Diagnosis system and method using photoacoustic/ultrasound contrast agent

Patent metadata

Field	Value
Publication number	US-2018078236-A1
Application number	US-201515560980-A
Country	US
Kind code	A1
Filing date	Oct 14, 2015
Priority date	Apr 15, 2015
Publication date	Mar 22, 2018
Grant date	—

Abstract

The present invention relates to a diagnosis system and method using a contrast agent used in photoacoustic image diagnosis and ultrasound image diagnosis. More particularly, the present invention relates to a diagnosis system and method using a photoacoustic/ultrasound contrast agent, the system and method discriminating and selectively detecting ultrasonic waves emitted from respective contrast agents by analyzing a correlation between a size of a contrast agent and a frequency of an ultrasonic wave emitted from the contrast agent, thereby obtaining a plurality of clear photoacoustic images.

First claim

1 . A diagnosis method using a photoacoustic/ultrasound contrast agent, the method comprising:
obtaining a photoacoustic image by considering a correlation between a size of a photoacoustic/ultrasound contrast agent and a frequency of an ultrasonic wave that is a photoacoustic signal emitted from the contrast agent.

2 . The diagnosis method of claim 1 , further comprising:
emitting, at a photoacoustic signal generation step, light to the photoacoustic/ultrasound contrast agent such that the ultrasonic wave having a particular frequency is emitted; and detecting, at a detection imaging step, the ultrasonic wave emitted at the photoacoustic signal generation step and imaging the ultrasonic wave, wherein at the detection imaging step, the frequency of the ultrasonic wave that varies depending on the size of the photoacoustic/ultrasound contrast agent is selectively detected and imaged.

3 . The diagnosis method of claim 2 , wherein at the photoacoustic signal generation step, a plurality of photoacoustic/ultrasound contrast agents having different sizes is used such that a plurality of ultrasonic waves having different frequencies is emitted, and
at the detection imaging step, the plurality of ultrasonic waves having the different frequencies is detected and imaged such that a plurality of photoacoustic images is obtained.

4 . The diagnosis method of claim 3 , wherein the plurality of photoacoustic/ultrasound contrast agents is injected into different parts in a body, and
at the detection imaging step, the plurality of photoacoustic images of the different parts is simultaneously obtained.

5 . The diagnosis method of claim 3 , wherein the plurality of photoacoustic/ultrasound contrast agents is injected into a same part in a body, and
at the detection imaging step, the plurality of photoacoustic images of the same part is obtained.

6 . The diagnosis method of claim 3 , wherein the plurality of photoacoustic/ultrasound contrast agents targets different biomarkers such that the plurality of photoacoustic images is obtained at the detection imaging step, whereby multi-imaging is performed.

7 . The diagnosis method of claim 6 , wherein each of the plurality of photoacoustic/ultrasound contrast agents includes a ligand that is conjugated to a surface thereof and targets a particular biomarker.

8 . The diagnosis method of claim 6 , wherein at the detection imaging step, the plurality of photoacoustic images has different colors.

9 . A diagnosis system using a photoacoustic/ultrasound contrast agent, the system obtaining a photoacoustic image by considering a correlation between a size of a photoacoustic/ultrasound contrast agent and a frequency of an ultrasonic wave that is a photoacoustic signal emitted from the contrast agent

10 . The diagnosis system of claim 9 , further comprising:
the photoacoustic/ultrasound contrast agent being injected into a body and being used as a photoacoustic and ultrasound contrast agent; a light emitting device emitting light to the photoacoustic/ultrasound contrast agent; and a detection imaging device detecting the ultrasonic wave, emitted from the photoacoustic/ultrasound contrast agent by absorbing the light of the light emitting device, and imaging the ultrasonic wave, wherein the detection imaging device selectively detects the frequency of the ultrasonic wave that varies depending on the size of the photoacoustic/ultrasound contrast agent so as to image the frequency.

11 . The diagnosis system of claim 10 , wherein the detection imaging device includes an ultrasound transducer detecting the ultrasonic wave emitted from the photoacoustic/ultrasound contrast agent, and
the ultrasound transducer has a detection frequency band containing the frequency of the ultrasonic wave emitted from a particular contrast agent.

12 . The diagnosis system of claim 11 , wherein a plurality of photoacoustic/ultrasound contrast agents having different sizes is used such that frequencies of ultrasonic waves emitted from the plurality of photoacoustic/ultrasound contrast agents are different, and
the detection imaging device obtains a plurality of photoacoustic images by individually detecting and imaging the different frequencies of the ultrasonic waves.

13 . The diagnosis system of claim 12 , wherein the detection imaging device includes a plurality of ultrasound transducers detecting the ultrasonic waves emitted from the plurality of photoacoustic/ultrasound contrast agents, and
each of the plurality of ultrasound transducers has a frequency band containing the frequency of the ultrasonic wave emitted from the associated contrast agent.

14 . The diagnosis system of claim 12 , wherein as the ultrasound transducer, one wideband ultrasound transducer having all frequency bands of the ultrasonic waves emitted from the plurality of photoacoustic/ultrasound contrast agents is used, or an integrated ultrasound transducer having different frequency bands is used.

15 . The diagnosis system of claim 9 , wherein the photoacoustic/ultrasound contrast agent includes micro-bubbles having gas inside thereof and a photoacoustic contrast component that is conjugated to a surface of the micro-bubbles or is stacked inside thereof.

16 . The diagnosis system of claim 15 , wherein the photoacoustic/ultrasound contrast agent includes a ligand that is conjugated to the surface of the micro-bubbles and targets a particular biomarker,
the gas is at least one of perfluorocarbon and sulfur hexafluoride, the micro-bubbles are made of protein or lipid, and the photoacoustic contrast component is at least one of porphyrin, indocyanine green, green fluorescence protein (GFP), ferritin, and gold nanorod.

17 . The diagnosis system of claim 15 , wherein the frequency of the ultrasonic wave emitted from the photoacoustic/ultrasound contrast agent is a resonant frequency that occurs when the ultrasonic wave emitted from the photoacoustic contrast component is resonated by the micro-bubble.

18 . The diagnosis system of claim 10 , wherein the photoacoustic/ultrasound contrast agent includes micro-bubbles having gas inside thereof and a photoacoustic contrast component that is conjugated to a surface of the micro-bubbles or is stacked inside thereof.

19 . The diagnosis system of claim 11 , wherein the photoacoustic/ultrasound contrast agent includes micro-bubbles having gas inside thereof and a photoacoustic contrast component that is conjugated to a surface of the micro-bubbles or is stacked inside thereof.

20 . The diagnosis system of claim 12 , wherein the photoacoustic/ultrasound contrast agent includes micro-bubbles having gas inside thereof and a photoacoustic contrast component that is conjugated to a surface of the micro-bubbles or is stacked inside thereof.

Assignees

• Univ Sogang Res Foundation

Inventors

• Kim Hyuncheol
• Chang Jin Ho
• Moon Hyung Won
• Lee Ho Hyun

Classifications

• A61K49/223

  Microbubbles, hollow microspheres, free gas bubbles, gas microspheres · CPC title

• A61B5/0095

  by applying light and detecting acoustic waves, i.e. photoacoustic measurements · CPC title

• A61B8/4416 Primary

  related to combined acquisition of different diagnostic modalities, e.g. combination of ultrasound and X-ray acquisitions · CPC title

• A61B8/481

  involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream · CPC title

• A61B8/4477

  using several separate ultrasound transducers or probes · CPC title