Enhancing Bond Strength Of Medical Devices

Patent metadata

Field	Value
Publication number	US-2018086902-A1
Application number	US-201715711646-A
Country	US
Kind code	A1
Filing date	Sep 21, 2017
Priority date	Sep 26, 2016
Publication date	Mar 29, 2018
Grant date	—

Abstract

Components of medical devices include polyethylene-poly(ethylene oxide) amphiphilic graft copolymers (PE-g-PEO) in their base polymer formulations. The base polymeric formulations comprise at least a polymer or co-polymer of ethylene. These components are suitable for solvent-bonding with other components and enhance bond strength of the medical devices.

First claim

What is claimed is:

1 . A tubing for a medical device formed from a blend comprising:
a base polymeric formulation comprising at least a polymer or co-polymer of ethylene or propylene and excluding free poly(ethylene oxide); and an additive comprising a polyethylene-poly(ethylene oxide) amphiphilic graft copolymer (PE-g-PEO); the PE-g-PEO being present in the blend in an amount in the range of about 0.01 to about 5.0% by weight of the blend.

2 . The tubing of claim 1 , wherein the PE-g-PEO is according to Formula (I):

wherein R is hydrogen, alkyl, substituted alkyl, vinylic substituted alkyl, hydrocarbyl, substituted hydrocarbyl, or vinylic substituted hydrocarbyl group; the molar value of m is in the range from 2 to 40 mole percent; the molar value of n is in the range from 60 to 98 mole percent; and p is in the range from 5 to 500 ethylene oxide units.

3 . The tubing of claim 1 , wherein the base polymeric formulation comprises polyethylene, polypropylene, a polyethylene-polypropylene co-polymer, a polyethylene- and/or polypropylene-containing thermoplastic elastomer (TPE), or combinations thereof.

4 . The tubing of claim 3 , wherein the base polymeric formulation comprises a co-polymer of polyethylene and polypropylene.

5 . The tubing of claim 3 , wherein the polyethylene-and/or polypropylene-containing thermoplastic elastomer (TPE) comprises at least 60 mol % total polyethylene and/or polypropylene.

6 . The tubing of claim 1 , wherein the PE-g-PEO is a product of ethylene oxide ring-opening polymerization of an ethylene vinyl acetate copolymer having from 10 to 40 weight percent of vinyl acetate.

7 . The tubing of claim 1 , wherein the PE-g-PEO has a dispersity index in the range of 2 to 10.

8 . A medical device comprising:
a tubing comprising a polymeric blend comprising a base polymeric formulation comprising at least a polymer or co-polymer of ethylene or propylene and excluding free poly(ethylene oxide), and an additive comprising a polyethylene-poly(ethylene oxide) amphiphilic graft copolymer (PE-g-PEO) according to Formula (I):

wherein R is hydrogen, alkyl, substituted alkyl, vinylic substituted alkyl, hydrocarbyl, substituted hydrocarbyl, or vinylic substituted hydrocarbyl group;
the molar value of m is in the range from 2 to 40 mole percent; the molar value of n is in the range from 60 to 98 mole percent; and p is in the range from 5 to 500 ethylene oxide units;
wherein the PE-g-PEO is present in the blend in an amount in the range of about 0.01 to about 5.0% by weight of the blend; and
a connector bonded to the tubing;
wherein the PE-g-PEO is effective to enhance bonding of the tubing to a connector.

9 . The medical device of claim 8 , wherein the base polymeric formulation comprises polyethylene, polypropylene, a polyethylene-polypropylene co-polymer, a polyethylene- and/or polypropylene-containing thermoplastic elastomer (TPE), or combinations thereof.

10 . The medical device of claim 8 , wherein the base polymeric formulation comprises a co-polymer of polyethylene and polypropylene.

11 . The medical device of claim 8 , wherein the polyethylene-and/or polypropylene-containing thermoplastic elastomer (TPE) comprises at least 60 mol % polyethylene and/or polypropylene.

12 . The medical device of claim 8 , wherein the PE-g-PEO is a product of ethylene oxide ring-opening polymerization of an ethylene vinyl acetate copolymer having from 10 to 40 weight percent of vinyl acetate.

13 . The medical device of claim 8 , wherein the connector comprises a polar material.

14 . The medical device of claim 13 , wherein the polar material selected from the group consisting of: poly(methyl methacrylate) (PMMA), styrene maleic anhydride (SMA), polycarbonate (PC), and methyl methacrylate-acrylonitrile-butadiene-styrene (MABS).

15 . The medical device of claim 8 , wherein the connector is solvent-bonded to the tubing.

16 . A method of making a medical device comprising:
obtaining a polyethylene-poly(ethylene oxide) amphiphilic graft copolymer (PE-g-PEO); combining the PE-g-PEO with a base polymeric formulation comprising at least a polymer or co-polymer of ethylene or propylene and excluding free poly(ethylene oxide) to form a blend, the PE-g-PEO being present in the blend in an amount in the range of about 0.01 to about 5.0% by weight of the blend; forming a tubing from the blend; and bonding the tubing to a connector in the presence of a solvent to form the medical device; wherein the PE-g-PEO is effective to enhance bonding of the tubing to a connector.

17 . The method of claim 16 , wherein ethylene oxide ring-opening polymerization of an ethylene vinyl acetate copolymer having from 10 to 40 weight percent of vinyl acetate is used to form the PE-g-PEO, which is according to Formula (I):

wherein R is hydrogen, alkyl, substituted alkyl, vinylic substituted alkyl, hydrocarbyl, substituted hydrocarbyl, or vinylic substituted hydrocarbyl group; the molar value of m is in the range from 2 to 40 mole percent; the molar value of n is in the range from 60 to 98 mole percent; and p is in the range from 5 to 500 ethylene oxide units.

18 . The method of claim 16 , wherein the base polymeric formulation comprises polyethylene, polypropylene, a polyethylene-polypropylene co-polymer, a polyethylene- and/or polypropylene-containing thermoplastic elastomer (TPE), or combinations thereof.

19 . The method of claim 16 , wherein the base polymeric formulation comprises a co-polymer of polyethylene and polypropylene.

20 . The method of claim 16 , wherein the polyethylene-and/or polypropylene-containing thermoplastic elastomer (TPE) comprises at least 60 mol % polyethylene and/or polypropylene.

Assignees

• Becton Dickinson Co

Inventors

• Zhang Jianbin
• Hermel-Davidock Theresa
• Coughlin Edward Bryan
• Datashvili Tea

Classifications

• C08L23/06 Primary

  Polyethylene · CPC title

• C08L2207/066

  LDPE (radical process) · CPC title

• C08L2203/18

  used for pipes · CPC title

• F16L13/007

  specially adapted for joining pipes of dissimilar materials {(joints between metal and plastic pipes F16L47/24)} · CPC title

• A61L29/049 Primary

  Mixtures of macromolecular compounds · CPC title