Dry sterilizable bag and clamp for storing liquid and frozen media and dispensing

Patent metadata

Field	Value
Publication number	US-2018104147-A1
Application number	US-201615564864-A
Country	US
Kind code	A1
Filing date	Apr 8, 2016
Priority date	Apr 10, 2015
Publication date	Apr 19, 2018
Grant date	—

Abstract

A single-use bag ( 32 ) and dispensing system ( 30 ) for storage of liquid or frozen media and for dispensing the media are disclosed. A single-use bag ( 32 ) is composed of materials that can withstand the temperatures required for dry heat sterilization and, further, includes specialized clamps ( 40, 140 ) that accommodate the materials and construction techniques necessary for constructing the single-use bag ( 32 ) for restriction and isolation of flow from the single-use bag ( 32 ). The single-use bag ( 32 ) includes an inner film ( 76 ) defining a bag interior ( 52 ) and an outer film ( 78 ) overlying the inner film ( 76 ), the inner film ( 76 ) and the outer film ( 78 ) being heat bonded together, the inner film ( 76 ) being composed of perfluoroalkoxy alkane (PFA) and the outer film ( 78 ) being composed of polytetrafluoroethylene (PTFE), the single-use bag ( 32 ) defining at least one exit port ( 62 ) on a bottom edge ( 48 ) thereof; and at least one closeable exit passage ( 34 ) depending from the bottom edge ( 48 ) of the single-use bag ( 32 ), each of the at least one exit passage ( 34 ) being coupled to a respective one of the at least one exit port ( 62 ), the at least one exit passage ( 34 ) being in fluid communication with the bag interior ( 52 ).

First claim

1 . A storage and dispensing system capable of storing a liquid or frozen medium and dispensing the medium, the system comprising:
a single-use bag including an inner film defining a bag interior and an outer film overlying the inner film, the inner film and the outer film being heat bonded together, the inner film being composed of perfluoroalkoxy alkane and the outer film being composed of polytetrafluoroethylene, the single-use bag defining at least one exit port on a bottom edge thereof; and at least one closeable exit passage depending from the bottom edge of the single-use bag, each of the at least one exit passage being coupled to a respective one of the at least one exit port, the at least one exit passage being in fluid communication with the bag interior.

2 . The storage and dispensing system of claim 1 , wherein each of the at least one exit passage is unitary with the single-use bag.

3 . The storage and dispensing system of claim 1 , further comprising a clamp having opposed jaws, each of the opposed jaws including a compliant member disposed on a rigid sub structure, wherein:
the compliant members of the opposed jaws are capable of engaging each other along a line of contact when the opposed jaws are in a closed position; and the clamp is configured to engage one of the at least one exit passage for restricting flow through the exit passage.

4 . The storage and dispensing system of claim 3 , wherein the opposed jaws are pivotally connected.

5 . The storage and dispensing system of claim 3 , wherein the clamp comprises a ratchet and pawl for locking the opposed jaws in a fixed relationship when the clamp is occupied by the exit passage.

6 . The storage and dispensing system of claim 3 , wherein the compliant members have a hardness in a range of Shore A 10 to Shore A 60.

7 . The storage and dispensing system of claim 3 , wherein the compliant members have a thickness in a direction of closing the opposed jaws, the thickness being in a range of about 1 mm to about 5 mm.

8 . The storage and dispensing system of claim 6 , wherein the compliant members each comprise a partial sleeve configured to fit over a respective one of the rigid sub structures.

9 . The storage and dispensing system of claim 7 , wherein the compliant members each comprise a partial sleeve configured to fit over a respective one of the rigid sub structures.

10 . The storage and dispensing system of claim 6 , wherein the compliant members are overmolded onto the rigid sub structures.

11 . The storage and dispensing system of claim 7 , wherein the compliant members are overmolded onto the rigid sub structures.

12 . The storage and dispensing system of claim 1 , wherein the inner film and the outer film are laminated together.

13 . The storage and dispensing system of claim 1 , further comprising at least one fitting, wherein the at least one exit passage is configured to receive the at least one fitting and places the at least one fitting in fluid communication with the bag interior.

14 . The storage and dispensing system of claim 13 , wherein the at least one fitting is a hose barb, a luer fitting, a quick connect fitting, or a flare-type fitting.

15 . The storage and dispensing system of claim 1 , further comprising at least one tubing stub and at least one annular film depending from the at least one tubing stub, wherein the at least one exit passage is configured to receive the at least one tubing stub and places the at least one tubing stub and annular film in fluid communication with the bag interior.

16 - 21 . (canceled)

22 . The storage and dispensing system of claim 1 , wherein the single use bag has a volume of about 500 mL, about 1 L about 2 L, about 5 L, about 10 L, or about 20 L.

Assignees

• Entegris Inc

Inventors

• Ware Donald D
• Koland Amy
• Brosch Brenna
• Leys John A
• Johnson Michael W
• Schleicher Michael J

Classifications

• A61J1/10

  Bag-type containers · CPC title

• A61J1/1487

  with friction fit, e.g. connecting tubes directly to a protruding port · CPC title

• A61J1/1468

  Containers characterised by specific material properties · CPC title

• A61J1/1481

  with connection retaining means, e.g. thread or snap-fit · CPC title

• A61J1/1462

  Containers with provisions for hanging, e.g. integral adaptations of the container (accessories for hanging the container A61M5/1414) · CPC title