam.

6 . A method of producing a polyurethane foam wound dressing comprising
mixing a polyurethane polymer, water, an oxidoreductase enzyme and a substrate for the oxidoreductase enzyme to produce a resulting product; and drying the resulting product.

7 . The method of claim 6 , wherein a monohydric alcohol is added when producing the foam.

8 . The method of claim 6 , wherein the polyurethane polymer is an isocyanate-capped prepolymer.

9 . The method of claim 7 , wherein the monohydric alcohol is methanol.

10 . The method of claim 6 , wherein a rubber is added when producing the foam.

11 . The method of claim 6 , wherein
the oxidoreductase enzyme is glucose oxidase and the substrate is glucose, the oxidoreductase enzyme is fructose oxidase and the substrate is fructose, the oxidoreductase enzyme is hexose oxidase and the substrate is a hexose sugar, the oxidoreductase enzyme is cholesterol oxidase and the substrate is cholesterol, the oxidoreductase enzyme is galactose oxidase and the substrate is galactose, the oxidoreductase enzyme is pyranose oxidase and the substrate is pyranose, the oxidoreductase enzyme is choline oxidase and the substrate is choline, the oxidoreductase enzyme is pyruvate oxidase and the substrate is pyruvate or the oxidoreductase enzyme is glycollate oxidase and the substrate is glycollate.

12 . The method of claim 6 , wherein the drying is carried out at over 50° C. and below 100° C., including between 60° C. to 80° C.

13 . A polyurethane foam wound dressing obtained or obtainable according to the method of claim 6 .

14 . A polyurethane foam wound dressing, the foam integrally comprising glucose and glucose oxidase, wherein the foam is produced by mixing an isocyanate-capped prepolymer, water, methanol and an aqueous acrylic polymer emulsion to form a mixture and drying the mixture at between 60° C. and 100° C. for at least 5 minutes.

15 . (canceled)

16 . A method of treating a wound comprising applying the polyurethane foam wound dressing of claim 1 or to a wound site.

17 . The foam wound dressing of claim 3 , comprising 0.1 mg to 1 mg enzyme per gram of foam.

18 . The foam wound dressing of claim 3 , comprising 5-20% of substrate.

19 . The method of claim 10 , wherein the rubber is an aqueous acrylic polymer emulsion.

20 . The method of claim 12 , herein the is carried out between 60° C. to 80° C.

Assignees

• Kci Usa Inc

Inventors

• Cullen Breda Mary
• Waite Alexander
• Silcock Derek

Classifications

• A61L15/26

  Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof {(A61L15/225 takes precedence)} · CPC title

• A61L15/38

  containing enzymes · CPC title

• A61L15/425 Primary

  Porous materials, e.g. foams or sponges · CPC title