System and method for imaging nanodiamonds as dynamic nuclear polarization agent

Patent metadata

Field	Value
Publication number	US-2018113185-A1
Application number	US-201615562551-A
Country	US
Kind code	A1
Filing date	Apr 1, 2016
Priority date	Apr 1, 2015
Publication date	Apr 26, 2018
Grant date	—

Abstract

A system and method performing a medical imaging process includes arranging a subject to receive solution comprising nanodiamonds, performing an MRI imaging process to acquire data from the subject, and reconstructing the data to generate a report indicating a spatial distribution of nanodiamonds in the subject.

First claim

1 . A magnetic resonance imaging (MRI) system, comprising:
a magnet system configured to generate a static magnetic field about at least a region of interest (ROI) of a subject arranged in the MRI system; at least one gradient coil configured to establish at least one magnetic gradient field with respect to the static magnetic field; a radio frequency (RF) system configured to deliver excitation pulses to the subject; a computer system programmed to:
control the at least one gradient coil and the RF system to perform a MRI pulse sequence;
acquire data corresponding to signals from the subject having received solution comprising nanodiamonds; and
reconstruct, from the data, at least one anatomical image of the subject and spatially distributed nanodiamonds within the subject relative to the anatomical image.

2 . The system of claim 1 , further comprising a probe comprising a electron spin resonance (ESR) resonator tuned at a first frequency and a solenoid coil resonator tuned at a second frequency lower than the first frequency.

3 . The system of claim 1 , wherein the static magnetic field includes a low-field static magnetic field less than 10 mT.

4 . The system of claim 1 , wherein the computer system is programmed to perform at least one embedded electron paramagnetic resonance (EPR) pulse to turn on dynamic nuclear polarization (DNP) contrast caused by the solution comprising the nanodiamonds.

5 . The system of claim 4 , wherein the computer system is further programmed to deactivate the DNP contrast by turning off the at least one embedded EPR pulse.

6 . The system of claim 5 , wherein the computer system is further programmed to reactivate the DNP contrast by turning on the at least one embedded EPR pulse.

7 . The system of claim 4 , wherein the computer system is programmed to obtain DNP data when the at least one EPR pulse is performed and reconstruct at least one DNP image from the DNP data.

8 . The system of claim 1 , wherein the computer system is programmed to obtain at least one difference image by taking a difference between the at least one anatomical image and the at least one DNP image.

9 . The system of claim 1 , further comprising a liquid processor that prepares the solution comprising nanodiamonds using power probe sonication to disaggregate nanodiamonds clusters.

10 . A method for performing a medical imaging process, comprising:
arranging a subject to receive solution comprising nanodiamonds; performing a magnetic resonance imaging (MRI) process to acquire a first data from the subject; performing an Overhauser-enhanced magnetic resonance imaging (OMRI) process to acquire a second data from the subject; and reconstructing the first and second data to generate a report indicating a spatial distribution of the nanodiamonds in the subject.

11 . The method of claim 9 , further comprising targeting the solution comprising nanodlamonds to bind to a particular organ or a tissue of interest.

12 . The method of claim 11 , further comprising imaging at least one of fibrin, collagen, arterial or venous plaques, or tumor cells using the targeted solution.

13 . The method of claim 10 , wherein the report indicates at least one of hyper-acute or mild blood brain barrier (BBB) disruption.

14 . The method of claim 10 , further comprising at least one of the following:
developing a chemoprevention strategy using the report; and using the report to predict or prevent hemorrhagic transformation.

15 . The method of claim 10 , further comprising delivering therapies directed to alleviate nanodiamonds-mediated cell damage and monitoring an impact of the therapies using the report.

16 . The method of claim 10 , further comprising performing at least one EPR pulse to turn on dynamic nuclear polarization (DNP) contrast caused by the solution comprising the nanodiamonds.

17 . The method of claim 16 , further comprising deactivating the DNP contrast by turning off the at least one EPR pulse.

18 . The method of claim 17 , further comprising reactivating the DNP contrast by turning on the at least one EPR pulse.

19 . The method of claim 10 , further comprising:
reconstructing, from the first data, at least one anatomical image of the subject and spatially distributed nanodlamonds within the subject relative to the anatomical image; reconstructing, from the second data, at least one DNP image of the subject and spatially distributed nanodiamonds within the subject relative to the anatomical image; and obtaining at least one difference image by taking a difference between the at least one anatomical image and the at least one DNP image.

20 . A magnetic resonance imaging (MRI) system, comprising:
a magnet system configured to generate a static magnetic field about at least a region of interest (ROI) of a subject arranged in the MRI system; at least one gradient coil configured to establish at least one magnetic gradient field with respect to the static magnetic field; a radio frequency (RF) system configured to deliver excitation pulses to the subject having received solution comprising nanodiamonds, wherein the excitation pulses comprises at least one embedded electron paramagnetic resonance (EPR) pulse; and a controller configured to manipulate dynamic nuclear polarization (DNP) contrast caused by the nanodiamonds by turning on or turning off the at least one embedded electron paramagnetic resonance (EPR) pulse.

Assignees

• Massachusetts Gen Hospital

Inventors

• Rosen Matthew S
• Sarracanie Mathieu
• Zhang Huiliang
• Riley David
• Walsworth Ronald L
• Waddington David

Classifications

• A61B5/055

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title

• G01R33/282

  Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent · CPC title

• G01R33/5601 Primary

  involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent · CPC title

• A61K49/1818

  particles, e.g. uncoated or non-functionalised microparticles or nanoparticles · CPC title

• G01R33/5614

  using a fully balanced steady-state free precession [bSSFP] pulse sequence, e.g. trueFISP · CPC title