Two-phase calibration of a neuroprosthetic system

Patent metadata

Field	Value
Publication number	US-2018117318-A1
Application number	US-201615340728-A
Country	US
Kind code	A1
Filing date	Nov 1, 2016
Priority date	Nov 1, 2016
Publication date	May 3, 2018
Grant date	—

Abstract

Methods and systems are provided for triggering electrical stimulation of a spinal cord during execution of a motor event. In one example, a method comprises monitoring motor cortex activity while execution of a desired motor movement is attempted during a first mode where one or more nerve fibers are not stimulated, and during a second mode where the one or more nerve fibers are stimulated. Delivery timing of electrical stimulation may be closed-loop controlled based on current motor cortex activity and the motor cortex activity recorded previously during both the first and second modes.

First claim

1 . A method comprising:
during a first mode, monitoring motor events and motor cortex activity while not stimulating one or more nerve fibers; during a second mode:
stimulating the one or more nerve fibers; and
monitoring motor events and motor cortex activity during and after stimulating the one or more nerve fibers; and
generating a motor movement command model that predicts motor movement commands during attempted execution of a motor event based on the motor cortex activity monitored during both the first and second modes.

2 . The method of claim 1 , wherein the second mode is executed after the first mode.

3 . The method of claim 1 , wherein the motor event is performed at least once during each of the first and second modes.

4 . The method of claim 3 further comprising, synchronizing the monitored motor cortex activity with the motor events, and where the motor movement commands comprise motor cortex generated commands for executing the motor event.

5 . The method of claim 3 , wherein during the first mode, motor cortex activity is monitored for a first selected number of repetitions of the motor event, and then during the second mode, motor cortex activity is monitored for a second selected number of repetitions of the motor event.

6 . The method of claim 1 , wherein during the first mode the method further comprises, generating an initial motor movement command model that predicts motor movement commands from motor cortex activity during the motor event while the one or more nerve fibers are not stimulated based on the monitored motor cortex activity from the first mode, and where the generating the motor movement command model comprises modifying the initial motor movement command model generated during the first mode, based on the motor cortex activity monitored during the second mode.

7 . The method of claim 1 further comprising, during the second mode, identifying a neural response signal based on the motor cortex activity monitored during and after the stimulating the one or more nerve fibers, the neural response signal generated in response to the stimulating of the one or more nerve fibers.

8 . The method of claim 7 , wherein the stimulating the one or more nerve fibers is performed only after the neural response signal from a most recent stimulation of the one or more nerve fibers has terminated.

9 . The method of claim 1 , wherein the stimulating the one or more nerve fibers comprises electrically pulsing the one or more nerve fibers.

10 . The method of claim 1 , wherein the stimulating the one or more nerve fibers during the second mode comprises stimulating the one or more nerve fibers at least twice.

11 . The method of claim 1 , wherein the stimulating the one or more nerve fibers comprises stimulating the one or more nerve fibers at a desired instance during execution of a motor event, where the desired instance is determined based on neural activity.

12 . A method comprising:
while monitoring motor cortex activity during attempted execution of a desired motor movement, electrically stimulating a nerve fiber at a desired instance following a motor movement command; and while inducing execution of the desired motor movement, electrically stimulating the nerve fiber under closed-loop control based on current motor cortex activity and the monitored motor cortex activity.

13 . The method of claim 12 , wherein the motor movement command is generated by a motor cortex and commands for execution of the desired motor movement.

14 . The method of claim 12 , wherein the desired motor movement comprises stepping, and where inducing execution of the stepping comprises assisting the stepping via one or more of a physiotherapists or other caretaker, walker, crutches, cane, gait trainer, prosthesis, exoskeleton, treadmill, and body weight support system with a harness.

15 . The method of claim 12 , wherein the electrically stimulating the nerve fiber under closed-loop control comprises determining when to deliver the electrical stimulation based on the output of a motor movement command model using processed current motor cortex activity that is indicative of current neural activity.

16 . The method of claim 12 , further comprising calibrating a motor movement command model based on previously recorded and synchronized motor events and neural activity, the motor movement command model comprising a prediction of motor movement commands from the current neural activity that will occur while inducing execution of the desired motor movement.

17 . The method of claim 12 , wherein the electrically stimulating the nerve fiber under closed-loop control comprises determining a likelihood that the desired instance is occurring, that likelihood being the likelihood that motor movement command is formed, as calculated by the motor movement command model from the current neural activity, and initiating the electrical stimulation in response to the likelihood increasing above a threshold.

18 . A neuroprosthetic system comprising:
a neurosensor for monitoring neural activity; an electrical stimulator for delivering electrical stimulation to one or more nerve fibers; and a controller in communication with the neurosensor and electrical stimulator, the controller including computer readable instruction stored in non-transitory memory for:
triggering electrical stimulation events based on neural activity data received from the neurosensor;
calibrating a motor movement command model based on previously recorded synchronized motor events and neural activity in the presence and absence of stimulation; and
adjusting the stimulation events based on the output of the motor movement command model.

19 . The neuroprosthetic system of claim 18 , wherein the neurosensor comprises one or more of an electrode array, EEG, iEEG, fMRI, electrocorticogram, NIRS, glass pipette electrode, one or two photon excitation imaging with calcium indicators, neural activity recorded using voltage sensitive dyes, neural dust, tetrode array, wire electrodes, and patch clamping.

20 . A method for closed-loop operating a stimulator of a neuroprosthetic, the method comprising:
determining when to activate the stimulator to deliver stimulation based on output of the motor movement command model calculated from the current neural activity received from a neurosensor, and a motor movement command model that accounts for effects of stimulation on the neural activity; and delivering the stimulation when a likelihood of a desired instance to stimulate increases above a threshold, as calculated by the motor movement command model from the current neural activity.

21 . The method of claim 20 , wherein the desired instance to stimulate is during, or immediately after generation of a motor movement command by a motor cortex, the motor movement command comprising a command for execution of a desired motor movement

Assignees

• Ecole Polytechnique Fed Lausanne Epfl

Inventors

• Milekovic Tomislav
• Capogrosso Marco
• Courtine Gregoire
• Martin Moraud Eduardo
• Wagner Fabien
• Gandar Jerome

Classifications

• A61N1/36146

  specified by the stimulation parameters · CPC title

• A61N1/36062 Primary

  Spinal stimulation · CPC title

• A61B5/0036

  including treatment, e.g., using an implantable medical device, ablating, ventilating · CPC title

• A61N1/0551

  Spinal or peripheral nerve electrodes · CPC title

• A61F2/54

  Artificial arms or hands or parts thereof · CPC title