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Method of screening an agent for inhibiting recurrence or metastasis of breast cancer
US2018128815A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2018128815-A1 |
| Application number | US-201414412081-A |
| Country | US |
| Kind code | A1 |
| Filing date | Oct 2, 2014 |
| Priority date | Mar 31, 2014 |
| Publication date | May 10, 2018 |
| Grant date | — |
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- Title
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Abstract
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The present invention relates to a method of screening preparations for inhibiting metastasis or recurrence of breast cancer using the change in the expression level of marker genes for breast cancer stem cells, wherein their expression levels are changed by the treatment with a Wnt signaling inhibitor. The method of the present invention enables to screen preparations for preventing or treating the metastasis or recurrence of breast cancer with superior accuracy and thus the method can be widely used for the effective treatment of breast cancer.
First claim
Opening claim text (preview).
1 . A method of screening an agent for preventing or treating recurrence or metastasis of breast cancer, comprising: (a) treating cancer stem cells derived from breast cancer with a candidate compound expected to be capable of preventing or treating recurrence or metastasis of breast cancer; (b) measuring the level of mRNA or protein encoded by at least one gene selected from the group consisting of Insulin-like growth factor 1 (IGF1), Inhibitor of DNA binding 2 (Id2), Matrix Metalloproteinase-2 (MMP2), Matrix Metalloproteinase-9 (MMP9) and Wingless-type MMTV Integration site family, member 5A (Wnt5a) in the cells treated with the candidate compound; and (c) selecting the candidate compound capable of reducing the level of mRNA or a protein encoded by the gene compared to that of a negative control group not treated with the candidate compound. 2 . The method of claim 1 , wherein the candidate compound is a signaling inhibitor inhibiting Wnt signaling.
Assignees
Inventors
Classifications
of the breast · CPC title
specific for metastasis · CPC title
Physics · mapped topic
Methods for determination or identification of nucleic acids involving differential detection · CPC title
- C12Q1/6886Primary
for cancer (immunoassay for cancer G01N33/575) · CPC title
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- What does patent US2018128815A1 cover?
- The present invention relates to a method of screening preparations for inhibiting metastasis or recurrence of breast cancer using the change in the expression level of marker genes for breast cancer stem cells, wherein their expression levels are changed by the treatment with a Wnt signaling inhibitor. The method of the present invention enables to screen preparations for preventing or treatin…
- Who is the assignee on this patent?
- Univ Gachon Ind Acad Coop Found, Gil Medical Ct
- What technology area does this patent fall under?
- Primary CPC classification C12Q1/6886. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Thu May 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).